Dirección de esta página: https://medlineplus.gov/spanish/druginfo/natural/905.html

Hongo Reishi

¿Qué es?

El hongo reishi (Ganoderma lucidum) es un hongo de sabor amargo sin beneficios para la salud comprobados. Se cree que tiene algunos efectos sobre el sistema inmunológico.

El hongo reishi se usa para la enfermedad de Alzheimer, el cáncer, la diabetes, el herpes labial y muchas otras condiciones, pero no existe una buena evidencia científica que respalde estos usos.

¿Qué tan efectivo es?

Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.

La clasificación de la eficacia para este producto es la siguiente:

Posiblemente ineficaz para...

  • Niveles altos de colesterol u otras grasas (lípidos) en la sangre (hiperlipidemia). La ingesta de hongos reishi no parece reducir los niveles de colesterol en personas con diabetes o colesterol alto
Existe interés en usar el hongo reishi para otros propósitos, pero no hay suficiente información confiable para decir si podría ser útil.

¿Es seguro?

Cuando se toma por vía oral: El extracto de hongo Reishi es posiblemente seguro cuando se usa hasta por un año. El hongo reishi entero en polvo es posiblemente seguro cuando se usa hasta por 16 semanas. El hongo reishi puede causar mareos, sequedad de boca, picazón, náuseas, malestar estomacal y sarpullido.

Advertencias y precauciones especiales:

Embarazo y lactancia: No hay suficiente información confiable para saber si el hongo reishi es seguro de usar durante el embarazo o la lactancia. Manténgase en el lado seguro y evite su uso.

Trastornos hemorrágicos: Las dosis altas de hongo reishi pueden aumentar el riesgo de hemorragia en algunas personas con ciertos trastornos hemorrágicos.

Cirugía: Las dosis altas de hongo reishi pueden aumentar el riesgo de hemorragia en algunas personas si se usan antes o durante la cirugía. Deje de usar el hongo reishi al menos 2 semanas antes de una cirugía programada.

¿Existen interacciones con medicamentos?

Moderadas
Tenga cuidado con esta combinación
Medicamentos para la diabetes (medicamentos antidiabéticos)
El hongo reishi podría reducir los niveles de azúcar en sangre. La ingesta de hongos reishi junto con medicamentos para la diabetes puede hacer que el azúcar en sangre baje demasiado. Controle de cerca su nivel de azúcar en sangre.
Medicamentos para la presión arterial alta (medicamentos antihipertensivos)
El hongo reishi podría reducir la presión arterial. La ingesta de hongos reishi junto con medicamentos que reducen la presión arterial puede hacer que la presión arterial baje demasiado. Controle su presión arterial de cerca.
Medicamentos que retardan la coagulación de la sangre (medicamentos anticoagulantes / antiplaquetarios)
El hongo reishi podría retardar la coagulación sanguínea. La ingesta de hongos reishi junto con medicamentos que también retardan la coagulación de la sangre podría aumentar el riesgo de hematomas y hemorragias.

¿Existen interacciones con hierbas y suplementos?

Hierbas y suplementos que pueden reducir el azúcar en sangre
El hongo reishi podría reducir el azúcar en sangre. Tomarlo con otros suplementos con efectos similares podría reducir demasiado el azúcar en sangre. Ejemplos de suplementos con este efecto incluyen aloe, melón amargo, canela casia, cromo y nopal.
Hierbas y suplementos que pueden reducir la presión arterial
El hongo reishi podría reducir la presión arterial. Tomarlo con otros suplementos que tienen el mismo efecto puede hacer que la presión arterial baje demasiado. Ejemplos de suplementos con este efecto incluyen andrographis, péptidos de caseína, L-arginina, niacina y ortiga.
Hierbas y suplementos que pueden retardar la coagulación sanguínea
El hongo reishi podría retardar la coagulación sanguínea y aumentar el riesgo de hemorragia. Tomarlo con otros suplementos con efectos similares podría aumentar el riesgo de hemorragia en algunas personas. Ejemplos de suplementos con este efecto incluyen ajo, jengibre, ginkgo, nattokinasa y Panax ginseng.

¿Existen interacciones con alimentos?

No se conoce ninguna interacción con alimentos.

¿Como se usa normalmente?

