See, Play and Learn
Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or "ugly looking."
Thinking of "ABCDE" can help you remember what to watch for:
- Asymmetry - the shape of one half does not match the other
- Border - the edges are ragged, blurred or irregular
- Color - the color is uneven and may include shades of black, brown and tan
- Diameter - there is a change in size, usually an increase
- Evolving - the mole has changed over the past few weeks or months
Surgery is the first treatment of all stages of melanoma. Other treatments include chemotherapy and radiation, biologic, and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells.
NIH: National Cancer Institute
Diagnosis and Tests
- BRAF Genetic Test (National Library of Medicine) Also in Spanish
- Lymphoscintigraphy (American College of Radiology; Radiological Society of North America) Also in Spanish
- PDL1 (Immunotherapy) Tests (National Library of Medicine) Also in Spanish
- Sentinel Lymph Node Biopsy (National Library of Medicine) Also in Spanish
- Skin Biopsy (VisualDX)
- Skin Cancer Screening (National Library of Medicine) Also in Spanish
- Skin Cancer Screening (National Cancer Institute) Also in Spanish
- Stages of Melanoma (National Cancer Institute) Also in Spanish
- Tests for Melanoma Skin Cancer (American Cancer Society) Also in Spanish
- General Information about Intraocular (Uveal) Melanoma (National Cancer Institute) Also in Spanish
- Ocular Melanoma (American Academy of Ophthalmology) Also in Spanish
- Giant congenital melanocytic nevus: MedlinePlus Genetics (National Library of Medicine)
- Melanoma: MedlinePlus Genetics (National Library of Medicine)
Statistics and Research
- Advances in Melanoma and Other Skin Cancers Research (National Cancer Institute)
- Cancer Stat Facts: Melanoma of the Skin (National Cancer Institute)
- Melanoma of the Skin Statistics (Centers for Disease Control and Prevention)
- Some Melanomas May Start in Hair Follicles (National Institutes of Health)
- What's New in Research and Treatment of Melanoma Skin Cancer? (American Cancer Society) Also in Spanish
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: First-in-human phase I/Ib study of NIZ985, a recombinant heterodimer of IL-15...
- Article: Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the...
- Article: Comparison of humans versus mobile phone-powered artificial intelligence for the diagnosis...
- Melanoma -- see more articles