Quantitative immunoglobulins

A blood sample is needed.

In the lab, the technician places the blood sample on special paper and applies an electric current. The proteins move on the paper and form bands that show the amount of each protein.

Follow instructions on whether or not you need to fast before this test.

Certain medicines may affect the results of this test. Your health care provider will tell you if you need to stop taking any medicines. Do not stop any medicine before talking to your provider.

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.

This test is done to look at gamma globulin protein levels in the blood. Identifying the levels of gamma globulins can help diagnose certain medical issues.

Gamma globulins include various types of antibodies such as immunoglobulins (Ig) M, G, and A.

Certain diseases are associated with producing too many immunoglobulins. For example, Waldenström macroglobulinemia is a cancer of certain white blood cells. It is linked with producing too many IgM antibodies.

Normal value ranges are:

• Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L)
• IgM component: 120 to 400 milligrams per deciliter (mg/dL) or 1.2 to 4 g/L
• IgG component: 800 to 1600 mg/dL or 8 to 16 g/L
• IgA component: 40 to 220 mg/dL or 0.4 to 2.2 g/L

Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.

Increased gamma globulin proteins may indicate:

• Acute infection
• Blood and bone marrow cancers including multiple myeloma, and some lymphomas and leukemias
• Immune deficiency disorders
• Long-term (chronic) inflammatory disease (for example, rheumatoid arthritis and systemic lupus erythematosus)
• Waldenström macroglobulinemia

There is very little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight, but may include:

• Excessive bleeding
• Fainting or feeling lightheaded
• Multiple punctures to locate veins
• Hematoma (blood buildup under the skin)
• Infection (a slight risk any time the skin is broken)

Dominiczak MH. Blood and plasma proteins. In: Baynes JW, Dominiczak MH, eds. Medical Biochemistry. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 40.

McPherson RA, Riley RS, Massey HD. Laboratory evaluation of immunoglobulin function and humoral immunity. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 47.

Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.