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Kaposi's sarcoma (KS) is a cancer that causes patches of abnormal tissue to grow under the skin, in the lining of the mouth, nose, and throat, in lymph nodes, or in other organs. These patches, or lesions, are usually red or purple. They are made of cancer cells, blood vessels, and blood cells.
KS is caused by infection with human herpesvirus-8 (HHV-8). Most people infected with HHV-8 don't get KS. It usually happens in
- People with weak immune systems, due to HIV/AIDS, drugs taken after an organ transplant, or another disease
- Older men of Jewish or Mediterranean descent
- Young men in Africa
The skin lesions may not cause symptoms. But they can spread to other parts of the body, especially in people with HIV/AIDS. If they spread to the digestive tract or lungs, they can cause bleeding. Lesions on the lungs can also make it hard to breathe.
Treatment depends on where the lesions are and how bad they are. Options include radiation therapy, surgery, chemotherapy, and biologic therapy. People with HIV/AIDS also take HIV/AIDS Medicines.
NIH: National Cancer Institute
Prevention and Risk Factors
- Can Kaposi Sarcoma Be Prevented? (American Cancer Society)
- Do We Know What Causes Kaposi Sarcoma? (American Cancer Society)
- What Should You Ask Your Doctor about Kaposi Sarcoma? (American Cancer Society)
- Purplish Lesions of Kaposi's Sarcoma (National Institutes of Health)
Statistics and Research
- What Are the Key Statistics about Kaposi Sarcoma? (American Cancer Society)
- What's New in Kaposi Sarcoma Research and Treatment? (American Cancer Society)
- ClinicalTrials.gov: Sarcoma, Kaposi (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection:...
- Article: The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is...
- Article: Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion...
- Kaposi's Sarcoma -- see more articles
- After chemotherapy - discharge (Medical Encyclopedia) Also in Spanish
- Kaposi sarcoma (Medical Encyclopedia) Also in Spanish
- Understanding Chemotherapy (National Cancer Institute) - PDF Also in Spanish
- What to Know about External Beam Radiation Therapy (National Cancer Institute) - PDF Also in Spanish