El hongo reishi ha sido utilizado con mayor frecuencia por adultos en dosis de 1400-5400 mg por vía oral al día, generalmente en dosis divididas. Los extractos de hongos reishi también se han utilizado en dosis más bajas. Hable con un proveedor de atención médica para averiguar qué dosis podría ser la mejor para una condición específica.

Otros nombres

Basidiomycetes Mushroom, Champignon Basidiomycète, Champignon d’Immortalité, Champignon Reishi, Champignons Reishi, Ganoderma, Ganoderma lucidum, Ling Chih, Ling Zhi, Mannentake, Mushroom, Mushroom of Immortality, Mushroom of Spiritual Potency, Red Reishi, Reishi, Reishi Antler Mushroom, Reishi Rouge, Rei-Shi, Spirit Plant.

Metodología

Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

Referencias

  1. Zhong L, Yan P, Lam WC, et al. Coriolus versicolor and Ganoderma lucidum related natural products as an adjunct therapy for cancers: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol 2019;10:703. View abstract.
  2. Wang GH, Wang LH, Wang C, Qin LH. Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.Medicine (Baltimore). 2018 May;97:e0636. doi: 10.1097/MD.0000000000010636. View abstract.
  3. Wu DT, Deng Y, Chen LX. Evaluation on quality consistency of Ganoderma lucidum dietary supplements collected in the United States. Sci Rep. 2017 Aug 10;7:7792. doi: 10.1038/s41598-017-06336-3. View abstract.
  4. Ríos JL, Andújar I, Recio MC, Giner RM. Lanostanoids from fungi: a group of potential anticancer compounds. J Nat Prod. 2012 Nov 26;75:2016-44. View abstract.
  5. Hennicke F, Cheikh-Ali Z, Liebisch T, Maciá-Vicente JG, Bode HB, Piepenbring M. Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles. Phytochemistry. 2016 Jul;127:29-37. View abstract.
  6. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. View abstract.
  7. Noguchi M, Kakuma T, Tomiyasu K, Yamada A, Itoh K, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Asian J Androl. 2008 Sep;10:777-85. View abstract.
  8. Noguchi M, Kakuma T, Tomiyasu K, Kurita Y, Kukihara H, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Asian J Androl. 2008 Jul;10:651-8. View abstract.
  9. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. View abstract.
  10. Hijikata Y, Yamada S, Yasuhara A. Herbal mixtures containing the mushroom Ganoderma lucidum improve recovery time in patients with herpes genitalis and labialis. J Altern Complement Med. 2007 Nov;13:985-7. View abstract.
  11. Donatini B. Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial. Int J Med Mushrooms. 2014;16:497-8. View abstract.
  12. Mizuno, T. Bioactive biomolecules of mushrooms: food function and medicinal effect of mushroom fungi. Fd Rev Internat 1995;11:7-21.
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asian Traditional Medicine. New York: Elsevier Science;1996.
  14. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6.
  15. Gao, Y., Chen, G., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Coronary Heart Disease. International Journal of Medicinal Mushrooms 2004.
  16. Gao, Y., Zhou, S., Chen, G., Dai, X., Ye, J., and Gao, H. A Phase I/II Study of a Ganoderma lucidum(Curt.:Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) Extract in Patients with Chronic Hepatitis BÂ. InternationalJournal ofMedicinalMushrooms 2002;4:2321-7.
  17. Gao, Y., Zhou, S., Chen, G., Dai, X., and Ye, J. A Phase I/II Study of a
  18. Gao, Y., Dai, X., Chen, G., Ye, J., and Zhou, S. A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer. International Journal of Medicinal Mushrooms 2003;5.
  19. Zhang X, Jia Y Li Q Niu S Zhu S Shen C. Clinical curative effect investigation of Lingzhi tablet on lung cancer. Chinese Traditional Patent Medicine 2000;22:486-488.
  20. Yan B, Wei Y Li Y. Effect of Laojunxian Lingzhi oral liquid combined with chemotherapy on non-parvicellular lung cancer at stage II and III. Traditional Chinese Drug Research & Clinical Pharmacology 1998;9:78-80.
