Progressive supranuclear palsy (PSP) is a rare brain disease. It affects brain cells that control the movement of your eyes. This leads to serious and permanent problems with balance and the way you walk. It usually occurs in middle-aged or elderly people. Symptoms are very different in each person, but may include personality changes, speech, vision and swallowing problems. Doctors sometimes confuse PSP with Parkinson's disease or Alzheimer's disease.
PSP has no cure and no effective treatments. Walking aids, special glasses and certain medicines might help somewhat. Although the disease gets worse over time, it isn't fatal on its own. However, PSP is dangerous because it increases your risk of pneumonia and choking from swallowing problems and injuries from falling.
NIH: National Institute of Neurological Disorders and Stroke
- Progressive supranuclear palsy (Medical Encyclopedia) Also in Spanish
- Progressive Supranuclear Palsy (National Institute of Neurological Disorders and Stroke) - Short Summary
- Progressive Supranuclear Palsy (National Institute of Neurological Disorders and Stroke) Also in Spanish
- Progressive Supranuclear Palsy (PSP): Frequently Asked Questions (Foundation for PSP/CBD and Related Brain Diseases)
- Genetics Home Reference: progressive supranuclear palsy (National Library of Medicine)
- ClinicalTrials.gov: Supranuclear Palsy, Progressive (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Preclinical, phase I, and phase II investigational clinical trials for...
- Article: CSF biomarkers β-amyloid, tau proteins and a-synuclein in the differential...
- Article: Natural history and predictors of survival in progressive supranuclear palsy.
- Progressive Supranuclear Palsy -- see more articles