Ácido fólico

Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.

La clasificación de la eficacia para este producto es la siguiente:

Eficaz para...

• Deficiencia de folato. La ingesta de ácido fólico mejora la deficiencia de folato.

Probablemente eficaz para...

• Niveles altos de homocisteína en sangre (hiperhomocisteinemia). Esta afección se ha relacionado con enfermedades cardíacas y accidentes cerebrovasculares. La ingesta de ácido fólico reduce los niveles de homocisteína en personas con niveles normales o altos de homocisteína y en personas con insuficiencia renal.
• Toxicidad provocada por el fármaco metotrexato. La ingesta de ácido fólico parece reducir las náuseas y los vómitos del tratamiento con metotrexato.
• Defectos congénitos del cerebro y la columna vertebral (defectos congénitos del tubo neural). El consumo de ácido fólico de 600 a 800 mcg por vía oral al día durante el embarazo reduce el riesgo de estos defectos de nacimiento. El ácido fólico puede provenir de la dieta o de los suplementos. Algunas personas que están en alto riesgo deben recibir 4000-5000 mcg al día.

Posiblemente eficaz para...

• Disminución de las habilidades de memoria y pensamiento en personas mayores. La ingesta de ácido fólico, con o sin otros suplementos, puede mejorar la memoria y las habilidades de pensamiento en las personas mayores que tienen una disminución mayor de lo esperado en las habilidades de pensamiento a esa edad. Pero no parece funcionar en personas mayores que experimentan la disminución habitual de las habilidades de pensamiento para su edad.
• Depresión. La ingesta de ácido fólico junto con antidepresivos parece mejorar los síntomas en algunas personas con depresión.
• Alta presión sanguínea. La ingesta diaria de ácido fólico durante al menos 6 semanas reduce la presión arterial en algunas personas con presión arterial alta que no están tomando otros medicamentos para la presión arterial.
• Agrandamiento de las encías causado por el fármaco fenitoína. La aplicación de ácido fólico en las encías parece prevenir este problema. Pero la ingesta de ácido fólico no parece ayudar.
• Accidente cerebrovascular. En áreas del mundo que no agregan ácido fólico a los productos de granos, tomar suplementos de ácido fólico puede reducir el riesgo de accidente cerebrovascular. Pero los suplementos no parecen ser útiles para las personas que viven en países que sí agregan ácido fólico a los productos a base de cereales.
• Un trastorno de la piel que provoca la aparición de manchas blancas en la piel (vitiligo). La ingesta de ácido fólico parece mejorar los síntomas de esta afección.

Posiblemente ineficaz para...

• Bajos niveles de glóbulos rojos sanos (anemia) debido a la deficiencia de hierro. Agregar ácido fólico a un suplemento de hierro no ayuda a tratar la anemia mejor que tomar un suplemento de hierro solo.
• Deterioro de las habilidades cognitivas y de la memoria que ocurren normalmente con la edad. La ingesta de ácido fólico no parece prevenir el deterioro de la función mental que ocurre normalmente con los adultos sanos que envejecen.
• Cataratas. La ingesta de ácido fólico con vitamina B6 y vitamina B12 no previene las cataratas. De hecho, podría aumentar la cantidad de cataratas que deben eliminarse.
• Diarrea. La ingesta de ácido fólico no parece prevenir la diarrea en los niños que están en riesgo de desnutrición. De hecho, incluso puede aumentar el riesgo de tener diarrea que dure más de unos pocos días.
• Prevención de caídas. La ingesta de ácido fólico con vitamina B12 no parece prevenir las caídas en las personas mayores que también toman vitamina D.
• Infertilidad masculina. La ingesta de ácido fólico, solo o con otros ingredientes, no parece mejorar la fertilidad masculina.
• Muerte de un bebé nonato o prematuro. La ingesta de ácido fólico durante el embarazo no parece reducir el riesgo de que un bebé muera justo antes o después del nacimiento. Pero ayuda a prevenir otros problemas de salud en el bebé.
• Cáncer de los glóbulos blancos (leucemia). La ingesta de ácido fólico durante el embarazo no reduce el riesgo de este tipo de cáncer en los niños.
• Huesos débiles y quebradizos (osteoporosis). En personas de edad avanzada con osteoporosis, la ingesta de ácido fólico con vitamina B12 y / o vitamina B6 no parece prevenir la fractura de huesos.
• Rendimiento físico en adultos mayores. La ingesta de ácido fólico con vitamina B12 no parece ayudar a las personas mayores a caminar mejor ni a tener manos más fuertes.
• Presión arterial alta durante el embarazo. Los suplementos de ácido fólico en dosis altas no parecen reducir la presión arterial durante el embarazo ni el riesgo de desarrollar una afección llamada preeclampsia.
• Infección de las vías respiratorias. La ingesta de ácido fólico no parece prevenir las infecciones pulmonares en los niños con riesgo de desnutrición.

