What is it?
Collagen peptides are used for aging skin and osteoarthritis. They are also used for osteoporosis, brittle nails, muscle strength, and many other conditions, but there is no good scientific evidence to support most of these uses.
Don't confuse collagen peptides with collagen type I (native), collagen type II (native), or gelatin.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for COLLAGEN PEPTIDES are as follows:
Possibly effective for...
- Aging skin. Taking collagen peptides by mouth seems to improve skin hydration and skin elasticity in older people. Taking collagen peptides might also lessen wrinkles, but this benefit is probably only modest.
- Osteoarthritis. Taking collagen peptides by mouth may slightly relieve pain and improve joint function in people with knee osteoarthritis. It may take about 3-5 months of daily treatment before benefit is seen.
Insufficient evidence to rate effectiveness for...
- Athletic performance. Early research shows that taking collagen peptides during intense training might help recreational athletes run longer when compared to the intense training alone.
- Eczema (atopic dermatitis). Early research shows that taking collagen peptides for 12 weeks might improve symptoms and severity of eczema. But not all collagen peptides seem to help.
- Burns. Early research shows that taking collagen peptides while in the hospital might help to speed up recovery from bad burns.
- Brittle nails. Early research shows that taking collagen peptides might improve brittle nails. It may increase nail growth and reduce broken nails.
- Cellulite. Early research shows that taking collagen peptides might help to reduce cellulite.
- Memory and thinking skills (cognitive function). Early research shows that taking collagen peptides might improve memory by a small amount.
- Diabetes. Early research shows that taking collagen peptides from fish might reduce blood sugar in people with diabetes.
- Muscle soreness caused by exercise. Early research shows that taking collagen peptides from cow hide before intense exercise doesn't seem to reduce muscle soreness.
- High blood pressure. Taking collagen peptides by mouth might lower blood pressure. But not all research agrees.
- Joint pain. Taking collagen peptides by mouth might reduce knee pain during exercise in younger athletes. It's unclear if collagen peptides reduce joint pain in older adults without osteoarthritis.
- Muscle strength. Early research shows that taking collagen peptides in addition to resistance exercise might improve hand-grip strength more than resistance exercise alone. But it doesn't seem to improve leg strength.
- Obesity. Early research shows that taking collagen peptides slightly reduces fat in overweight people.
- Low bone mass (osteopenia). Taking collagen peptides for 12 months might improve low bone mass in the spine and hip. But not all research agrees.
- Weak and brittle bones (osteoporosis). Early research suggests that taking collagen peptides does not improve bone mass.
- Pressure ulcers. Early research shows that taking collagen peptides might improve healing of pressure ulcers.
- Age-related muscle loss (sarcopenia). Early research shows that taking collagen peptides might improve strength in elderly males with age-related muscle loss.
- Sprains. Early research in athletes with past ankle sprains shows that taking collagen peptides might increase ankle stability. But it doesn't seem to improve ankle stiffness.
- Painful conditions caused by overuse of tendons (tendinopathy). Early research shows that taking collagen peptides in addition to exercise might improve tendinopathy of the Achilles tendon.
- Wound healing. Early research shows that taking collagen peptides might reduce skin redness and improve moisture and elasticity after laser-removal of skin.
- Skin wrinkles from sun damage. Some early research shows that collagen peptides might reduce wrinkles and improve skin moisture in women with skin wrinkles from sun damage.
- Dark skin patches on the face (melasma).
- Other conditions.
How does it work?
Are there safety concerns?
Special precautions & warnings:Pregnancy and breast-feeding: Not enough is known about the safety of collagen peptides when used in medicinal amounts during pregnancy and breastfeeding. Stay on the safe side and avoid use.
Are there interactions with medications?
- It is not known if this product interacts with any medicines.
Before taking this product, talk with your health professional if you take any medications.
Are there interactions with herbs and supplements?
- There are no known interactions with herbs and supplements.
Are there interactions with foods?
- There are no known interactions with foods.
What dose is used?