  21. Leng K, LuM. Investigation of ZhengQing Lingzhi liquid as adjuvant treatment on patients with colon cancer. Journal of Guiyang Medical College 2003;28:1.
  22. He W, Yi J. Study of clinical efficacy of Lingzhi spore capsule on tumour patients with chemotherapy/radiotherapy. Clinical Journal of Traditional Chinese Medicine 1997;9:292-293.
  23. Park, E. J., Ko, G., Kim, J., and Sohn, D. H. Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction. Biol Pharm Bull. 1997;20:417-420. View abstract.
  24. Kawagishi, H., Mitsunaga, S., Yamawaki, M., Ido, M., Shimada, A., Kinoshita, T., Murata, T., Usui, T., Kimura, A., and Chiba, S. A lectin from mycelia of the fungus Ganoderma lucidum. Phytochemistry 1997;44:7-10. View abstract.
  25. van der Hem, L. G., van der Vliet, J. A., Bocken, C. F., Kino, K., Hoitsma, A. J., and Tax, W. J. Prolongation of allograft survival with Ling Zhi-8, a new immunosuppressive drug. Transplant.Proc. 1994;26:746. View abstract.
  26. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105:942-947. View abstract.
  27. Shimizu, A., Yano, T., Saito, Y., and Inada, Y. Isolation of an inhibitor of platelet aggregation from a fungus, Ganoderma lucidum. Chem Pharm Bull.(Tokyo) 1985;33:3012-3015. View abstract.
  28. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34:433-438. View abstract.
  29. Morigiwa, A., Kitabatake, K., Fujimoto, Y., and Ikekawa, N. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem Pharm Bull.(Tokyo) 1986;34:3025-3028. View abstract.
  30. Hikino, H. and Mizuno, T. Hypoglycemic actions of some heteroglycans of Ganoderma lucidum fruit bodies. Planta Med 1989;55:385. View abstract.
  31. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731. View abstract.
  32. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107:1017-1027. View abstract.
  33. Oka, S., Tanaka, S., Yoshida, S., Hiyama, T., Ueno, Y., Ito, M., Kitadai, Y., Yoshihara, M., and Chayama, K. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Hiroshima J.Med.Sci. 2010;59:1-6. View abstract.
  34. Liu, J., Shiono, J., Shimizu, K., Kukita, A., Kukita, T., and Kondo, R. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg.Med.Chem.Lett. 4-15-2009;19:2154-2157. View abstract.
  35. Zhuang, S. R., Chen, S. L., Tsai, J. H., Huang, C. C., Wu, T. C., Liu, W. S., Tseng, H. C., Lee, H. S., Huang, M. C., Shane, G. T., Yang, C. H., Shen, Y. C., Yan, Y. Y., and Wang, C. K. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother.Res. 2009;23:785-790. View abstract.
  36. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine. 2009;16:426-436. View abstract.
  37. Lin, C. N., Tome, W. P., and Won, S. J. Novel cytotoxic principles of Formosan Ganoderma lucidum. J Nat Prod 1991;54:998-1002. View abstract.
  38. Li, E. K., Tam, L. S., Wong, C. K., Li, W. C., Lam, C. W., Wachtel-Galor, S., Benzie, I. F., Bao, Y. X., Leung, P. C., and Tomlinson, B. Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial. Arthritis Rheum 10-15-2007;57:1143-1150. View abstract.
  39. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90:179-181. View abstract.
  40. Ni, T., Hu, Y., Sun, L., Chen, X., Zhong, J., Ma, H., and Lin, Z. Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats. Int.J.Mol.Med. 2007;20:45-51. View abstract.
  41. Cheuk, W., Chan, J. K., Nuovo, G., Chan, M. K., and Fok, M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol 2007;15:180-186. View abstract.
  42. Chen, T. W., Wong, Y. K., and Lee, S. S. [In vitro cytotoxicity of Ganoderma lucidum on oral cancer cells]. Chung Hua I.Hsueh Tsa Chih (Taipei) 1991;48:54-58. View abstract.
  43. Hsu, H. Y., Hua, K. F., Lin, C. C., Lin, C. H., Hsu, J., and Wong, C. H. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways. J.Immunol. 11-15-2004;173:5989-5999. View abstract.
  44. Lu, Q. Y., Jin, Y. S., Zhang, Q., Zhang, Z., Heber, D., Go, V. L., Li, F. P., and Rao, J. Y. Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett. 12-8-2004;216:9-20. View abstract.
