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Caléndula

¿Qué es?

La caléndula (Calendula officinalis) es una planta conocida como maravilla. No es lo mismo que las caléndulas ornamentales del género Tagetes cultivadas en huertos.

La caléndula es originaria de Asia y el sur de Europa y se ha utilizado tradicionalmente en los sistemas de medicina ayurvédica y Unani. Los químicos de la caléndula pueden ayudar a que crezca tejido nuevo en las heridas y a disminuir la hinchazón en la boca y la garganta.

La flor de caléndula se usa comúnmente para heridas, erupciones cutáneas, infecciones, inflamación y muchas otras condiciones. Pero no hay pruebas sólidas que respalden el uso de la caléndula para ningún propósito.

¿Qué tan efectivo es?

Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.

La clasificación de la eficacia para este producto es la siguiente:

¿Cómo funciona?

¿Hay preocupación por la seguridad de su uso?

Cuando se toma por vía oral: Las preparaciones de flor de caléndula probablemente sean seguras para la mayoría de las personas.

Cuando se aplica sobre la piel: Las preparaciones de flor de caléndula probablemente sean seguras para la mayoría de las personas.

Advertencias y precauciones especiales:

Embarazo: No tome caléndula por vía oral si está embarazada. Probablemente no sea seguro. Existe la preocupación de que pueda causar un aborto espontáneo. También es mejor evitar el uso tópico hasta que se sepa más.

Lactancia: No hay suficiente información confiable para saber si la caléndula es segura de usar durante la lactancia. Manténgase en el lado seguro y evite su uso.

Alergia a la ambrosía y plantas relacionadas: La caléndula puede causar una reacción alérgica en personas sensibles a la familia Asteraceae / Compositae. Los miembros de esta familia incluyen ambrosía, crisantemos, caléndulas, margaritas y muchos otros. Si tiene alergias, asegúrese de consultar con su proveedor de salud antes de tomar caléndula.

¿Existen interacciones con medicamentos?

Moderadas
Tenga cuidado con esta combinación
Medicamentos sedantes (depresores del SNC)
La caléndula puede causar somnolencia y respiración lenta. Algunos medicamentos, llamados sedantes, también pueden causar somnolencia y respiración lenta. Tomar caléndula con medicamentos sedantes puede causar problemas respiratorios y / o demasiada somnolencia.

¿Existen interacciones con hierbas y suplementos?

No se conoce ninguna interacción con hierbas y suplementos.

¿Existen interacciones con alimentos?

No se conoce ninguna interacción con alimentos.

¿Qué dosis se utiliza?

No hay suficiente información confiable para saber cuál podría ser una dosis adecuada de caléndula. Tenga en cuenta que los productos naturales no siempre son necesariamente seguros y las dosis pueden ser importantes. Asegúrese de seguir las instrucciones pertinentes en las etiquetas del producto y consulte a un profesional de la salud antes de usarlo.

Otros nombres

Calendula officinalis, Calendule, English Garden Marigold, Fleur de Calendule, Fleur de Tous les Mois, Garden Marigold, Gold-Bloom, Holligold, Marigold, Marybud, Pot Marigold, Souci des Champs, Souci des Jardins, Souci des Vignes, Souci Officinal, Zergul.