Probablemente ineficaz para...

• Crecimientos no cancerosos en el intestino grueso y el recto (adenoma colorrectal). La ingesta de suplementos de ácido fólico no previene los crecimientos en el intestino grueso o el recto.
• Una condición hereditaria caracterizada por problemas de aprendizaje (síndrome del X frágil). La ingesta de ácido fólico no mejora los síntomas del síndrome de X frágil.
• Parto prematuro. La ingesta de ácido fólico durante el embarazo no disminuye el riesgo de tener un bebé prematuro. Pero ayuda a prevenir otros problemas de salud en el bebé.

Advertencias y precauciones especiales:

Moderadas

Tenga cuidado con esta combinación

5-Fluorouracilo

Existe cierta preocupación de que tomar grandes cantidades de ácido fólico con 5-fluorouracilo pueda aumentar algunos efectos secundarios del 5-fluorouracilo, especialmente los problemas estomacales. Hable con su proveedor de atención médica antes de tomar ácido fólico.

Capecitabina (Xeloda)

Existe cierta preocupación de que la ingesta de grandes cantidades de ácido fólico pueda aumentar los efectos secundarios de la capecitabina, especialmente los problemas estomacales como la diarrea y los vómitos. Hable con su proveedor de atención médica antes de tomar ácido fólico.

Fenitoína (Dilantin)

El cuerpo descompone la fenitoína para eliminarla. El ácido fólico podría aumentar la rapidez con que el cuerpo descompone la fenitoína. La ingesta de ácido fólico y fenitoína podría disminuir la eficacia de la fenitoína y aumentar la posibilidad de convulsiones.

Fenobarbital (Luminal)

El fenobarbital se usa para las convulsiones. La ingesta de ácido fólico puede disminuir la eficacia del fenobarbital para prevenir las convulsiones.

Fosfenitoína (Cerebyx)

La fosfenitoína se usa para las convulsiones. El cuerpo descompone la fosfenitoína para eliminarla. El ácido fólico puede aumentar la rapidez con que el cuerpo descompone la fosfenitoína. La ingesta de ácido fólico junto con fosfenitoína podría disminuir los efectos de la fosfenitoína para prevenir las convulsiones.

Pirimetamina (Daraprim)

La pirimetamina se usa para tratar infecciones parasitarias. El ácido fólico podría disminuir los efectos de la pirimetamina para el tratamiento de infecciones parasitarias.

Primidona (Mysoline)

La primidona se usa para las convulsiones. El ácido fólico puede provocar convulsiones en algunas personas. La ingesta de ácido fólico junto con primidona podría disminuir la eficacia de la primidona para prevenir las convulsiones.

Té verde

Existe cierta preocupación de que el extracto de té verde pueda evitar que el ácido fólico actúe como debería en el cuerpo. Esto podría provocar una afección similar a la deficiencia de ácido fólico.

Zinc

El ácido fólico puede interferir con la absorción de zinc. Pero las personas que obtienen suficiente zinc en su dieta no necesitan preocuparse por este efecto.

El ácido fólico se puede tomar con alimentos o sin alimentos.

Pero beber té verde podría reducir los niveles de ácido fólico en el cuerpo. Si tiene niveles bajos de ácido fólico, evite beber té verde.

Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

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197. Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., and Fielding, D. W. Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Arch.Dis.Child 1981;56:911-918. View abstract.
198. Blot, I., Papiernik, E., Kaltwasser, J. P., Werner, E., and Tchernia, G. Influence of routine administration of folic acid and iron during pregnancy. Gynecol.Obstet.Invest 1981;12:294-304. View abstract.
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203. Areekul, S., Subcharoen, A., Cheeramakara, C., Srisukawat, K., and Limsuwan, S. Studies on the effect of folic acid supplement on folate and vitamin B12 status in children. Southeast Asian J Trop.Med Public Health 1980;11:81-86. View abstract.
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205. Hunt, I. F., Murphy, N. J., Cleaver, A. E., Faraji, B., Swendseid, M. E., Coulson, A. H., Clark, V. A., Laine, N., Davis, C. A., and Smith, J. C., Jr. Zinc supplementation during pregnancy: zinc concentration of serum and hair from low-income women of Mexican descent. Am J Clin Nutr 1983;37:572-582. View abstract.
206. Laurence, K. M., James, N., Miller, M. H., Tennant, G. B., and Campbell, H. Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J (Clin Res Ed) 5-9-1981;282:1509-1511. View abstract.
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208. Brown, W. T., Jenkins, E. C., Friedman, E., Brooks, J., Cohen, I. L., Duncan, C., Hill, A. L., Malik, M. N., Morris, V., Wolf, E., and . Folic acid therapy in the fragile X syndrome. Am J Med Genet. 1984;17:289-297. View abstract.
209. Srisupandit, S., Pootrakul, P., Areekul, S., Neungton, S., Mokkaves, J., Kiriwat, O., and Kanokpongsukdi, S. A prophylactic supplementation of iron and folate in pregnancy. Southeast Asian J Trop Med Public Health 1983;14:317-323. View abstract.
210. Brattstrom, L. E., Hardebo, J. E., and Hultberg, B. L. Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke 1984;15:1012-1016. View abstract.
211. Seller, M. J. and Nevin, N. C. Periconceptional vitamin supplementation and the prevention of neural tube defects in south-east England and Northern Ireland. J Med Genet. 1984;21:325-330. View abstract.
212. Ek, J., Behncke, L., Halvorsen, K. S., and Magnus, E. Plasma and red cell folate values and folate requirements in formula-fed premature infants. Eur.J.Pediatr. 1984;142:78-82. View abstract.
213. Smithells, R. W., Nevin, N. C., Seller, M. J., Sheppard, S., Harris, R., Read, A. P., Fielding, D. W., Walker, S., Schorah, C. J., and Wild, J. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 5-7-1983;1:1027-1031. View abstract.
214. Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., and Fielding, D. W. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 2-16-1980;1:339-340. View abstract.
215. Asfour, R., Wahbeh, N., Waslien, C. I., Guindi, S., and Darby, W. J. Folacin requirement of children. III. Normal infants. Am.J.Clin Nutr. 1977;30:1098-1105. View abstract.
216. Fleming, A. F., Hendrickse, J. P., and Allan, N. C. The prevention of megaloblastic anaemia in pregnancy in Nigeria. J Obstet.Gynaecol.Br Commonw. 1968;75:425-432. View abstract.
217. Gandy, G. and Jacobson, W. Influence of folic acid on birthweight and growth of the erythroblastotic infant. III. Effect of folic acid supplementation. Arch.Dis.Child 1977;52:16-21. View abstract.
218. Osifo, B. O. The effect of folic acid and iron in the prevention of nutritional anaemias in pregnancy in Nigeria. Br J Nutr 1970;24:689-694. View abstract.
219. Baumslag, N., Edelstein, T., and Metz, J. Reduction of incidence of prematurity by folic acid supplementation in pregnancy. Br.Med.J. 1-3-1970;1:16-17. View abstract.
220. Iyengar, L. and Apte, S. V. Prophylaxis of anemia in pregnancy. Am.J Clin.Nutr 1970;23:725-730. View abstract.