  45. Hong, K. J., Dunn, D. M., Shen, C. L., and Pence, B. C. Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells. Phytother.Res. 2004;18:768-770. View abstract.
  46. Lu, Q. Y., Sartippour, M. R., Brooks, M. N., Zhang, Q., Hardy, M., Go, V. L., Li, F. P., and Heber, D. Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro. Oncol.Rep. 2004;12:659-662. View abstract.
  47. Cao, Q. Z. and Lin, Z. B. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol.Sin. 2004;25:833-838. View abstract.
  48. Jiang, J., Slivova, V., Valachovicova, T., Harvey, K., and Sliva, D. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Int.J.Oncol. 2004;24:1093-1099. View abstract.
  49. Lieu, C. W., Lee, S. S., and Wang, S. Y. The effect of Ganoderma lucidum on induction of differentiation in leukemic U937 cells. Anticancer Res. 1992;12:1211-1215. View abstract.
  50. Berger, A., Rein, D., Kratky, E., Monnard, I., Hajjaj, H., Meirim, I., Piguet-Welsch, C., Hauser, J., Mace, K., and Niederberger, P. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. Lipids Health Dis. 2-18-2004;3:2. View abstract.
  51. Wachtel-Galor, S., Tomlinson, B., and Benzie, I. F. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br.J.Nutr. 2004;91:263-269. View abstract.
  52. Iwatsuki, K., Akihisa, T., Tokuda, H., Ukiya, M., Oshikubo, M., Kimura, Y., Asano, T., Nomura, A., and Nishino, H. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. J.Nat.Prod. 2003;66:1582-1585. View abstract.
  53. Wachtel-Galor, S., Szeto, Y. T., Tomlinson, B., and Benzie, I. F. Ganoderma lucidum ('Lingzhi'); acute and short-term biomarker response to supplementation. Int.J.Food Sci.Nutr. 2004;55:75-83. View abstract.
  54. Sliva, D., Sedlak, M., Slivova, V., Valachovicova, T., Lloyd, F. P., Jr., and Ho, N. W. Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells. J.Altern.Complement Med. 2003;9:491-497. View abstract.
  55. Hsu, M. J., Lee, S. S., Lee, S. T., and Lin, W. W. Signaling mechanisms of enhanced neutrophil phagocytosis and chemotaxis by the polysaccharide purified from Ganoderma lucidum. Br.J.Pharmacol. 2003;139:289-298. View abstract.
  56. Xiao, G. L., Liu, F. Y., and Chen, Z. H. [Clinical observation on treatment of Russula subnigricans poisoning patients by Ganoderma lucidum decoction]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23:278-280. View abstract.
  57. Sliva, D., Labarrere, C., Slivova, V., Sedlak, M., Lloyd, F. P., Jr., and Ho, N. W. Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem.Biophys.Res.Commun. 11-8-2002;298:603-612. View abstract.
  58. Hu, H., Ahn, N. S., Yang, X., Lee, Y. S., and Kang, K. S. Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int.J.Cancer 11-20-2002;102:250-253. View abstract.
  59. Futrakul, N., Boongen, M., Tosukhowong, P., Patumraj, S., and Futrakul, P. Treatment with vasodilators and crude extract of Ganoderma lucidum suppresses proteinuria in nephrosis with focal segmental glomerulosclerosis. Nephron 2002;92:719-720. View abstract.
  60. Zhong, L., Jiang, D., and Wang, Q. [Effects of Ganoderma lucidum (Leyss ex Fr) Karst compound on the proliferation and differentiation of K562 leukemic cells]. Hunan.Yi.Ke.Da.Xue.Xue.Bao. 1999;24:521-524. View abstract.
  61. Gao, J. J., Min, B. S., Ahn, E. M., Nakamura, N., Lee, H. K., and Hattori, M. New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chem.Pharm.Bull.(Tokyo) 2002;50:837-840. View abstract.
  62. Ma, J., Ye, Q., Hua, Y., Zhang, D., Cooper, R., Chang, M. N., Chang, J. Y., and Sun, H. H. New lanostanoids from the mushroom Ganoderma lucidum. J.Nat.Prod. 2002;65:72-75. View abstract.
  63. Min, B. S., Gao, J. J., Hattori, M., Lee, H. K., and Kim, Y. H. Anticomplement activity of terpenoids from the spores of Ganoderma lucidum. Planta Med. 2001;67:811-814. View abstract.
  64. Lee, J. M., Kwon, H., Jeong, H., Lee, J. W., Lee, S. Y., Baek, S. J., and Surh, Y. J. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 2001;15:245-249. View abstract.
