Colitis is swelling (inflammation) of the large intestine (colon).
Most of the times, the cause of colitis is not known.
Causes of colitis include:
- Infections caused by a virus or a parasite
- Food poisoning due to bacteria
- Crohn disease
- Ulcerative colitis
- Lack of blood flow (ischemic colitis)
- Past radiation to the large bowel (radiation colitis and strictures)
- Necrotizing enterocolitis in newborns
- Pseudomembranous colitis caused by Clostridium difficile infection
Exams and Tests
The health care provider will perform a physical exam. You will also be asked questions about your symptoms, such as:
- How long have you had the symptoms?
- How severe is your pain?
- How often do you have pain and how long does it last?
- How often do you have diarrhea?
- Have you been traveling?
- Have you been taking antibiotics recently?
Your provider may recommend a flexible sigmoidoscopy or colonoscopy. During this test, a flexible tube is inserted through the rectum to examine the colon. You may have biopsies taken during this exam. Biopsies may show changes related to inflammation. This can help determine the cause of colitis.
Other studies that can identify colitis include:
Your treatment will depend on the cause of the disease.
The outlook depends on the cause of the problem.
- Crohn disease is a chronic condition which has no cure but can be controlled.
- Ulcerative colitis can usually be controlled with medicines. If not controlled, it can be cured by surgically removing the colon.
- Viral, bacterial and parasitic colitis can be cured with appropriate medicines.
- Pseudomembraneous colitis can usually be cured with appropriate antibiotics.
Complications may include:
- Bleeding with bowel movements
- Perforation of the colon
- Toxic megacolon
- Sore (ulceration)
When to Contact a Medical Professional
Call your provider if you have symptoms such as:
- Abdominal pain that does not get better
- Blood in the stool or stools that look black
- Diarrhea or vomiting that does not go away
- Swollen abdomen
Lichtenstein GR. Inflammatory bowel disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 132.
Osterman MT, Lichtenstein GR. Ulcerative colitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 116.
Wald A. Other diseases of the colon and rectum. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 10th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 128.
Review Date 7/11/2019
Updated by: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.