Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build up in areas of the brain. The disease may cause a wide range of symptoms, including
- Changes in alertness and attention
- Problems with movement and posture
- Muscle stiffness
- Loss of memory
Lewy body disease can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.
Lewy body disease usually begins between the ages of 50 and 85. The disease gets worse over time. There is no cure. Treatment focuses on drugs to help symptoms.
NIH: National Institute of Neurological Disorders and Stroke
- 10 Things You Should Know About LBD (Lewy Body Dementia Association)
- Dementia with Lewy Bodies (National Institute of Neurological Disorders and Stroke)
- Lewy Body Dementia (Mayo Foundation for Medical Education and Research) Also in Spanish
- Lewy Body Dementia: Information for Patients, Families, and Professionals (National Institute on Aging)
Treatments and Therapies
- Lewy Body Disease Treatment (Lewy Body Dementia Association)
- Caregiver FAQ (Lewy Body Dementia Association)
- Genetics Home Reference: dementia with Lewy bodies (National Library of Medicine)
- ClinicalTrials.gov: Lewy Body Disease (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Advances in the pharmacotherapeutic management of dementia with Lewy bodies.
- Article: Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of...
- Article: Neuropsychiatric symptoms and α-Synuclein profile of patients with Parkinson's disease...
- Lewy Body Disease -- see more articles