  65. Zhu, H. S., Yang, X. L., Wang, L. B., Zhao, D. X., and Chen, L. Effects of extracts from sporoderm-broken spores of Ganoderma lucidum on HeLa cells. Cell Biol.Toxicol. 2000;16:201-206. View abstract.
  66. Eo, S. K., Kim, Y. S., Lee, C. K., and Han, S. S. Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses. J Ethnopharmacol. 2000;72:475-481. View abstract.
  67. Su, C., Shiao, M., and Wang, C. Potentiation of ganodermic acid S on prostaglandin E-induced cyclic AMP elevation in human platelets. Thromb.Res 7-15-2000;99:135-145. View abstract.
  68. Yun, T. K. Update from Asia. Asian studies on cancer chemoprevention. Ann.N.Y Acad.Sci. 1999;889:157-192. View abstract.
  69. Mizushina, Y., Takahashi, N., Hanashima, L., Koshino, H., Esumi, Y., Uzawa, J., Sugawara, F., and Sakaguchi, K. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg.Med.Chem. 1999;7:2047-2052. View abstract.
  70. Kim, K. C. and Kim, I. G. Ganoderma lucidum extract protects DNA from strand breakage caused by hydroxyl radical and UV irradiation. Int J Mol.Med 1999;4:273-277. View abstract.
  71. Olaku, O. and White, J. D. Herbal therapy use by cancer patients: a literature review on case reports. Eur.J.Cancer 2011;47:508-514. View abstract.
  72. Haniadka, R., Popouri, S., Palatty, P. L., Arora, R., and Baliga, M. S. Medicinal plants as antiemetics in the treatment of cancer: a review. Integr.Cancer Ther. 2012;11:18-28. View abstract.
  73. Gao Y, Zhou S, Jiang W, et al. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest 2003;32:201-15. View abstract.
  74. Yuen JW, Gohel MD. Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutr Cancer 2005;53:11-7. View abstract.
  75. Sun J, He H, Xie BJ. Novel antioxidant peptides from fermented mushroom Ganoderma lucidum. J Agric Food Chem 2004;52:6646-52. View abstract.
  76. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. View abstract.
  77. van der Hem LG, van der Vliet JA, Bocken CF, et al. Ling Zhi-8: studies of a new immunomodulating agent. Transplantation 1995;60:438-43. View abstract.
  78. Yoon SY, Eo SK, Kim YS, et al. Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics. Arch Pharm Res 1994;17:438-42. View abstract.
  79. Kim DH, Shim SB, Kim NJ, et al. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Biol Pharm Bull 1999;22:162-4. View abstract.
  80. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. View abstract.
  81. Hikino H, Ishiyama M, Suzuki Y, et al. Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med 1989;55:423-8. View abstract.
  82. Komoda Y, Shimizu M, Sonoda Y, et al. Ganoderic acid and its derivatives as cholesterol synthesis inhibitors. Chem Pharm Bull (Tokyo) 1989;37:531-3. View abstract.
  83. Hijikata Y, Yamada S. Effect of Ganoderma lucidum on postherpetic neuralgia. Am J Chin Med 1998;26:375-81. View abstract.
  84. Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor). Carcinogenesis 1999;20:1637-40. View abstract.
  85. Wang SY, Hsu ML, Hsu HC, et al. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 1997;70:699-705. View abstract.
  86. Kim RS, Kim HW, Kim BK. Suppressive effects of Ganoderma lucidum on proliferation of peripheral blood mononuclear cells. Mol Cells 1997;7:52-7. View abstract.
  87. el-Mekkawy S, Meselhy MR, Nakamura N, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochem 1998;49:1651-7. View abstract.
  88. Min BS, Nakamura N, Miyashiro H, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem Pharm Bull (Tokyo) 1998;46:1607-12. View abstract.
  89. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7. View abstract.
  90. Gau JP, Lin CK, Lee SS, et al. The lack of antiplatelet effect of crude extracts from ganoderma lucidum on HIV-positive hemophiliacs. Am J Chin Med 1990;18:175-9. View abstract.
  91. Wasser SP, Weis AL. Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective. Crit Rev Immunol 1999;19:65-96. View abstract.
  92. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. View abstract.
  93. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
Documento revisado - 01/24/2022