221. Kral, V. A., Solyom, L., Enesco, H., and Ledwidge, B. Relationship of vitamin B12 and folic acid to memory function. Biol.Psychiatry 1970;2:19-26. View abstract.
222. Rolschau, J., Date, J., and Kristoffersen, K. Folic acid supplement and intrauterine growth. Acta Obstet.Gynecol.Scand. 1979;58:343-346. View abstract.
223. Matoth, Y., Zehavi, I., Topper, E., and Klein, T. Folate nutrition and growth in infancy. Arch.Dis.Child 1979;54:699-702. View abstract.
224. Shaw, D. M., Macsweeney, D. A., Johnson, A. L., O'Keeffe, R., Naidoo, D., Macleod, D. M., Jog, S., Preece, J. M., and Crowley, J. M. Folate and amine metabolites in senile dementia: a combined trial and biochemical study. Psychol.Med 1971;1:166-171. View abstract.
225. Burland, W. L., Simpson, K., and Lord, J. Response of low birthweight infant to treatment with folic acid. Arch.Dis.Child 1971;46:189-194. View abstract.
226. Fletcher, J., Gurr, A., Fellingham, F. R., Prankerd, T. A., Brant, H. A., and Menzies, D. N. The value of folic acid supplements in pregnancy. J Obstet.Gynaecol.Br Commonw. 1971;78:781-785. View abstract.
227. Iyengar, L. Folic acid requirements of Indian pregnant women. Am.J.Obstet.Gynecol. 1971;111:13-16. View abstract.
228. Roberts, P. M., Arrowsmith, D. E., Lloyd, A. V., and Monk-Jones, M. E. Effect of folic acid treatment on premature infants. Arch.Dis.Child 1972;47:631-634. View abstract.
229. Hall, M. H. Folic acid deficiency and abruptio placentae. J Obstet.Gynaecol.Br Commonw. 1972;79:222-225. View abstract.
230. Bowe, J. C., Cornish, E. J., and Dawson, M. Evaluation of folic acid supplements in children taking phenytoin. Dev.Med Child Neurol. 1971;13:343-354. View abstract.
231. Grant, R. H. and Stores, O. P. Folic acid in folate-deficient patients with epilepsy. Br Med J 12-12-1970;4:644-648. View abstract.
232. Jensen, O. N. and Olesen, O. V. Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates. Arch Neurol. 1970;22:181-182. View abstract.
233. Stevens, D., Burman, D., Strelling, M. K., and Morris, A. Folic acid supplementation in low birth weight infants. Pediatrics 1979;64:333-335. View abstract.
234. Samuel, P. D., Burland, W. L., and Simpson, K. Response to oral administration of pteroylmonoglutamic acid or pteroylpolyglutamate in newborn infants of low birth weight. Br.J.Nutr. 1973;30:165-169. View abstract.
235. Christiansen, C., Rodbro, P., and Lund, M. Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial. Br Med J 12-22-1973;4:695-701. View abstract.
236. Kendall, A. C., Jones, E. E., Wilson, C. I., Shinton, N. K., and Elwood, P. C. Folic acid in low birthweight infants. Arch.Dis.Child 1974;49:736-738. View abstract.
237. Mattson, R. H., Gallagher, B. B., Reynolds, E. H., and Glass, D. Folate therapy in epilepsy. A controlled study. Arch Neurol. 1973;29:78-81. View abstract.
238. Basu, R. N., Sood, S. K., Ramachandran, K., Mathur, M., and Ramalingaswami, V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Am.J Clin.Nutr 1973;26:591-594. View abstract.
239. Fleming, A. F., Martin, J. D., Hahnel, R., and Westlake, A. J. Effects of iron and folic acid antenatal supplements on maternal haematology and fetal wellbeing. Med.J.Aust. 9-21-1974;2:429-436. View abstract.
240. Ralston, A. J., Snaith, R. P., and Hinley, J. B. Effects of folic acid on fit-frequency and behaviour in epileptics on anticonvulsants. Lancet 4-25-1970;1:867-868. View abstract.
241. Horwitz, S. J., Klipstein, F. A., and Lovelace, R. E. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Lancet 3-16-1968;1:563-565. View abstract.
242. Harrison, K. A. Child-bearing, health and social priorities: a survey of 22 774 consecutive hospital births in Zaria, Northern Nigeria. Br J Obstet.Gynaecol. 1985;92 Suppl 5:1-119. View abstract.
243. Boers, G. H., Smals, A. G., Trijbels, F. J., Fowler, B., Bakkeren, J. A., Schoonderwaldt, H. C., Kleijer, W. J., and Kloppenborg, P. W. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N.Engl.J Med 9-19-1985;313:709-715. View abstract.
