Respiratory alkalosis is a condition marked by a low level of carbon dioxide in the blood due to breathing excessively.
Common causes include:
- Anxiety or panic
- Overbreathing (hyperventilation)
- Pregnancy (this is normal)
- Severe anemia
- Liver disease
- Overdose of certain medicines, such as salicylates, progesterone
Any lung disease that leads to shortness of breath can also cause respiratory alkalosis (such as pulmonary embolism and asthma).
The symptoms may include:
- Numbness of the hands and feet
- Chest discomfort
Treatment is aimed at the condition that causes respiratory alkalosis. Breathing into a paper bag -- or using a mask that causes you to re-breathe carbon dioxide -- sometimes helps reduce symptoms when anxiety is the main cause of the condition.
Outlook depends on the condition that is causing the respiratory alkalosis.
Seizures may occur if the alkalosis is extremely severe. This is very rare and more likely to happen if the alkalosis is due to increased ventilation from a breathing machine.
When to Contact a Medical Professional
Call your provider if you have any symptoms of lung disease, such as long-term (chronic) cough or shortness of breath.
Alkalosis - respiratory
Effros RM, Swenson ER. Acid-base balance. In: Broaddus VC, Mason RJ, Ernst JD, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 7.
Seifter JL. Acid-base disorders. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 110.
Strayer RJ. Acid-base disorders. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 116.
Review Date 8/3/2020
Updated by: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.