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Summary
What is Sjogren's syndrome?
Sjogren's syndrome, also called Sjogren's disease, is a chronic (long-lasting) autoimmune disease. When you have an autoimmune disease, your immune system attacks healthy tissues and organs by mistake. In Sjogren's syndrome, your immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body. This causes a dry mouth and dry eyes. You may have dryness in other places that need moisture, such as your nose, throat, and skin. Sjogren's can also affect other parts of the body, including your joints, lungs, kidneys, blood vessels, digestive organs, and nerves.
What causes Sjogren's syndrome?
Normally, your immune system protects the body from infection and disease. But with Sjogren's syndrome and other autoimmune diseases, your immune system attacks healthy tissues and organs. Researchers don't know for sure what causes the immune system to do this. But they think that it is caused by a combination of genetic and environmental factors. Studies have linked Sjogren's syndrome to gene changes in several genes. Some researchers also think that the disease may be triggered by something in the environment. For example, they think that one possible trigger could be a previous infection with a virus or bacteria.
Who is more likely to develop Sjogren's syndrome?
Most people with Sjogren's syndrome are women. You can get it at any age, but it is most common in people in their 40s and 50s.
Sjogren's syndrome is more common in people who have other autoimmune diseases such as rheumatoid arthritis and lupus. This is known as a secondary form of Sjogren's syndrome. People who don't have another autoimmune disease have a primary form of Sjogren's syndrome.
What are the symptoms of Sjogren's syndrome?
Sjogren's syndrome may have different effects on the body. Not everyone will have the same symptoms. Some people have cycles of mild and then severe symptoms.
The two main symptoms are:
- Dry eyes. Your eyes may burn or itch or feel like they have sand in them. Sometimes your vision may be blurry, or you could be bothered by bright lights.
- Dry mouth. Your tongue and your throat may feel dry. You might have trouble swallowing, speaking, and tasting.
Sjogren's syndrome can also affect other parts of the body, causing symptoms such as:
- Joint and muscle pain
- Dry skin
- Rashes on the skin of hands or feet
- Numbness or tingling in the hands or feet
- Vaginal dryness
- Dry cough that doesn't go away
- Fatigue that doesn't go away
How is Sjogren's syndrome diagnosed?
There is no single test for Sjogren's syndrome. To find out if you have it, your provider:
- Will ask about your medical history and symptoms.
- Will do a physical exam, which includes checking for signs of dry mouth and signs of related autoimmune diseases.
- May order tests, including:
- Eye tests to see if you produce a normal amount of tears and to find out if your eyes have been damaged by dryness.
- Salivary gland tests to measure how much saliva your mouth produces. They could include imaging tests and a biopsy.
- Blood tests.
What are the treatments for Sjogren's syndrome?
There is no cure for Sjogren's syndrome. Treatment focuses on relieving your symptoms. The treatments can be different for each person, depending on which parts of the body are affected. They may include:
- Eye drops (artificial tears) or ointments to relieve dryness in the eyes.
- Saliva substitutes.
- Prescription medicines that cause your salivary glands to make more saliva.
- A minor procedure that places small plugs the tear duct in the corners of the eyes. The plugs block your tears from draining so they stay in your eyes longer.
- Medicines to help with other symptoms caused by Sjogren's syndrome, such as medicines for pain and inflammation.
- Medicines that suppress (weaken) your immune system (for severe cases).
You can also try to relieve some of your symptoms by sucking on sugar-free candy, drinking water often, increasing the humidity in your room, and not smoking. Because having a dry mouth can raise your risk of cavities, it's important to take good care of your teeth and see your dentist regularly.
Diagnosis and Tests
- ANA (Antinuclear Antibody) Test (National Library of Medicine) Also in Spanish
- Rheumatoid Factor (RF) Test (National Library of Medicine) Also in Spanish
Treatments and Therapies
- Simple Solutions for Dry Eye (Sjogren's Syndrome Foundation) - PDF
Living With
- Tips for Chronic Pain (Sjogren's Syndrome Foundation) - PDF
- Tips on Sleep for Sjogren's Patients (Sjogren's Syndrome Foundation) - PDF
Related Issues
- Sun and Sjogren's Syndrome (Sjogren's Syndrome Foundation) - PDF
- Surgery, Hospitals, and Medications (Sjogren's Syndrome Foundation) - PDF
- Tips for Airline Travelers with Sjogren's Syndrome (Sjogren's Syndrome Foundation) - PDF
Specifics
- Dry Eye (National Eye Institute) Also in Spanish
- Dry Mouth (National Institute of Dental and Craniofacial Research) Also in Spanish
- Dry Mouth: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish
- Dry Skin (Sjogren's Syndrome Foundation) - PDF
- What Is Dry Eye? (American Academy of Ophthalmology) Also in Spanish
Genetics
- Sjögren syndrome: MedlinePlus Genetics (National Library of Medicine)
Clinical Trials
- ClinicalTrials.gov: Sjogren's Syndrome (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Predicting thyroid involvement in primary Sjögren's syndrome: development and validation of...
- Article: Sjögren's Disease and Gastroesophageal Reflux Disease: What Is Their Evidence-Based Link?
- Article: Evaluation of the Hypothalamic-Pituitary-Adrenal Axis in Patients with Primary Sjögren's Disease.
- Sjogren's Syndrome -- see more articles
Find an Expert
- Find a Rheumatologist (American College of Rheumatology)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish
- National Institute of Dental and Craniofacial Research Also in Spanish
- National Institute of Neurological Disorders and Stroke Also in Spanish
- Sjogren's Syndrome Foundation
Children
- Sjögren's in Children (Sjogren's Syndrome Foundation)
Women
- Sjӧgren's and Pregnancy (Arthritis Foundation)
Patient Handouts
- Rheumatoid factor (RF) (Medical Encyclopedia) Also in Spanish
- Sjogren syndrome (Medical Encyclopedia) Also in Spanish