Bone Marrow Diseases

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Basics

• Summary
• Diagnosis and Tests
• Treatments and Therapies

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• Specifics
• Genetics

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Summary

Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting.

With bone marrow disease, there are problems with the stem cells or how they develop:

• In leukemia, a cancer of the blood, the bone marrow makes abnormal white blood cells
• In aplastic anemia, the bone marrow doesn't make red blood cells
• In myeloproliferative disorders, the bone marrow makes too many white blood cells
• Other diseases, such as lymphoma, can spread into the bone marrow and affect the production of blood cells

Causes of bone marrow diseases include genetics and environmental factors. Tests for bone marrow diseases include blood and bone marrow tests. Treatments depend on the disorder and how severe it is. They might involve medicines, blood transfusions or a bone marrow transplant.

Diagnosis and Tests

• Blood Count Tests: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish
• Bone Marrow Test (National Library of Medicine) Also in Spanish
• Reticulocyte Count Also in Spanish
• What Are Bone Marrow Tests? (National Heart, Lung, and Blood Institute)

Treatments and Therapies

• Bone Marrow Transplantation: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish
• Drugs Approved for Myeloproliferative Neoplasms (National Cancer Institute)
• Myelodysplastic/ Myeloproliferative Neoplasms Treatment (National Cancer Institute) Also in Spanish
• Treatment Option Overview (Chronic Myeloproliferative Neoplasms) (National Cancer Institute) Also in Spanish
• Treatment Option Overview (Myelodysplastic/Myeloproliferative Neoplasms) (National Cancer Institute) Also in Spanish
• Treatment Options for Chronic Myeloproliferative Neoplasms (National Cancer Institute) Also in Spanish
• Treatment Options for Myelodysplastic/Myeloproliferative Neoplasms (National Cancer Institute) Also in Spanish

Specifics

• Atypical Chronic Myelogenous Leukemia (National Cancer Institute) Also in Spanish
• Essential Thrombocythemia (National Cancer Institute) Also in Spanish
• Fanconi Anemia (National Heart, Lung, and Blood Institute)
• General Information about Chronic Myeloproliferative Neoplasms (National Cancer Institute) Also in Spanish
• General Information about Myelodysplastic/Myeloproliferative Neoplasms (National Cancer Institute) Also in Spanish
• Juvenile Myelomonocytic Leukemia (National Cancer Institute) Also in Spanish
• Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable (National Cancer Institute) Also in Spanish
• Myelofibrosis (Mayo Foundation for Medical Education and Research)
• Polycythemia Vera (National Heart, Lung, and Blood Institute)
• Primary Myelofibrosis (National Cancer Institute) Also in Spanish
• Thrombocythemia and Thrombocytosis (National Heart, Lung, and Blood Institute)

Genetics

• 8p11 myeloproliferative syndrome: MedlinePlus Genetics (National Library of Medicine)
• ataxia-pancytopenia syndrome: MedlinePlus Genetics (National Library of Medicine)
• Diamond-Blackfan anemia: MedlinePlus Genetics (National Library of Medicine)
• essential thrombocythemia: MedlinePlus Genetics (National Library of Medicine)
• Fanconi anemia: MedlinePlus Genetics (National Library of Medicine)
• paroxysmal nocturnal hemoglobinuria: MedlinePlus Genetics (National Library of Medicine)
• Pearson marrow-pancreas syndrome: MedlinePlus Genetics (National Library of Medicine)
• polycythemia vera: MedlinePlus Genetics (National Library of Medicine)
• primary myelofibrosis: MedlinePlus Genetics (National Library of Medicine)
• Shwachman-Diamond syndrome: MedlinePlus Genetics (National Library of Medicine)

Clinical Trials

• ClinicalTrials.gov: Bone Marrow Diseases (National Institutes of Health)
• ClinicalTrials.gov: Myeloproliferative Disorders (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

• Article: Fedratinib hydrochloride to treat intermediate-2 or high-risk primary or secondary myelofibrosis.
• Article: A study of 18F-FLT positron emission tomography/computed tomography imaging in cases...
• Article: The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem...
• Bone Marrow Diseases -- see more articles

Find an Expert

• American Cancer Society
• Leukemia & Lymphoma Society
• National Cancer Institute Also in Spanish
• National Heart, Lung, and Blood Institute

Patient Handouts

• Bone marrow aspiration (Medical Encyclopedia) Also in Spanish
• Bone marrow culture (Medical Encyclopedia) Also in Spanish
• Bone marrow transplant (Medical Encyclopedia) Also in Spanish
• Bone marrow transplant - discharge (Medical Encyclopedia) Also in Spanish
• Myelofibrosis (Medical Encyclopedia) Also in Spanish
• Polycythemia vera (Medical Encyclopedia) Also in Spanish