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Summary
Your body's immune system protects you from disease and infection. But if you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake. Autoimmune diseases can affect many parts of the body.
No one is sure what causes autoimmune diseases. They do tend to run in families. Women - particularly African American, Hispanic American, and Native American women - have a higher risk for some autoimmune diseases.
There are more than 80 types of autoimmune diseases, and some have similar symptoms. This makes it hard for your health care provider to know if you really have one of these diseases, and if so, which one. Getting a diagnosis can be frustrating and stressful. Often, the first symptoms are fatigue, muscle aches and a low fever. The classic sign of an autoimmune disease is inflammation, which can cause redness, heat, pain and swelling.
The diseases may also have flare-ups, when they get worse, and remissions, when symptoms get better or disappear. Treatment depends on the disease, but in most cases one important goal is to reduce inflammation. Sometimes doctors prescribe corticosteroids or other drugs that reduce your immune response.
Diagnosis and Tests
-
ANA (Antinuclear Antibody) Test
(National Library of Medicine) Also in Spanish
- Autoantibodies (American Association for Clinical Chemistry)
- Blood Test: Immunoglobulin A (IgA) (Nemours Foundation) Also in Spanish
-
C-Reactive Protein (CRP) Test
(National Library of Medicine) Also in Spanish
-
Complement Blood Test
(National Library of Medicine) Also in Spanish
-
Erythrocyte Sedimentation Rate (ESR)
(National Library of Medicine) Also in Spanish
-
Immunofixation (IFE) Blood Test
(National Library of Medicine) Also in Spanish
-
Immunoglobulins Blood Test
(National Library of Medicine) Also in Spanish
-
Pharmacogenetic Tests
(National Library of Medicine) Also in Spanish
Related Issues
- Associated Autoimmune Diseases (Gluten Intolerance Group)
Specifics
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Anti-GBM (Goodpasture's) Disease
(National Institute of Diabetes and Digestive and Kidney Diseases)
-
Autoimmune Hepatitis
(National Institute of Diabetes and Digestive and Kidney Diseases) Also in Spanish
-
Autoimmune Lymphoproliferative Syndrome (ALPS)
(National Institute of Allergy and Infectious Diseases)
-
Autoinflammatory Diseases
(National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- Familial Mediterranean Fever (Mayo Foundation for Medical Education and Research) Also in Spanish
-
Lambert-Eaton Myasthenic Syndrome
(National Institute of Neurological Disorders and Stroke)
-
Learning about Antiphospholipid Syndrome (APS)
(National Human Genome Research Institute)
-
Neuromyelitis Optica
(National Institute of Neurological Disorders and Stroke) Also in Spanish
-
Paraneoplastic Syndromes
(National Institute of Neurological Disorders and Stroke)
-
Primary Biliary Cholangitis (Primary Biliary Cirrhosis)
(National Institute of Diabetes and Digestive and Kidney Diseases)
-
Stiff-Person Syndrome
(National Institute of Neurological Disorders and Stroke)
-
What Is Antiphospholipid Antibody Syndrome?
(National Heart, Lung, and Blood Institute)
Genetics
-
autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: MedlinePlus Genetics
(National Library of Medicine)
-
immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: MedlinePlus Genetics
(National Library of Medicine)
-
otulipenia: MedlinePlus Genetics
(National Library of Medicine)
-
STING-associated vasculopathy with onset in infancy: MedlinePlus Genetics
(National Library of Medicine)
Statistics and Research
-
Inflammation
(National Institute of Environmental Health Sciences)
-
Shaking Out Clues to Autoimmune Disease
(National Institute of Arthritis and Musculoskeletal and Skin Diseases)
-
Study Provides Insights into Diagnosis, Treatment of Rare Immune Disease: Autoimmmune Lymphoproliferative Syndrome (ALPS)
(National Institute of Allergy and Infectious Diseases)
Clinical Trials
-
ClinicalTrials.gov: Autoimmune Diseases
(National Institutes of Health)
-
ClinicalTrials.gov: Hereditary Autoinflammatory Diseases
(National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
Reference Desk
-
Overview of the Immune System
(National Institute of Allergy and Infectious Diseases)
Children
- What Is a Pediatric Rheumatologist? (American Academy of Pediatrics) Also in Spanish
Teenagers
- Immune System (Nemours Foundation) Also in Spanish
Women
- Pregnancy and Rheumatic Disease (American College of Rheumatology) Also in Spanish
Patient Handouts
- Autoimmune disorders (Medical Encyclopedia) Also in Spanish
- Complement (Medical Encyclopedia) Also in Spanish