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Summary
Hemophilia is a rare disorder in which the blood does not clot normally. It is usually inherited. Hemophilia usually occurs in males.
If you have hemophilia, you have little or no clotting factor. Clotting factor is a protein needed for normal blood clotting. Without it, you may bleed for a long time after an injury or accident. You also may bleed into your knees, ankles, and elbows. Bleeding in the joints causes pain and, if not treated, can lead to arthritis. Bleeding in the brain, a very serious complication of hemophilia, requires emergency treatment.
The main symptoms of hemophilia are excessive bleeding and easy bruising. Blood tests can tell if you have it. The main treatment is injecting the missing clotting factor into the bloodstream. You may need it on a regular basis, or just when bleeding occurs.
NIH: National Heart, Lung, and Blood Institute
Diagnosis and Tests
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Coagulation Factor Tests
(National Library of Medicine) Also in Spanish
- Fibrinogen Test (American Association for Clinical Chemistry)
- Hemophilia Diagnosis (Centers for Disease Control and Prevention) Also in Spanish
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Partial Thromboplastin Time (PTT) Test
(National Library of Medicine) Also in Spanish
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Prothrombin Time Test and INR (PT/INR)
(National Library of Medicine) Also in Spanish
Treatments and Therapies
- Hemophilia Treatments Have Come a Long Way (Food and Drug Administration) Also in Spanish
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What Is a Blood Transfusion?
(National Heart, Lung, and Blood Institute)
Related Issues
- Carriers and Women with Hemophilia (World Federation of Hemophilia)
- Inhibitors (Centers for Disease Control and Prevention)
Genetics
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hemophilia: MedlinePlus Genetics
(National Library of Medicine)
Statistics and Research
- Hemophilia Data and Statistics (Centers for Disease Control and Prevention)
Clinical Trials
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ClinicalTrials.gov: Blood Coagulation Disorders
(National Institutes of Health)
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ClinicalTrials.gov: Hemophilia A
(National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Phase 4 Safety and Efficacy Study of Antihemophilic Factor (Recombinant) in...
- Article: Epidemiological Challenges in Rare Bleeding Disorders: FVIII Inhibitor Incidence in Haemophilia...
- Article: Morphological characteristics and clinical significance of the distal femur in patients...
- Hemophilia -- see more articles
Find an Expert
- Find a Hematologist (American Society of Hematology)
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National Heart, Lung, and Blood Institute
Children
- Hemophilia (For Parents) (Nemours Foundation)
Women
- Carriers and Women with Hemophilia (World Federation of Hemophilia)
Patient Handouts
- Hemophilia (Medical Encyclopedia) Also in Spanish
- Hemophilia A (Medical Encyclopedia) Also in Spanish
- Hemophilia B (Medical Encyclopedia) Also in Spanish
- Partial thromboplastin time (PTT) (Medical Encyclopedia) Also in Spanish