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Summary
What are antibiotics?
Antibiotics are medicines that treat bacterial infections in humans and animals. They work by killing the bacteria or making it hard for the bacteria to grow and multiply. When used properly, antibiotics can save lives. But there is a growing problem of antibiotic resistance.
What is antibiotic resistance?
Antibiotic resistance happens when bacteria change and can resist the effects of an antibiotic. The bacteria are not killed, and they continue to grow. The infections these bacteria cause are called resistant infections. Resistant infections can be difficult, and sometimes impossible, to treat. In some cases, they can even be deadly.
Antibiotic resistance does not mean that your body is resistant to antibiotics.
There are many different types of resistant infections. They include MRSA and drug-resistant tuberculosis (TB). If you get a resistant infection, you might need:
- A long hospital stay
- A long recovery
- Follow-up visits with health care providers
- Treatments that are expensive and may have severe side effects
Antibiotic resistance is one type of antimicrobial resistance. There are other types; viruses, fungi, and parasites can also become resistant to medicines.
How do bacteria become resistant to antibiotics?
Antibiotic resistance is a natural process that happens over time. To survive, bacteria can develop defense strategies against antibiotics. This happens through genetic changes in the bacteria. These resistant bacteria survive, grow, and spread.
Each time you take antibiotics, there is a risk that the bacteria will become resistant. So it is important to only take antibiotics when you really need them. They won't work on viral infections such as colds and the flu. And you don't need antibiotics for every bacterial infection. For example, you may not need them for some sinus and ear infections.
Who is more likely to develop an antibiotic-resistant infection?
Anyone can develop an antibiotic-resistant infection, but certain people may be at higher risk, including those who:
- Have a weakened immune system from diseases such as HIV or from taking medicines that affect the immune system
- Are getting medical care such as surgery and hospital stays
- Take antibiotics for a long time
- Are infants, especially if they were born prematurely
- Are older adults
How can antibiotic resistance be prevented?
There will always be some antibiotic resistance, since it happens naturally. But you can help fight against antibiotic resistance by taking these steps:
- Don't use antibiotics for viruses.
- Don't pressure your health care provider to give you an antibiotic if they don't think you need one.
- When you take antibiotics, follow the directions carefully.
- Don't share your antibiotics with others.
- Don't save antibiotics for later or use someone else's prescription.
- Help prevent the spread of bacterial infections with good hygiene habits. These include washing your hands often and covering your mouth and nose when coughing or sneezing.
Centers for Disease Control and Prevention
Diagnosis and Tests
- Antibiotic Sensitivity Test (National Library of Medicine) Also in Spanish
Prevention and Risk Factors
- Antibiotics and Antibiotic Resistance (Food and Drug Administration)
- Antimicrobial Resistance: Causes and How It Spreads (Centers for Disease Control and Prevention)
- Controlling the Emergence and Spread of Antimicrobial Resistance (Centers for Disease Control and Prevention)
Treatments and Therapies
- Combating Antibiotic Resistance (Food and Drug Administration)
- What Can Be Done about Antibiotic Resistance? (Alliance for the Prudent Use of Antibiotics)
Specifics
- About Carbapenem-resistant Enterobacterales (Centers for Disease Control and Prevention)
- Antimicrobial Resistance (World Health Organization) Also in Spanish
- Antimicrobial Resistance Threats (National Institute of Allergy and Infectious Diseases)
- Antimicrobial Resistance, Food, and Food Animals (Centers for Disease Control and Prevention)
- Drug-Resistant Gonorrhea (Centers for Disease Control and Prevention)
- Vancomycin-resistant Enterococci (VRE) Basics (Centers for Disease Control and Prevention)
Images
- How Antibiotic Resistance Happens (Centers for Disease Control and Prevention) - PDF
- How Antibiotic Resistance Spreads (Centers for Disease Control and Prevention) - PDF
Videos and Tutorials
- Animation of Antimicrobial Resistance (Food and Drug Administration)
- Antibiotics vs. Bacteria: Fighting the Resistance (National Library of Medicine) Also in Spanish
Statistics and Research
- 2019 Antibiotic Resistance Threats Report (Centers for Disease Control and Prevention)
- Stamping Out Superbugs (National Institutes of Health) Also in Spanish
- What Is Antibiotic Resistance? (National Institute of General Medical Sciences)
Clinical Trials
- ClinicalTrials.gov: Antibiotic Resistance (National Institutes of Health)
- ClinicalTrials.gov: Vancomycin-Resistant Enterococci (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Prophage-encoded antibiotic resistance genes are enriched in human-impacted environments.
- Article: Using priorities between human and livestock bacterial antimicrobial resistance (AMR) to...
- Article: Relationship Between Fluoroquinolone Resistance and Mutations in the Quinolone Resistance-Determining Region...
- Antibiotic Resistance -- see more articles
Reference Desk
- Glossary (Antibiotics) (Alliance for the Prudent Use of Antibiotics)
Children
- Danger of Antibiotic Overuse (For Parents) (Nemours Foundation) Also in Spanish
Patient Handouts
- Vancomycin-resistant enterococci - hospital (Medical Encyclopedia) Also in Spanish