244. Fleming, A. F., Ghatoura, G. B., Harrison, K. A., Briggs, N. D., and Dunn, D. T. The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria. Ann Trop Med Parasitol. 1986;80:211-233. View abstract.
245. Madison, L. S., Wells, T. E., Fristo, T. E., and Benesch, C. G. A controlled study of folic acid treatment in three fragile X syndrome males. J Dev.Behav.Pediatr 1986;7:253-256. View abstract.
246. Froster-Iskenius, U., Bodeker, K., Oepen, T., Matthes, R., Piper, U., and Schwinger, E. Folic acid treatment in males and females with fragile-(X)-syndrome. Am J Med Genet. 1986;23(1-2):273-289. View abstract.
247. Spatling, L. and Spatling, G. Magnesium supplementation in pregnancy. A double-blind study. Br J Obstet.Gynaecol. 1988;95:120-125. View abstract.
248. Heimburger, D. C., Alexander, C. B., Birch, R., Butterworth, C. E., Jr., Bailey, W. C., and Krumdieck, C. L. Improvement in bronchial squamous metaplasia in smokers treated with folate and vitamin B12. Report of a preliminary randomized, double-blind intervention trial. JAMA 3-11-1988;259:1525-1530. View abstract.
249. Erlichman, C., Fine, S., Wong, A., and Elhakim, T. A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol. 1988;6:469-475. View abstract.
250. Mardones-Santander, F., Rosso, P., Stekel, A., Ahumada, E., Llaguno, S., Pizarro, F., Salinas, J., Vial, I., and Walter, T. Effect of a milk-based food supplement on maternal nutritional status and fetal growth in underweight Chilean women. Am J Clin Nutr 1988;47:413-419. View abstract.
251. Peto, R., Gray, R., Collins, R., Wheatley, K., Hennekens, C., Jamrozik, K., Warlow, C., Hafner, B., Thompson, E., Norton, S., and . Randomised trial of prophylactic daily aspirin in British male doctors. Br Med J (Clin Res Ed) 1-30-1988;296:313-316. View abstract.
252. Hagerman, R. J., Murphy, M. A., and Wittenberger, M. D. A controlled trial of stimulant medication in children with the fragile X syndrome. Am J Med Genet. 1988;30(1-2):377-392. View abstract.
253. Hanrahan, P. S. and Russell, A. S. Concurrent use of folinic acid and methotrexate in rheumatoid arthritis. J Rheumatol 1988;15:1078-1080. View abstract.
254. Charoenlarp, P., Dhanamitta, S., Kaewvichit, R., Silprasert, A., Suwanaradd, C., Na-Nakorn, S., Prawatmuang, P., Vatanavicharn, S., Nutcharas, U., Pootrakul, P., and . A WHO collaborative study on iron supplementation in Burma and in Thailand. Am.J.Clin.Nutr. 1988;47:280-297. View abstract.
255. Coppen, A., Chaudhry, S., and Swade, C. Folic acid enhances lithium prophylaxis. J.Affect.Disord. 1986;10:9-13. View abstract.
256. Backman, N., Holm, A. K., Hanstrom, L., Blomquist, H. K., Heijbel, J., and Safstrom, G. Folate treatment of diphenylhydantoin-induced gingival hyperplasia. Scand J Dent Res 1989;97:222-232. View abstract.
257. Lira, P., Barrena, N., Foradori, A., Gormaz, G., and Grebe, G. [Deficiency of folates in pregnancy: effect of supplementary folic acid]. Sangre (Barc.) 1989;34:24-27. View abstract.
258. Foged, N., Lillquist, K., Rolschau, J., and Blaabjerg, O. Effect of folic acid supplementation on small-for-gestational-age infants born at term. Eur.J.Pediatr. 1989;149:65-67. View abstract.
259. Sibai, B. M., Villar, M. A., and Bray, E. Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial. Am J Obstet.Gynecol. 1989;161:115-119. View abstract.
260. Araki, A., Sako, Y., Fukushima, Y., Matsumoto, M., Asada, T., and Kita, T. Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects. Atherosclerosis 1989;79(2-3):139-146. View abstract.
261. Mahomed, K., James, D. K., Golding, J., and McCabe, R. Zinc supplementation during pregnancy: a double blind randomised controlled trial. BMJ 9-30-1989;299:826-830. View abstract.
262. Milunsky, A., Jick, H., Jick, S. S., Bruell, C. L., MacLaughlin, D. S., Rothman, K. J., and Willett, W. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 11-24-1989;262:2847-2852. View abstract.
