Drug use first aid

Many drugs and medicines can cause harm if taken incorrectly or misused. Many street drugs, such as methamphetamine or crack cocaine, have no known beneficial use in any amount.

Medicines that are used to treat a health problem can be misused, either accidentally or intentionally. This can occur when people take more than the normal dose or if the medicine is taken with alcohol or other medicines.

Drug interactions may also lead to side effects. So, it is important to let your health care provider know about all the medicines you are taking. This includes vitamins, supplements, medicines from other countries, and other medicines or drugs you bought without a prescription.

Many drugs and medicines are addictive. Sometimes, the addiction is gradual. And some drugs (such as cocaine and opioids) can cause addiction after only a few doses. Addiction means that a person has a strong urge to use the substance and can't stop, even if they want to.

Someone who has become addicted to a drug or medicine usually will have withdrawal symptoms when it is suddenly stopped. Treatment can help prevent or lessen withdrawal symptoms.

A drug or medicine dose that is large enough to cause harm to the body (toxic) is called an overdose. This may occur suddenly, when a large amount of the drug or medicine is taken at one time. It may also occur gradually as a drug or medicine builds up in the body over a longer period. Prompt medical attention may save the life of someone who has an overdose.

An overdose of narcotics (opioids) can cause sleepiness, slowed breathing, and even unconsciousness.

When prescription medicines are taken in higher than prescribed amounts, serious side effects may occur. Uppers (stimulants) produce excitement, increased heart rate, and rapid breathing. Downers (depressants) do the opposite.

Mind-altering drugs are called hallucinogens. They vary widely in effect and include drugs like peyote and LSD, which primarily affect serotonin receptors in the brain, as well as ketamine and PCP (angel dust), which affect multiple receptors in the brain. These mind-altering substances are not well understood and in some cases may cause paranoia, dangerous behaviors, or extreme social withdrawal.

Cannabis drugs such as marijuana may cause relaxation, impaired motor skills, and increased appetite.

Drug or medicine overdose symptoms vary widely, depending on the specific drug or medicine used, but may include:

• Abnormal pupil size or pupils that don't change size when light is shined into them
• Agitation
• Seizures
• Tremors
• Delusional or paranoid behavior, hallucinations
• Difficulty breathing
• Drowsiness, coma
• Nausea and vomiting
• Staggering or unsteady gait (ataxia)
• Sweating or extremely dry, hot skin, blisters, rash
• Violent or aggressive behavior
• Death

Drug or medicine withdrawal symptoms also vary widely, depending on the specific drug or medicine used, but may include:

• Abdominal cramping
• Agitation, restlessness
• Cold sweat
• Delusions, hallucinations
• Depression
• Nausea, vomiting, diarrhea
• Seizures
• Death

If someone has overdosed or has withdrawal symptoms, call 911 or the local emergency number right away. Then follow these steps:

• Check the person's airway, breathing, and pulse. If needed, begin CPR. If unconscious but breathing, carefully place the person in the recovery position by log rolling the person toward you onto their left side. Bend the top leg so both hip and knee are at right angles. Gently tilt their head back to keep the airway open. If the person is conscious, loosen the clothing and keep the person warm, and provide reassurance. Try to keep the person calm. If you suspect an overdose, try to prevent the person from taking more drugs. If the person is an opioid user, give naloxone if it's available.
• Treat the person for signs of shock. Signs include weakness, bluish lips and fingernails, clammy skin, paleness, and decreasing alertness.
• If the person is having seizures, give first aid for seizures.
• Keep monitoring the person's vital signs (pulse, rate of breathing, blood pressure, if possible) until emergency medical help arrives.
• If possible, try to determine which drug(s) were taken, how much and when. Save any pill bottles or other drug containers. Give this information to emergency personnel.

Things you shouldn't do when tending to someone who has overdosed:

• Do not put your own safety in danger. Some drugs can cause violent and unpredictable behavior. Call for medical help.
• Do not try to reason with someone who is on drugs. Do not expect them to behave reasonably.
• Do not offer your opinions when giving help. You don't need to know why the drugs were taken in order to give effective first aid.

Drug emergencies are not always easy to identify. If you think someone has overdosed, or if you think someone is having withdrawal, give first aid and seek medical help.

If you or someone you are with has overdosed, call the local emergency number (such as 911), or the local poison control center.

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at: Poisonhelp.org www.poisonhelp.org/help/. Just enter the product, poison, or medicine to get expert help.

Try to find out what drug or medicine the person has taken. If possible, collect all drug or medicine containers and any remaining drug or medicine samples or the person's vomit and take them to the hospital.

At the hospital, the provider will perform a history and physical exam. Tests and procedures will be done as necessary.

These may include:

• Activated charcoal and laxatives to help remove swallowed drugs from the body (sometimes given through a tube placed through the mouth into the stomach)
• Airway and breathing support, including oxygen, a face mask, tube through the mouth into the trachea, and connected to a breathing machine (ventilator)
• Blood and urine tests
• CT scan of the head, neck, and other areas
• Chest x-ray
• Electrocardiogram (ECG)
• Intravenous fluids (fluids through a vein)
• Medicines to reverse the effects of the drugs
• Mental health and social work evaluation and assistance

In serious cases, the person may need to be admitted to the hospital for further treatment.

The outcome depends on many things, including:

• The type and amount of drugs or medicines
• Where the drugs or medicines entered the body, such as through the mouth, nose, or by injection (intravenous or skin popping)
• Whether the person has other health problems

Many resources are available for treating substance use. Ask your provider about local resources.

Overdose from drugs; Drug abuse first aid; Alcohol misuse first aid

Barrett W, Iwanicki JL. THC and hallucinogens. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 145.

Meehan TJ. Care of the poisoned patient. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 135.

SAMHSA Substance Abuse and Mental Health Services Administration website. Opioid overdose prevention and reversal: how to recognize opioid overdose. www.samhsa.gov/substance-use/treatment/overdose-prevention. Updated December 22, 2025. Accessed May 20, 2026.

Weiss RD, Liebschutz JM. Drug use disorders. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 365.

Updated by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.