What is progressive supranuclear palsy (PSP)?
Progressive supranuclear palsy (PSP) is a rare brain disease. It happens because of damage to nerve cells in the brain. PSP affects your movement, including control of your walking and balance. It also affects your thinking and eye movement.
PSP is progressive, which means that it gets worse over time.
What causes progressive supranuclear palsy (PSP)?
Researchers don't know what causes most cases of PSP. In rare cases, the cause is a mutation in a certain gene.
One sign of PSP is abnormal clumps of tau in nerve cells in the brain. Tau is a protein in your nervous system, including in nerve cells. Some other diseases also cause a buildup of tau in the brain, including Alzheimer's disease.
Who is at risk for progressive supranuclear palsy (PSP)?
PSP usually affects people over 60, but in some cases it can start earlier. It is more common in men.
What are the symptoms of progressive supranuclear palsy (PSP)?
Symptoms are very different in each person, but they may include
- A loss of balance while walking. This is often the first symptom.
- Speech problems
- Trouble swallowing
- A blurring of vision and problems controlling eye movement
- Changes in mood and behavior, including depression and apathy (a loss of interest and enthusiasm)
- Mild dementia
How is progressive supranuclear palsy (PSP0 diagnosed?
There is no specific test for PSP. It can be difficult to diagnose, because the symptoms are similar to other diseases such as Parkinson's disease and Alzheimer's disease.
To make a diagnosis, your health care provider will take your medical history and do physical and neurological exams. You may have an MRI or other imaging tests.
What are the treatments for progressive supranuclear palsy (PSP)?
There is currently no effective treatment for PSP. Medicines may reduce some symptoms. Some non-drug treatments, such as walking aids and special glasses, may also help. People with severe swallowing problems may need gastrostomy. This is a surgery to insert a feeding tube into the stomach.
PSP gets worse over time. Many people become severely disabled within three to five years after getting it. PSP isn't life-threatening on its own. It can still be be dangerous, because it increases your risk of pneumonia, choking from swallowing problems, and injuries from falling. But with good attention to medical and nutritional needs, many people with PSP can live 10 or more years after the first symptoms of the disease.
NIH: National Institute of Neurological Disorders and Stroke
- Progressive supranuclear palsy (Medical Encyclopedia) Also in Spanish
- Progressive Supranuclear Palsy (National Institute of Neurological Disorders and Stroke) - Short Summary
- Progressive Supranuclear Palsy (National Institute of Neurological Disorders and Stroke) Also in Spanish
- Progressive Supranuclear Palsy (PSP): Frequently Asked Questions (Foundation for PSP/CBD and Related Brain Diseases)
- Genetics Home Reference: progressive supranuclear palsy (National Library of Medicine)
- ClinicalTrials.gov: Supranuclear Palsy, Progressive (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation.
- Article: Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains...
- Article: SPECT Molecular Imaging in Atypical Parkinsonism.
- Progressive Supranuclear Palsy -- see more articles