- For aging skin: Usually, 2.5-10 grams of collagen peptides have been taken by mouth daily for 8-12 weeks. Specific products that have shown some benefit in clinical research include Peptan-F or Peptan-P by Rousselot, Wellnex by Nitta Gelatin, VERISOL by Gelita AG, Nippi peptide FCP-EX by Nippi/Shizuoka, and Vinh Wellness Collagen by Vinh Hoan Corporation. Combination products containing collagen peptides and other ingredients that have shown some benefit include Gold Collagen Active by Minerva Research Labs and BioCell Collagen by BioCell Technology.
- For osteoarthritis: 10 grams of collagen peptides taken daily in one or two divided doses has been used for 3-5 months. A specific combination product containing collagen peptides and other ingredients (BioCell Collagen by BioCell Technology) has been used in a dose of 1 gram twice daily for up to 10 weeks.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.
- Moskowitz RW. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum. 2000;30:87-99. View abstract.
- Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-A pilot study. Int J Sport Nutr Exerc Metab. 2020:1-8. View abstract.
- Sangsuwan W, Asawanonda P. Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial. J Dermatolog Treat. 2020:1-6. View abstract.
- Lin P, Alexander RA, Liang CH, et al. Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial. J Cosmet Dermatol. 2021;20:188-194. View abstract.
- Oliviero F, Ramonda R, Hoxha A, et al. Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study. Reumatismo. 2020;72:125-130. View abstract.
- Argyrou C, Karlafti E, Lampropoulou-Adamidou K, et al. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia. J Musculoskelet Neuronal Interact. 2020;20:12-17.View abstract.
- Koizumi S, Inoue N, Sugihara F, Igase M. Effects of collagen hydrolysates on human brain structure and cognitive function: A pilot clinical study. Nutrients. 2019;12:50. View abstract.
- Bagheri Miyab K, Alipoor E, Vaghardoost R, et al. The effect of a hydrolyzed collagen-based supplement on wound healing in patients with burn: A randomized double-blind pilot clinical trial. Burns. 2020;46:156-163. View abstract.
- Jendricke P, Kohl J, Centner C, Gollhofer A, König D. Influence of specific collagen peptides and concurrent training on cardiometabolic parameters and performance indices in women: A randomized controlled trial. Front Nutr. 2020;7:580918. View abstract.
- Oikawa SY, Kamal MJ, Webb EK, McGlory C, Baker SK, Phillips SM. Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. Am J Clin Nutr. 2020;111:708-718. View abstract.
- Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20:825-834. View abstract.
- Zmitek K, Zmitek J, Rogl Butina M, Pogacnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Nutrients. 2020;12:618.View abstract.
- Zehra A, Burns J, Liu CK, et al. Cannabis Addiction and the Brain: a Review. J Neuroimmune Pharmacol. 2018;13:438-52. View abstract.
- Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27:113-9. View abstract.
- Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus. Appl Physiol Nutr Metab. 2010;35:797-804. View abstract.
- Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. Am J Med Sci. 2010;340:360-6. View abstract.
- Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114:1237-45. View abstract.
- Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y. Absorption and Urinary Excretion of Peptides after Collagen Tripeptide Ingestion in Humans. Biol Pharm Bull. 2016;39:428-34. View abstract.
- Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35:341-8. View abstract.
- Tak YJ, Kim YJ, Lee JG, et al. Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate (Raja Kenojei) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mar Drugs. 2019;17. pii: E157. View abstract.
- Sugihara F, Inoue N, Venkateswarathirukumara S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. Sci Rep. 2018;8:11403. View abstract.
- Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015;18:1340-8. View abstract.
- Saiga-Egusa A, Iwai K, Hayakawa T, Takahata Y, Morimatsu F. Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension. Biosci Biotechnol Biochem. 2009;73:422-4.
- Praet SFE, Purdam CR, Welvaert M, et al. Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients. Nutrients. 2019;11. pii: E76. View abstract.
- Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. Int J Sport Nutr Exerc Metab. 2019;29:526-531. View abstract.
- Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. Adv Skin Wound Care. 2006;19:92-6. View abstract.
- Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. J Sci Food Agric. 2015;95:702-7. View abstract.