263. Fuller, N. J., Bates, C. J., Hayes, R. J., Bradley, A. K., Greenwood, A. M., Tulloch, S., and Greenwood, B. M. The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Ann.Trop.Paediatr. 1988;8:61-67. View abstract.
264. Brattstrom, L., Israelsson, B., Norrving, B., Bergqvist, D., Thorne, J., Hultberg, B., and Hamfelt, A. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 1990;81:51-60. View abstract.
265. Vergel, R. G., Sanchez, L. R., Heredero, B. L., Rodriguez, P. L., and Martinez, A. J. Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat.Diagn. 1990;10:149-152. View abstract.
266. Coull, B. M., Malinow, M. R., Beamer, N., Sexton, G., Nordt, F., and de, Garmo P. Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke. Stroke 1990;21:572-576. View abstract.
267. Pena-Rosas, J. P., De-Regil, L. M., Dowswell, T., and Viteri, F. E. Daily oral iron supplementation during pregnancy. Cochrane.Database.Syst.Rev. 2012;12:CD004736. View abstract.
268. Haider, B. A. and Bhutta, Z. A. Multiple-micronutrient supplementation for women during pregnancy. Cochrane.Database.Syst.Rev. 2012;11:CD004905. View abstract.
269. Chuang, V. T. and Suno, M. Levoleucovorin as replacement for leucovorin in cancer treatment. Ann.Pharmacother. 2012;46:1349-1357. View abstract.
270. Fekete, K., Berti, C., Trovato, M., Lohner, S., Dullemeijer, C., Souverein, O. W., Cetin, I., and Decsi, T. Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr.J. 2012;11:75. View abstract.
271. Xu, F., Zhao, X., Zeng, S. M., Li, L., Zhong, H. B., and Li, M. Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis. Ophthalmology 2012;119:2493-2499. View abstract.
272. Vargas, A. J. and Thompson, P. A. Diet and nutrient factors in colorectal cancer risk. Nutr.Clin Pract. 2012;27:613-623. View abstract.
273. Yang, H. T., Lee, M., Hong, K. S., Ovbiagele, B., and Saver, J. L. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur.J.Intern.Med. 2012;23:745-754. View abstract.
274. Morse, N. L. Benefits of docosahexaenoic acid, folic acid, vitamin D and iodine on foetal and infant brain development and function following maternal supplementation during pregnancy and lactation. Nutrients. 2012;4:799-840. View abstract.
275. Skorka, A., Gieruszczak-Bialek, D., Piescik, M., and Szajewska, H. Effects of prenatal and/or postnatal (maternal and/or child) folic acid supplementation on the mental performance of children. Crit Rev.Food Sci.Nutr. 2012;52:959-964. View abstract.
276. Papakostas, G. I., Cassiello, C. F., and Iovieno, N. Folates and S-adenosylmethionine for major depressive disorder. Can.J.Psychiatry 2012;57:406-413. View abstract.
277. Zhou, K., Zhao, R., Geng, Z., Jiang, L., Cao, Y., Xu, D., Liu, Y., Huang, L., and Zhou, J. Association between B-group vitamins and venous thrombosis: systematic review and meta-analysis of epidemiological studies. J.Thromb.Thrombolysis. 2012;34:459-467. View abstract.
278. Ramakrishnan, U., Grant, F., Goldenberg, T., Zongrone, A., and Martorell, R. Effect of women's nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:285-301. View abstract.
279. Ramakrishnan, U., Grant, F. K., Goldenberg, T., Bui, V., Imdad, A., and Bhutta, Z. A. Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: a systematic review. Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:153-167. View abstract.
280. Bhutta, Z. A., Imdad, A., Ramakrishnan, U., and Martorell, R. Is it time to replace iron folate supplements in pregnancy with multiple micronutrients? Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:27-35. View abstract.
281. Castillo, L., Tur, J. A., and Uauy, R. [Folate and breast cancer risk: a systematic review]. Rev.Med.Chil. 2012;140:251-260. View abstract.
282. Sudchada, P., Saokaew, S., Sridetch, S., Incampa, S., Jaiyen, S., and Khaithong, W. Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2012;98:151-158. View abstract.