Metodología

Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

Referencias

  1. Final Assessment report on Calendula officinalis L., flos. European Medicines Agency: Committee on Herbal Medicinal Products (HMPC). 2018. EMA/HMPC/603409/2017. Available at: https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-calendula-officinalis-l-flos-revision-1_en.pdf.
  2. De Angelis C, Di Stadio A, Vitale S, et al. Use of calendula ointment after episiotomy: a randomized clinical trial. J Matern Fetal Neonatal Med. 2020:1-5. View abstract.
  3. Kirichenko TV, Sobenin IA, Markina YV, et al. Clinical effectiveness of a combination of black elder berries, violet herb, and calendula flowers in chronic obstructive pulmonary disease: the results of a double-blinded placebo-controlled study. Biology (Basel). 2020;9:83. doi: 10.3390/biology9040083. View abstract.
  4. Singh M, Bagewadi A. Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial. Int J Pharm Investig. 2017;7:88-93. View abstract.
  5. Morgia G, Russo GI, Urzì D, et al. A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III. Arch Ital Urol Androl. 2017;89:110-113. View abstract.
  6. Madisetti M, Kelechi TJ, Mueller M, Amella EJ, Prentice MA. Feasibility, acceptability, and tolerability of RGN107 in the palliative wound care management of chronic wound symptoms. J Wound Care. 2017;26(Sup1):S25-S34. View abstract.
  7. Marucci L, Farneti A, Di Ridolfi P, et al. Double-blind randomized phase III study comparing a mixture of natural agents versus placebo in the prevention of acute mucositis during chemoradiotherapy for head and neck cancer. Head Neck. 2017;39:1761-1769. View abstract.
  8. Tavassoli M, Shayeghi M, Abai M, et al. Repellency Effects of Essential Oils of Myrtle (Myrtus communis), Marigold (Calendula officinalis) Compared with DEET against Anopheles stephensi on Human Volunteers. Iran J Arthropod Borne Dis. 2011;5:10-22. View abstract.
  9. Sharp L, Finnilä K, Johansson H, et al. No differences between Calendula cream and aqueous cream in the prevention of acute radiation skin reactions--results from a randomised blinded trial. Eur J Oncol Nurs. 2013;17:429-35. View abstract.
  10. Saffari E, Mohammad-Alizadeh-Charandabi S, Adibpour M, et al. Comparing the Effects of Calendula Officinalis and Clotrimazole on Vaginal Candidiasis: A Randomized Controlled Trial. Women Health. 2016. View abstract.
  11. Re TA, Mooney D, Antignac E, et al. Application of the threshold of toxicological concern approach for the safety evaluation of calendulaflower (Calendula officinalis) petals and extracts used in cosmetic and personal care products. Food Chem Toxicol. 2009;47:1246-54. View abstract.
  12. Mahyari S, Mahyari B, Emami SA, et al. Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial. Complement Ther Clin Pract 2016;22:93-8. View abstract.
  13. Mahmoudi M, Adib-Hajbaghery M, Mashaiekhi M. Comparing the effects of Bentonite & Calendula on the improvement of infantile diaper dermatitis: A randomized controlled trial. Indian J Med Res. 2015;142:742-6. View abstract.
  14. Kodiyan J, Amber KT. A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions. Antioxidants (Basel). 2015;4:293-303. View abstract.
  15. Khairnar MS, Pawar B, Marawar PP, et al. Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent. J Indian Soc Periodontol. 2013;17:741-7. View abstract.
  16. Eghdampour F, Jahdie F, Kheyrkhah M, et al. The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial. J Caring Sci. 2013;2:279-86. View abstract.
  17. Buzzi M, Freitas Fd, Winter Mde B. Pressure ulcer healing with Plenusdermax Calendula officinalis L. extract. Rev Bras Enferm. 2016;69:250-7. View abstract.
  18. Buzzi M, de Freitas F, Winter M. A Prospective, Descriptive Study to Assess the Clinical Benefits of Using Calendula officinalis Hydroglycolic Extract for the Topical Treatment of Diabetic Foot Ulcers. Ostomy Wound Manage. 2016;62:8-24. View abstract.
  19. Arora D, Rani A, Sharma A. A review on phytochemistry and ethnopharmacological aspects of genus Calendula. Pharmacogn Rev. 2013;7:179-87. View abstract.
  20. Adib-Hajbaghery M, Mahmoudi M, Mashaiekhi M. The effects of Bentonite and Calendula on the improvement of infantile diaper dermatitis. J Res Med Sci. 2014;19:314-8. View abstract.