- Kouguchi T, Ohmori T, Shimizu M, et al. Effects of a chicken collagen hydrolysate on the circulation system in subjects with mild hypertension or high-normal blood pressure. Biosci Biotechnol Biochem. 2013;77:691-6. View abstract.
- König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018;10. pii: E97. View abstract.
- Jendricke P, Centner C, Zdzieblik D, Gollhofer A, König D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients. 2019;11. pii: E892. View abstract.
- Ito N, Seki S, Ueda F. Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels-A Randomized, Double-Blind, Placebo-Controlled Trial. Mar Drugs. 2018;16. pii: E482. View abstract.
- Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017;16:520-526. View abstract.
- Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. J Dermatol Sci. 2017;88:357-364. View abstract.
- Elam ML, Johnson SA, Hooshmand S, et al. A calcium-collagen chelate dietary supplement attenuates bone loss in postmenopausal women with osteopenia: a randomized controlled trial. J Med Food. 2015;18:324-31. View abstract.
- Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. J Sports Sci Med. 2018;17:298-304. View abstract.
- Cúneo F, Costa-Paiva L, Pinto-Neto AM, Morais SS, Amaya-Farfan J. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Maturitas. 2010;65:253-7. View abstract.
- Clark KL, Sebastianelli W, Flechsenhar KR, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008;24:1485-96. View abstract.
- Choi SY, Kim WG, Ko EJ, et al. Effect of high advanced-collagen tripeptide on wound healing and skin recovery after fractional photothermolysis treatment. Clin Exp Dermatol. 2014;39:874-80. View abstract.
- Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015;14:291-301. View abstract.
- Alcock RD, Shaw GC, Tee N, Welvaert M, Burke LM. Urinary Hydroxyproline Is Only Suitable As a Biomarker for Acute Intake, Up to 6 hr Postingestion of Collagen Proteins in "Free-Living," Healthy, Active Males. Int J Sport Nutr Exerc Metab. 2019;29:461-465. View abstract.
- Sibilla S, Godfrey M, Brewer S, Budh-Raja A, Genovese L. An overview of the beneficial effects of hydrolysed collagen as a nutraceutical on skin properties: Scientific background and clinical studies. Open Neutraceut J. 2015;8:29-42.
- Czajka A, Kania EM, Genovese L, et al. Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res 2018;57:97-108.View abstract.
- Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10.View abstract.
- Shigemura Y, Iwasaki Y, Tateno M, et al. A pilot study for the detection of cyclic prolyl-hydroxyproline (Pro-Hyp) in human blood after ingestion of collagen hydrolysate. Nutrients 2018;10. pii: E1356. View abstract.
- Clifford T, Ventress M, Allerton DM, et al. The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. Amino Acids 2019;51:691-704. View abstract.
- De Luca C, Mikhal'chik EV, Suprun MV, et al. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev. 2016;2016:4389410. View abstract.
- Bruyère O, Zegels B, Leonori L, et al. Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study. Complement Ther Med. 2012 Jun;20:124-30. View abstract.
- Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN, et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr. 2009;60 Suppl 2:99-113. View abstract.
- Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016;96:4077-81. View abstract.
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017;42:588-595. View abstract.
- Lopez HL, Ziegenfuss TN, Park J. Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise. Integr Med (Encinitas). 2015;14:30-8. View abstract.
- Licensed Natural Health Products Database. Health Canada. http://webprod5.hc-sc.gc.ca/lnhpd-bdpsnh/info.do?licence=80034311&lang=eng. Updated February 27, 2014. Accessed January 15, 2015.
- Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Clin Interv Aging. 2012;7:267-273. View abstract.
- Schauss AG, Stenehjem J, Park J, Endres JR, Clewell A. Effect of the novel low molecular weight hydrolyzed chicken sternal cartilage extract, BioCell Collagen, on improving osteoarthritis-related symptoms: a randomized, double-blind, placebo-controlled trial. J Agric Food Chem. 2012;60:4096-4101. View abstract.
- Kalman DS, Schwartz HI, Pachon J, Sheldon E, Almada AL. A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis. FASEB Experimental Biology 2004 Abstracts, Washington DC, April 17-21, 2004; A90.
- Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. View abstract.