URL of this page: https://medlineplus.gov/druginfo/natural/905.html

Reishi Mushroom

What is it?

Reishi mushroom is a fungus. Some people describe it as "tough" and "woody" with a bitter taste. The above-ground part and portions of the below-ground parts are used as medicine.

Reishi mushroom is used for cancer, boosting the immune system to prevent or treat infections, and for many other conditions, but there is no good scientific evidence to support these uses.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for REISHI MUSHROOM are as follows:

Possibly ineffective for...

  • High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Reishi mushroom does not seem to lower cholesterol in people with diabetes, high blood pressure, or high cholesterol.

Insufficient evidence to rate effectiveness for...

  • Alzheimer disease. Early research shows that taking reishi mushroom powder does not improve memory or quality of life in people with Alzheimer disease.
  • Enlarged prostate (benign prostatic hyperplasia or BPH). Men with enlarged prostates often have urinary symptoms. Taking reishi mushroom extract can improve some urinary symptoms such as the need to urinate often or immediately. But other symptoms such as urine flow rate don't seem to improve.
  • Tiredness in people with cancer. Early research shows that taking reishi mushroom powder reduces tiredness in people with breast cancer.
  • Noncancerous growth in the large intestine and rectum (colorectal adenoma). Early research shows that taking reishi mushroom extract can reduce the number and size of these tumors.
  • Heart disease. Early research shows that taking reishi mushroom extract (Ganopoly) reduces chest pain and shortness of breath in people with heart disease.
  • Diabetes. Most research shows that taking reishi mushroom extract doesn't improve blood sugar control in people with diabetes. But most of these studies were small, and some conflicting results exist.
  • Genital herpes. Early research shows that taking a mixture of reishi mushroom and other ingredients reduces the time needed for herpes outbreaks to heal.
  • Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Early research shows that taking reishi mushroom (Ganopoly) reduces how much of the hepatitis B virus is in the body. This product also seems to improve liver function in people with this condition.
  • Cold sores (herpes labialis). Early research shows that taking a mixture of reishi mushroom and other ingredients reduces the time needed for cold sores to heal.
  • High blood pressure. Taking reishi mushroom doesn't seem to lower blood pressure in people with only slightly high blood pressure. But it seems to lower blood pressure in people with more severe high blood pressure.
  • Lung cancer. Early research shows that taking reishi mushroom does not shrink lung tumors. But it might improve immune function and quality of life in people with lung cancer.
  • A sexually transmitted infection that can lead to genital warts or cancer (human papilloma virus or HPV).
  • Aging.
  • Altitude sickness.
  • Asthma.
  • Swelling (inflammation) of the main airways in the lungs (bronchitis).
  • Cancer.
  • Chronic fatigue syndrome (CFS).
  • Long-term kidney disease (chronic kidney disease or CKD).
  • Heart disease.
  • Influenza.
  • Insomnia.
  • Nerve pain caused by shingles (postherpetic neuralgia).
  • Shingles (herpes zoster).
  • Stomach ulcers.
  • Stress.
  • Other conditions.
More evidence is needed to rate the effectiveness of reishi mushroom for these uses.

How does it work?

Reishi mushroom contains chemicals that seem to have activity against tumors (cancer) and beneficial effects on the immune system.

Are there safety concerns?

When taken by mouth: Reishi mushroom extract is POSSIBLY SAFE when taken appropriately for up to one year. Powdered whole reishi mushroom is POSSIBLY SAFE when taken appropriately for up to 16 weeks. Reishi mushroom can cause dizziness, dry mouth, itching, nausea, stomach upset, and rash.

Special precautions & warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if reishi mushroom is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Bleeding disorders: High doses of reishi mushroom might increase the risk of bleeding in some people with certain bleeding disorders.

Low blood pressure: Reishi mushroom might lower blood pressure. There is a concern that it might make low blood pressure worse. If your blood pressure is too low, it is best to avoid reishi mushroom.

Surgery: High doses of reishi mushroom might increase the risk of bleeding in some people if used before or during surgery. Stop using reishi mushroom at least 2 weeks before a scheduled surgery.

Are there interactions with medications?

Be cautious with this combination.
Medications for diabetes (Antidiabetes drugs)
Reishi mushroom might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking reishi mushroom along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Medications for high blood pressure (Antihypertensive drugs)
Reishi mushroom might decrease blood pressure in some people. Taking reishi mushroom along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
High doses of reishi mushroom might slow blood clotting. Taking reishi mushroom along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood pressure
Reishi mushroom might lower blood pressure. Taking it along with other herbs and supplements that have this same effect might make blood pressure drop too low. Some of these herbs and supplements include andrographis, casein peptides, cat's claw, coenzyme Q-10, fish oil, L-arginine, lycium, stinging nettle, theanine, and others.
Herbs and supplements that might lower blood sugar
Reishi mushroom might lower blood sugar. Using it along with other herbs and supplements that have the same effect might cause blood sugar to drop too low in some people. Some of these products include alpha-lipoic acid, bitter melon, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut seed, Panax ginseng, psyllium, Siberian ginseng, and others.
Herbs and supplements that might slow blood clotting
The effect of reishi mushroom on blood clotting is not clear. Higher amounts (about 3 grams per day) but not lower doses (1.5 grams per day) might slow blood clotting. There is a concern that taking reishi mushroom along with other herbs that slow blood clotting could increase the risk of bruising and bleeding. Some of these herbs include angelica, anise, arnica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, horse chestnut, red clover, turmeric, and others.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The appropriate dose of reishi mushroom depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for reishi mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Other names

Basidiomycetes Mushroom, Champignon Basidiomycète, Champignon d'Immortalité, Champignon Reishi, Champignons Reishi, Ganoderma, Ganoderma lucidum, Hongo Reishi, Ling Chih, Ling Zhi, Mannentake, Mushroom, Mushroom of Immortality, Mushroom of Spiritual Potency, Red Reishi, Reishi, Reishi Antler Mushroom, Reishi Rouge, Rei-Shi, Spirit Plant.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


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Last reviewed - 02/02/2021