Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic disorder that is most common in males. About 1 in 10 African American males in the United States has it. G6PD deficiency mainly affects red blood cells, which carry oxygen from the lungs to tissues throughout the body. The most common medical problem it can cause is hemolytic anemia. That happens when red blood cells are destroyed faster than the body can replace them.
If you have G6PD deficiency, you may not have symptoms. Symptoms happen if your red blood cells are exposed to certain chemicals in food or medicine, certain bacterial or viral infections, or stress. They may include
A blood test can tell if you have it. Treatments include medicines to treat infection, avoiding substances that cause the problem with red blood cells, and sometimes transfusions.
NIH: National Library of Medicine
- G6PD Deficiency (Glucose-6-Phosphate Dehydrogenase) (For Parents) (Nemours Foundation)
- G6PD: The Test (American Association for Clinical Chemistry)
- Glucose-6-phosphate dehydrogenase deficiency (Medical Encyclopedia) Also in Spanish
- Glucose-6-Phosphate Dehydrogenase Deficiency Overview (Genetic and Rare Diseases Information Center)
- glucose-6-phosphate dehydrogenase deficiency: MedlinePlus Genetics (National Library of Medicine)
- ClinicalTrials.gov: Glucosephosphate Dehydrogenase Deficiency (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Glucose-6-phosphate dehydrogenase deficiency enhances Covid-19 infection in elderly people.
- Article: Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage...
- Article: Wide range of G6PD activities found among ethnic groups of the...
- G6PD Deficiency -- see more articles