Amyloidosis occurs when abnormal proteins called amyloids build up and form deposits. The deposits can collect in organs such as the kidney and heart. This can cause the organs to become stiff and unable to work the way they should.
There are three main types of amyloidosis:
- Primary - with no known cause
- Secondary - caused by another disease, including some types of cancer
- Familial - passed down through genes
Symptoms can vary, depending upon which organs are affected. Treatment depends on the type of amyloidosis you have. The goal is to help with symptoms and limit the production of proteins. If another disease is the cause, it needs to be treated.
- AL Amyloidosis and Agent Orange (Department of Veterans Affairs)
- General Information about Plasma Cell Neoplasms (Including Multiple Myeloma) (National Cancer Institute) Also in Spanish
- Cardiac Amyloidosis (American Heart Association)
- Hereditary cerebral amyloid angiopathy: MedlinePlus Genetics (National Library of Medicine)
- Lattice corneal dystrophy type II: MedlinePlus Genetics (National Library of Medicine)
- Primary localized cutaneous amyloidosis: MedlinePlus Genetics (National Library of Medicine)
- Transthyretin amyloidosis: MedlinePlus Genetics (National Library of Medicine)
- ClinicalTrials.gov: Amyloidosis (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions...
- Article: Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis - 2021.
- Article: Significance of Oligomeric and Fibrillar Species in Amyloidosis: Insights into Pathophysiology...
- Amyloidosis -- see more articles