Pemphigus

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Basics

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Summary

Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus.

Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients.

Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include:

• Steroids, which reduce inflammation
• Drugs that suppress the immune system response
• Antibiotics to treat associated infections

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Start Here

• Pemphigus (National Institute of Arthritis and Musculoskeletal and Skin Diseases) Also in Spanish

Specifics

• Bullous Pemphigoid (American Osteopathic College of Dermatology)
• Cicatricial Pemphigoid (American Academy of Oral and Maxillofacial Pathology) - PDF
• Hailey-Hailey Disease (Benign Chronic Pemphigus) (American Osteopathic College of Dermatology)

Images

• Pemphigus Vulgaris (VisualDX)

Clinical Trials

• ClinicalTrials.gov: Pemphigoid, Benign Mucous Membrane (National Institutes of Health)
• ClinicalTrials.gov: Pemphigoid, Bullous (National Institutes of Health)
• ClinicalTrials.gov: Pemphigus (National Institutes of Health)

Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)

• Article: Role of Human Leukocyte Antigen Class II in Antibody-Mediated Skin Disorders.
• Article: Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells...
• Pemphigus -- see more articles
• Article: Long-term efficacy and safety of dupilumab for severe bullous pemphigoid: A...

Find an Expert

• Find a Dermatologist (American Academy of Dermatology)
• National Institute of Arthritis and Musculoskeletal and Skin Diseases Also in Spanish

Patient Handouts

• Bullous pemphigoid (Medical Encyclopedia) Also in Spanish
• Pemphigus vulgaris (Medical Encyclopedia) Also in Spanish