Transient tachypnea of the newborn (TTN) is a breathing disorder seen shortly after delivery in early term or late preterm babies.
- Transient means it is short-lived (most often less than 48 hours).
- Tachypnea means rapid breathing (faster than most newborns, who normally breathe 40 to 60 times per minute).
As the baby grows in the womb, the lungs make a special fluid. This fluid fills the baby's lungs and helps them grow. When the baby is born at term, hormones released during labor tell the lungs to stop making this special fluid. The baby's lungs start removing or reabsorbing it.
The first few breaths a baby takes after delivery fill the lungs with air and help to clear most of the remaining lung fluid.
Leftover fluid in the lungs causes the baby to breathe rapidly. It is harder for the small air sacs of the lungs to stay open.
TTN is more likely to occur in babies who were:
- Born before 38 completed weeks gestation (early term)
- Delivered by C-section, especially if labor has not already started
- Born to a mother with diabetes or asthma
- Male gender
Exams and Tests
The mother's pregnancy and labor history are important to make the diagnosis.
Tests performed on the baby may include:
- Blood count and blood culture to rule out infection
- Chest x-ray to rule out other causes of breathing problems
- Blood gas to check levels of carbon dioxide and oxygen
- Continuous monitoring of the baby's oxygen levels, breathing, and heart rate
The diagnosis of TTN is most often made after the baby is monitored for 2 or 3 days. If the condition goes away in that time, it is considered to be transient.
Your baby will be given oxygen to keep the blood oxygen level stable. Your baby will often need the most oxygen within a few hours after birth. The baby's oxygen needs will begin to decrease after that. Most infants with TTN improve in less than 24 to 48 hours, but some will need help for a few days.
Very rapid breathing usually means a baby is unable to eat. Fluids and nutrients will be given through a vein until your baby improves. Your baby may also receive antibiotics until the health care provider is sure there is no infection. Rarely, babies with TTN will need help with breathing or feeding a week or more.
The condition most often goes away within 48 to 72 hours after delivery. In most cases, babies who have had TTN have no further problems from the condition. They will not need special care or follow-up other than their routine checkups. However, there is some evidence that babies with TTN may be at a higher risk for wheezing problems later in infancy.
Late preterm or early term babies (born more than 2 to 6 weeks before their due date) who have been delivered by C-section without labor may be at risk for a more severe form known as "malignant TTN."
TTN; Wet lungs - newborns; Retained fetal lung fluid; Transient RDS; Prolonged transition; Neonatal - transient tachypnea
Ahlfeld SK. Respiratory tract disorders. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 122.
Crowley MA. Neonatal respiratory disorders. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. 11th ed. Philadelphia, PA: Elsevier Saunders; 2020:chap 66.
Greenberg JM, Haberman BE, Narendran V, Nathan AT, Schibler K. Neonatal morbidities of prenatal and perinatal origin. In: Creasy RK, Lockwood CJ, Moore TR, Greene MF, Copel JA, Silver RM, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. 8th ed. Philadelphia, PA: Elsevier Saunders; 2019:chap 73.
Review Date 9/29/2019
Updated by: Kimberly G. Lee, MD, MSc, IBCLC, Clinical Professor of Pediatrics, Division of Neonatology, Medical University of South Carolina, Charleston, SC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.