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Summary
Guillain-Barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (PNS). The PNS nerves connect your brain and spinal cord with the rest of your body. Damage to these nerves makes it hard for them to transmit signals. As a result, your muscles have trouble responding to your brain. No one knows what causes the syndrome. Sometimes it is triggered by an infection, surgery, or a vaccination.
The first symptom is usually weakness or a tingling feeling in your legs. The feeling can spread to your upper body. In severe cases, you become almost paralyzed. This is life-threatening. You might need a respirator to breathe. Symptoms usually worsen over a period of weeks and then stabilize.
Guillain-Barre can be hard to diagnose. Possible tests include nerve tests and a spinal tap. Most people recover. Recovery can take a few weeks to a few years. Treatment can help symptoms, and may include medicines or a procedure called plasma exchange.
NIH: National Institute of Neurological Disorders and Stroke
- Guillain-Barre Syndrome (Mayo Foundation for Medical Education and Research) Also in Spanish
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Guillain-Barré Syndrome
(National Institute of Neurological Disorders and Stroke)
Diagnosis and Tests
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Cerebrospinal Fluid (CSF) Analysis
(National Library of Medicine)
Also in Spanish
Related Issues
Specifics
- Miller Fisher Syndrome (GBS/CIDP Foundation International)
Genetics
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Guillain-Barré syndrome: MedlinePlus Genetics
(National Library of Medicine)
Clinical Trials
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ClinicalTrials.gov: Guillain-Barre Syndrome
(National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Clinico-epidemiological profile and prediction of outcome in children with Guillain-Barre syndrome.
- Article: Risk of Guillain-Barré syndrome after COVID-19 vaccination or SARS-CoV-2 infection: A...
- Article: Assessment of Hemodynamic Changes During Large-Volume Plasmapheresis with a Non-Invasive Cardiac...
- Guillain-Barre Syndrome -- see more articles
Children
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Children with GBS
(GBS/CIDP Foundation International)
Patient Handouts
- Cerebral spinal fluid (CSF) collection (Medical Encyclopedia) Also in Spanish
- Chronic inflammatory demyelinating polyneuropathy (Medical Encyclopedia) Also in Spanish
- Guillain-Barre syndrome (Medical Encyclopedia) Also in Spanish