  21. Lievre M, Marichy J, Baux S, and et al. Controlled study of three ointments for the local management of 2nd and 3rd degree burns. Clin Trials Meta-analysis 1992;28:9-12.
  22. Neto, J. J., Fracasso, J. F., Neves, M. D. C. L. C., and et al. Treatment of varicose ulcer and skin lesions with calendula. Revista de Ciencias Farm Sao Paulo 1996;17:181-186.
  23. Shaparenko BA, Slivko AB, Bazarova OV, and et al. On use of medicinal plants for treatment of patients with chronic suppurative otitis. Zh Ushn Gorl Bolezn 1979;39:48-51.
  24. Sarrell EM, Mandelberg A, and Cohen HA. Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med 2001;155:796-799.
  25. Rao, SG, Udupa, AL, Udupa SL, and et al. Calendula and Hypericum: Two homeopathic drugs promoting wound healing in rats. Fitoterapia 1991;62:508-510.
  26. Della Loggia R. and et al. Topical anti-inflammatory activity of Calendula officinalis extracts. Planta Med 1990;56:658.
  27. Samochowiec L. Pharmacological study of saponosides from Aralia mandshurica Rupr. et Maxim and Calendula officinalis L. Herba Pol. 1983;29:151-155.
  28. Bojadjiev C. On the sedative and hypotensive effect of preparations from the plant Calendula officinalis. Nauch Trud Visshi Med Inst Sof 1964;43:15-20.
  29. Zitterl-Eglseer, K., Sosa, S., Jurenitsch, J., Schubert-Zsilavecz, M., Della, Loggia R., Tubaro, A., Bertoldi, M., and Franz, C. Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.). J Ethnopharmacol. 1997;57:139-144. View abstract.
  30. Della, Loggia R., Tubaro, A., Sosa, S., Becker, H., Saar, S., and Isaac, O. The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta Med 1994;60:516-520. View abstract.
  31. Klouchek-Popova, E., Popov, A., Pavlova, N., and Krusteva, S. Influence of the physiological regeneration and epithelialization using fractions isolated from Calendula officinalis. Acta Physiol Pharmacol Bulg. 1982;8:63-67. View abstract.
  32. de, Andrade M., Clapis, M. J., do Nascimento, T. G., Gozzo, Tde O., and de Almeida, A. M. Prevention of skin reactions due to teletherapy in women with breast cancer: a comprehensive review. Rev.Lat.Am.Enfermagem. 2012;20:604-611. View abstract.
  33. Naseer, S. and Lorenzo-Rivero, S. Role of Calendula extract in treatment of anal fissures. Am.Surg. 2012;78:E377-E378. View abstract.
  34. Kundakovic, T., Milenkovic, M., Zlatkovic, S., Nikolic, V., Nikolic, G., and Binic, I. Treatment of venous ulcers with the herbal-based ointment Herbadermal(R): a prospective non-randomized pilot study. Forsch.Komplementmed. 2012;19:26-30. View abstract.
  35. Tedeschi, C. and Benvenuti, C. Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study. Gynecol.Endocrinol. 2012;28:652-654. View abstract.
  36. Akhtar, N., Zaman, S. U., Khan, B. A., Amir, M. N., and Ebrahimzadeh, M. A. Calendula extract: effects on mechanical parameters of human skin. Acta Pol.Pharm. 2011;68:693-701. View abstract.
  37. McQuestion, M. Evidence-based skin care management in radiation therapy: clinical update. Semin.Oncol.Nurs. 2011;27:e1-17. View abstract.
  38. Machado, M. A., Contar, C. M., Brustolim, J. A., Candido, L., Azevedo-Alanis, L. R., Gregio, A. M., Trevilatto, P. C., and Soares de Lima, A. A. Management of two cases of desquamative gingivitis with clobetasol and Calendula officinalis gel. Biomed.Pap.Med.Fac.Univ Palacky.Olomouc.Czech.Repub. 2010;154:335-338. View abstract.
  39. Andersen, F. A., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Jr., Shank, R. C., Slaga, T. J., and Snyder, P. W. Final report of the Cosmetic Ingredient Review Expert Panel amended safety assessment of Calendula officinalis-derived cosmetic ingredients. Int.J.Toxicol. 2010;29(6 Suppl):221S-2243. View abstract.
  40. Kumar, S., Juresic, E., Barton, M., and Shafiq, J. Management of skin toxicity during radiation therapy: a review of the evidence. J.Med.Imaging Radiat.Oncol. 2010;54:264-279. View abstract.
  41. Tjeerdsma, F., Jonkman, M. F., and Spoo, J. R. Temporary arrest of basal cell carcinoma formation in a patient with basal cell naevus syndrome (BCNS) since treatment with a gel containing various plant extracts. J.Eur.Acad.Dermatol.Venereol. 2011;25:244-245. View abstract.
