Factor V deficiency is a condition that is passed down through families, which affects the ability of the blood to clot.
Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors.
Factor V deficiency is caused by a lack of Factor V. When certain blood clotting factors are low or missing, your blood does not clot properly.
Factor V deficiency is rare. It may be caused by:
- A defective Factor V gene passed down through families (inherited)
- An antibody that interferes with normal Factor V function
You can get an antibody that interferes with Factor V:
- After giving birth
- After being treated with a certain type of fibrin glue
- After surgery
- With autoimmune diseases and certain cancers
Sometimes the cause is unknown.
You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.
The outlook is good with diagnosis and proper treatment.
Severe bleeding (hemorrhage) could occur.
When to Contact a Medical Professional
Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.
Parahemophilia; Owren's disease
Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 167.
Update Date 2/24/2014
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.