Myasthenia gravis is a disease that causes weakness in your voluntary muscles. These are the muscles that you control. For example, you may have weakness in the muscles for eye movement, facial expressions, and swallowing. You can also have weakness in other muscles. This weakness gets worse with activity, and better with rest.
Myasthenia gravis is an autoimmune disease. Your body's immune system makes antibodies that block or change some of the nerve signals to your muscles. This makes your muscles weaker.
Other conditions can cause muscle weakness, so myasthenia gravis can be hard to diagnose. Tests used to make a diagnosis include blood, nerve, muscle, and imaging tests.
With treatment, the muscle weakness often gets much better. Medicines can help improve nerve-to-muscle messages and make muscles stronger. Other drugs keep your body from making so many abnormal antibodies. These medicines can have major side effects, so they should be used carefully. There are also treatments which filter abnormal antibodies from the blood or add healthy antibodies from donated blood. Sometimes, surgery to take out the thymus gland helps.
Some people with myasthenia gravis go into remission. This means that they do not have symptoms. The remission is usually temporary, but sometimes it can be permanent.
NIH: National Institute of Neurological Disorders and Stroke
- Myasthenia Gravis (Mayo Foundation for Medical Education and Research) Also in Spanish
- Myasthenia Gravis (National Institute of Neurological Disorders and Stroke) - Short Summary
- Myasthenia Gravis Fact Sheet (Department of Health and Human Services, Office on Women's Health) Also in Spanish
- Myasthenia Gravis, Lambert-Eaton Myasthenic Syndrome & Congenital Myasthenic Syndromes (Muscular Dystrophy Association) - PDF Also in Spanish
Treatments and Therapies
- Myasthenia Gravis (MG): Medical Management (Muscular Dystrophy Association)
- Thymectomy: Common Questions Patients Ask about Thymectomies (Myasthenia Gravis Foundation of America) - PDF
- Treatment for Myasthenia Gravis (MG) (Myasthenia Gravis Foundation of America)
- Dental Treatment Considerations (Myasthenia Gravis Foundation of America) - PDF
- Emergency Management of Myasthenia Gravis (Myasthenia Gravis Foundation of America) - PDF
- Home Injury Prevention (Myasthenia Gravis Foundation of America) - PDF
- Nutrition and Myasthenia Gravis (Myasthenia Gravis Foundation of America) - PDF
- Employees with Myasthenia Gravis (Office of Disability Employment Policy)
- Myasthenia Gravis Complications (Mayo Foundation for Medical Education and Research)
- Myasthenia Gravis Medication Information Card (Drugs to be Avoided or Used with Caution in Myasthenia Gravis) (Myasthenia Gravis Foundation of America) - PDF
- Myasthenia Gravis: Drugs to be Avoided (Myasthenia Gravis Foundation of America)
- Genetics Home Reference: myasthenia gravis (National Library of Medicine)
- ClinicalTrials.gov: Myasthenia Gravis (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan.
- Article: Subcutaneous immunoglobulin in myasthenia gravis exacerbation: A prospective, open-label trial.
- Article: Rituximab as treatment for anti-MuSK myasthenia gravis: Multicenter blinded prospective...
- Myasthenia Gravis -- see more articles
- Things to Consider If You Have MG and Are Thinking about Getting Pregnant (Myasthenia Gravis Foundation of America) - PDF