Hemochromatosis is a disease in which too much iron builds up in your body. Your body needs iron but too much of it is toxic. If you have hemochromatosis, you absorb more iron than you need. Your body has no natural way to get rid of the extra iron. It stores it in body tissues, especially the liver, heart, and pancreas. The extra iron can damage your organs. Without treatment, it can cause your organs to fail.
There are two types of hemochromatosis. Primary hemochromatosis is an inherited disease. Secondary hemochromatosis is usually the result of something else, such as anemia, thalassemia, liver disease, or blood transfusions.
Many symptoms of hemochromatosis are similar to those of other diseases. Not everyone has symptoms. If you do, you may have joint pain, fatigue, general weakness, weight loss, and stomach pain.
Your doctor will diagnose hemochromatosis based on your medical and family histories, a physical exam, and the results from tests and procedures. Treatments include removing blood (and iron) from your body, medicines, and changes in your diet.
NIH: National Heart, Lung, and Blood Institute
Treatments and Therapies
- Iron Chelation (Aplastic Anemia & MDS International Foundation)
- Genetics Home Reference: hereditary hemochromatosis (National Library of Medicine)
- Genetics Home Reference: hypochromic microcytic anemia with iron overload (National Library of Medicine)
- Learning about Hereditary Hemochromatosis (National Human Genome Research Institute)
Videos and Tutorials
- What Is Hemochromatosis? (Dolan DNA Learning Center)
- ClinicalTrials.gov: Hemochromatosis (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Role of TfR2-Y250X and TfR1- rs3817672 Single Nucleotide Polymorphism on Pathophysiology...
- Article: Association of frequency of hereditary hemochromatosis (HFE) gene mutations (H63D and...
- Article: Unsafe Deposits: Overlapping Cutaneous Manifestations of Porphyria Cutanea Tarda, Ochronosis, Hemochromatosis,...
- Hemochromatosis -- see more articles