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Factor V deficiency

Factor V deficiency is a bleeding disorder that is passed down through families. It affects the ability of the blood to clot.

Causes

Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.

Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.

Factor V deficiency is rare. It may be caused by:

  • A defective factor V gene passed down through families (inherited)
  • An antibody that interferes with normal factor V function

You can develop an antibody that interferes with factor V:

  • After giving birth
  • After being treated with a certain type of fibrin glue
  • After surgery
  • With autoimmune diseases and certain cancers

Sometimes the cause is unknown.

The disease is similar to hemophilia, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.

Symptoms

Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include:

Exams and Tests

Tests to detect factor V deficiency include:

Treatment

You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.

Outlook (Prognosis)

The outlook is good with diagnosis and proper treatment.

Possible Complications

Severe bleeding (hemorrhage) could occur.

When to Contact a Medical Professional

Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.

Alternative Names

Parahemophilia; Owren disease; Bleeding disorder - factor V deficiency

References

Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 137.

Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 165.

Scott JP, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 503.

Review Date 1/25/2022

Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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