  42. Benomar, S., Boutayeb, S., Lalya, I., Errihani, H., Hassam, B., and El Gueddari, B. K. [Treatment and prevention of acute radiation dermatitis]. Cancer Radiother. 2010;14:213-216. View abstract.
  43. Chargari, C., Fromantin, I., and Kirova, Y. M. [Importance of local skin treatments during radiotherapy for prevention and treatment of radio-induced epithelitis]. Cancer Radiother. 2009;13:259-266. View abstract.
  44. Kassab, S., Cummings, M., Berkovitz, S., van, Haselen R., and Fisher, P. Homeopathic medicines for adverse effects of cancer treatments. Cochrane.Database.Syst.Rev. 2009;:CD004845. View abstract.
  45. Khalif, I. L., Quigley, E. M., Makarchuk, P. A., Golovenko, O. V., Podmarenkova, L. F., and Dzhanayev, Y. A. Interactions between symptoms and motor and visceral sensory responses of irritable bowel syndrome patients to spasmolytics (antispasmodics). J.Gastrointestin.Liver Dis. 2009;18:17-22. View abstract.
  46. Ukiya, M., Akihisa, T., Yasukawa, K., Tokuda, H., Suzuki, T., and Kimura, Y. Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers. J Nat Prod 2006;69:1692-1696. View abstract.
  47. Bashir, S., Janbaz, K. H., Jabeen, Q., and Gilani, A. H. Studies on spasmogenic and spasmolytic activities of Calendula officinalis flowers. Phytother Res 2006;20:906-910. View abstract.
  48. McQuestion, M. Evidence-based skin care management in radiation therapy. Semin.Oncol Nurs 2006;22:163-173. View abstract.
  49. Duran, V., Matic, M., Jovanovc, M., Mimica, N., Gajinov, Z., Poljacki, M., and Boza, P. Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int.J.Tissue React. 2005;27:101-106. View abstract.
  50. Pommier, P., Gomez, F., Sunyach, M. P., D'Hombres, A., Carrie, C., and Montbarbon, X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin.Oncol. 4-15-2004;22:1447-1453. View abstract.
  51. Neukirch, H., D'Ambrosio, M., Dalla, Via J., and Guerriero, A. Simultaneous quantitative determination of eight triterpenoid monoesters from flowers of 10 varieties of Calendula officinalis L. and characterisation of a new triterpenoid monoester. Phytochem.Anal. 2004;15:30-35. View abstract.
  52. Sarrell, E. M., Cohen, H. A., and Kahan, E. Naturopathic treatment for ear pain in children. Pediatrics 2003;111(5 Pt 1):e574-e579. View abstract.
  53. Marukami, T., Kishi, A., and Yoshikawa, M. Medicinal flowers. IV. Marigold. : Structures of new ionone and sesquiterpene glycosides from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001;49:974-978. View abstract.
  54. Yoshikawa, M., Murakami, T., Kishi, A., Kageura, T., and Matsuda, H. Medicinal flowers. III. Marigold. : hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis. Chem Pharm Bull (Tokyo) 2001;49:863-870. View abstract.
  55. Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13:7-12. View abstract.
  56. Cravotto, G., Boffa, L., Genzini, L., and Garella, D. Phytotherapeutics: an evaluation of the potential of 1000 plants. J Clin Pharm Ther 2010;35:11-48. View abstract.
  57. Reddy, K. K., Grossman, L., and Rogers, G. S. Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. J Am Acad Dermatol 2013;68:e127-e135. View abstract.
  58. Panahi Y, Sharif MR, Sharif A, et al. A randomized comparative trial on the therapeutic efficacy of topical aloe vera and Calendula officinalis on diaper dermatitis in children. ScientificWorldJournal. 2012;2012:810234. View abstract.
  59. Paulsen E. Contact sensitization from Compositae-containing herbal remedies and cosmetics. Contact Dermatitis 2002;47:189-98. View abstract.
  60. Kalvatchev Z, Walder R, Garzaro D. Anti-HIV activity of extracts from Calendula officinalis flowers. Biomed Pharmacother 1997;51:176-80. View abstract.
  61. Gol'dman II. [Anaphylactic shock after gargling with an infusion of Calendula]. Klin Med (Mosk) 1974;52:142-3. View abstract.
  62. Reider N, Komericki P, Hausen BM, et al. The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 2001;45:269-72.. View abstract.
  63. Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
  64. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  65. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  66. Tyler VE. Herbs of Choice. Binghamton, NY: Pharmaceutical Products Press, 1994.
  67. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
Documento revisado - 07/06/2021