Toxic megacolon occurs when swelling and inflammation spread into the deeper layers of your colon. As a result, the colon stops working and widens. In severe cases, the colon may rupture.
The term "toxic" means that this problem is very dangerous. Toxic megacolon may occur in people with an inflamed colon due to:
Other forms of megacolon include pseudo-obstruction, acute colonic ileus, or congenital colonic dilation. These conditions do not involve an infected or inflamed colon.
Treatment of the disorder that led to toxic megacolon may be started, including:
- Steroids and other medicines that suppress the immune system
If you have septic shock, you will be admitted to the intensive care unit of the hospital. Treatment may include:
- Breathing machine (mechanical ventilation)
- Dialysis for kidney failure
- Drugs to treat low blood pressure, infection, or poor blood clotting
- Fluids given directly into a vein (intravenously)
If rapid widening is allowed to continue, an opening or rupture can form in the colon. Therefore, most cases of toxic megacolon will need surgery to remove a part of or the entire colon.
You may receive antibiotics to prevent sepsis (a severe infection).
If the condition does not improve, it can be life threatening. In this case, a colectomy is usually needed.
Complications may include:
- Perforation of the colon
When to Contact a Medical Professional
Go to the emergency room or call the local emergency number (such as 911) if you develop severe abdominal pain, especially if you also have:
- Bloody diarrhea
- Frequent diarrhea
- Rapid heart rate
- Tenderness when the abdomen is pressed
Treating diseases that cause toxic megacolon, such as ulcerative colitis or Crohn disease, can prevent this condition.
Toxic dilation of the colon; Megarectum; Inflammatory bowel disease - toxic megacolon; Crohn disease - toxic megacolon; Ulcerative colitis - toxic megacolon
Lichtenstein GR. Inflammatory bowel disease. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 141.
Marrero F. Severe complications of inflammatory bowel disease. Med Clin North Am. 2008;92:671-686. PMID: 18387381 www.ncbi.nlm.nih.gov/pubmed/18387381.
Peterson MA. Disorders of the large intestine. In: Marx JA, Hockberger RS, Walls RM, et al, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 95.
Review Date 10/27/2015
Updated by: Subodh K. Lal, MD, gastroenterologist with Gastrointestinal Specialists of Georgia, Austell, GA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.