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Summary
Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into red blood cells, which carry oxygen throughout the body, white blood cells, which fight infections, and platelets, which help the blood to clot.
A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. Doctors use these transplants to treat people with certain diseases, such as:
- Leukemia
- Severe blood diseases such as thalassemias, aplastic anemia, and sickle cell anemia
- Multiple myeloma
- Certain immune deficiency diseases
Before you have a transplant, you need to get high doses of chemotherapy and possibly radiation. This destroys the faulty stem cells in your bone marrow. It also suppresses your body's immune system so that it won't attack the new stem cells after the transplant.
In some cases, you can donate your own bone marrow stem cells in advance. The cells are saved and then used later on. Or you can get cells from a donor. The donor might be a family member or unrelated person.
Bone marrow transplantation has serious risks. Some complications can be life-threatening. But for some people, it is the best hope for a cure or a longer life.
NIH: National Heart, Lung, and Blood Institute
Living With
Related Issues
- Need for More Marrow Donors (Health Resources and Services Administration)
- Planning for a Transplant -- Blood Stem Cell (Health Resources and Services Administration)
- Stem Cell or Bone Marrow Transplant Side Effects (American Cancer Society) Also in Spanish
- Treatment Steps Before a Blood Stem Cell Transplant (NMDP)
- What Is Graft-Versus-Host Disease (GVHD)? (NMDP)
- What Is It Like to Donate Stem Cells or Bone Marrow? (American Cancer Society) Also in Spanish
Specifics
- Bone Marrow and Blood Stem Cell Donor FAQs (NMDP) Also in Spanish
Images
- Bone-marrow transplant - series (Medical Encyclopedia) Also in Spanish
Videos and Tutorials
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Becoming a Blood Stem Cell Donor
(National Cancer Institute)
Statistics and Research
- Donation and Transplantation Statistics (Health Resources and Services Administration)
Clinical Trials
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ClinicalTrials.gov: Bone Marrow Transplantation
(National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Intraosseous Bone Marrow Concentrate and Long-Term Procedure-Free Survival in Bilateral Non-Traumatic...
- Article: Idiopathic Pneumonia Syndrome and Pulmonary Toxicity After Total Body Irradiation for...
- Article: Combined Subchondral, Intradiscal and Peridiscal BMAC Injections for Advanced Degenerative Discs...
- Bone Marrow Transplantation -- see more articles
Find an Expert
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National Cancer Institute
Also in Spanish
- U.S. Transplant Center Directory (NMDP)
Patient Handouts
- Bone marrow (stem cell) donation (Medical Encyclopedia) Also in Spanish
- Bone marrow transplant (Medical Encyclopedia) Also in Spanish
- Bone marrow transplant - discharge (Medical Encyclopedia) Also in Spanish
- Bone marrow transplant in children - discharge (Medical Encyclopedia) Also in Spanish