Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus.
Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients.
Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include:
- Steroids, which reduce inflammation
- Drugs that suppress the immune system response
- Antibiotics to treat associated infections
NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Pemphigus Vulgaris (VisualDX)
- ClinicalTrials.gov: Pemphigoid, Benign Mucous Membrane (National Institutes of Health)
- ClinicalTrials.gov: Pemphigoid, Bullous (National Institutes of Health)
- ClinicalTrials.gov: Pemphigus (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Hemidesmosomal Reactivity and Treatment Recommendations in Immune Checkpoint Inhibitor-Induced Bullous Pemphigoid-A...
- Article: Innate immune activation as cofactor in pemphigus disease manifestation.
- Article: Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis In Vitro...
- Pemphigus -- see more articles
Find an Expert
- Find a Dermatologist (American Academy of Dermatology)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish