Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.
A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.
- Weight loss
- Muscle weakness
- Fatigue that gets worse over time
- Low blood pressure
- Patchy or dark skin
Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
- Autoimmune Addison disease: MedlinePlus Genetics (National Library of Medicine)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: 21-Hydroxylase-Specific CD8+ T Cells in Autoimmune Addison's Disease Are Restricted by...
- Article: The natural history of 21-hydroxylase autoantibodies in autoimmune Addison's disease.
- Article: Vitamin D status and its associations with clinical and laboratory parameters...
- Addison Disease -- see more articles