Ankylosing spondylitis is a type of arthritis of the spine. It causes inflammation between your vertebrae, which are the bones that make up your spine, and in the joints between your spine and pelvis. In some people, it can affect other joints.
AS is more common and more severe in men. It often runs in families. The cause is unknown, but it is likely that both genes and factors in the environment play a role.
Early symptoms of AS include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, AS can fuse your vertebrae together, limiting movement. Some people have symptoms that come and go. Others have severe, ongoing pain.
A diagnosis of AS is based on your medical history and a physical examination. You may also have imaging or blood tests.
AS has no cure, but medicines can relieve symptoms and may keep the disease from getting worse. Eating a healthy diet, not smoking, and exercising can also help. In rare cases, you may need surgery to straighten the spine.
NIH: National Institute of Arthritis and Musculoskeletal and Skin Disease
Treatments and Therapies
- Alternative Treatments for Ankylosing Spondylitis (Spondylitis Association of America)
- Disease Modifying Antirheumatic Drugs (DMARDs) (Beyond the Basics) (UpToDate)
- NSAIDs (Nonsteroidal Anti-inflammatory Drugs) (American College of Rheumatology) Also in Spanish
- Genetics Home Reference: ankylosing spondylitis (National Library of Medicine)
- ClinicalTrials.gov: Spondylitis, Ankylosing (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing...
- Article: Genetic variants of TREML2 are associated with HLA-B27-positive ankylosing spondylitis.
- Article: A retrospective study of alendronate for the treatment of ankylosing...
- Ankylosing Spondylitis -- see more articles
Find an Expert
- Arthritis Foundation Also in Spanish
- Find a Rheumatologist (American College of Rheumatology)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish
- Spondylitis Web Info for Teens (Spondylitis Association of America)