283. Jardine, M. J., Kang, A., Zoungas, S., Navaneethan, S. D., Ninomiya, T., Nigwekar, S. U., Gallagher, M. P., Cass, A., Strippoli, G., and Perkovic, V. The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ 2012;344:e3533. View abstract.
284. Wu, C. C., Zheng, C. M., Lin, Y. F., Lo, L., Liao, M. T., and Lu, K. C. Role of homocysteine in end-stage renal disease. Clin Biochem. 2012;45(16-17):1286-1294. View abstract.
285. Huo, Y., Qin, X., Wang, J., Sun, N., Zeng, Q., Xu, X., Liu, L., Xu, X., and Wang, X. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int.J.Clin Pract. 2012;66:544-551. View abstract.
286. Lohner, S., Fekete, K., Berti, C., Hermoso, M., Cetin, I., Koletzko, B., and Decsi, T. Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review. Int.J.Food Sci.Nutr. 2012;63:1014-1020. View abstract.
287. Castillo, Lancellotti C., Tur Mari, J. A., and Uauy, Dagach R. [Effect of folate and related nutrients on cognitive function in older people; systematic review]. Nutr.Hosp. 2012;27:90-102. View abstract.
288. Castillo-Lancellotti, C., Tur Mari, J. A., and Uauy, Dagach R. [Folic acid supplementation and colorrectal adenoma recurrence: systematic review]. Nutr.Hosp. 2012;27:13-21. View abstract.
289. Mayne, S. T., Ferrucci, L. M., and Cartmel, B. Lessons learned from randomized clinical trials of micronutrient supplementation for cancer prevention. Annu.Rev.Nutr. 8-21-2012;32:369-390. View abstract.
290. Perez, L., Heim, L., Sherzai, A., Jaceldo-Siegl, K., and Sherzai, A. Nutrition and vascular dementia. J.Nutr.Health Aging 2012;16:319-324. View abstract.
291. Clarke, R., Bennett, D. A., Parish, S., Verhoef, P., Dotsch-Klerk, M., Lathrop, M., Xu, P., Nordestgaard, B. G., Holm, H., Hopewell, J. C., Saleheen, D., Tanaka, T., Anand, S. S., Chambers, J. C., Kleber, M. E., Ouwehand, W. H., Yamada, Y., Elbers, C., Peters, B., Stewart, A. F., Reilly, M. M., Thorand, B., Yusuf, S., Engert, J. C., Assimes, T. L., Kooner, J., Danesh, J., Watkins, H., Samani, N. J., Collins, R., and Peto, R. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS.Med. 2012;9:e1001177. View abstract.
292. Marik, P. E. and Flemmer, M. Do dietary supplements have beneficial health effects in industrialized nations: what is the evidence? JPEN J.Parenter.Enteral Nutr. 2012;36:159-168. View abstract.
293. Lin, R. J., Krall, R., Westerberg, B. D., Chadha, N. K., and Chau, J. K. Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. Laryngoscope 2012;122:624-635. View abstract.
294. Pan, Y., Guo, L. L., Cai, L. L., Zhu, X. J., Shu, J. L., Liu, X. L., and Jin, H. M. Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: a meta-analysis of randomised, controlled trials. Br.J.Nutr. 2012;108:400-407. View abstract.
295. Ford, A. H. and Almeida, O. P. Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials. J.Alzheimers.Dis. 2012;29:133-149. View abstract.
296. Qin, X., Xu, M., Zhang, Y., Li, J., Xu, X., Wang, X., Xu, X., and Huo, Y. Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials. Atherosclerosis 2012;222:307-313. View abstract.
297. Zhao, Z., Pelletier, E., Barber, B., Bhosle, M., Wang, S., Gao, S., and Klingman, D. Patterns of treatment with chemotherapy and monoclonal antibodies for metastatic colorectal cancer in Western Europe. Curr Med.Res Opin. 2012;28:221-229. View abstract.
298. Fruzzetti, F. Beyaz(R): an oral contraceptive fortified with folate. Womens Health (Lond Engl.) 2012;8:13-19. View abstract.
299. Xu, F., Zhang, L., and Li, M. Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis. Graefes Arch.Clin Exp.Ophthalmol. 2012;250:1067-1074. View abstract.
300. Czeizel, A. E. Periconceptional folic acid-containing multivitamin supplementation for the prevention of neural tube defects and cardiovascular malformations. Ann.Nutr.Metab 2011;59:38-40. View abstract.
301. Solimando, R., Bazzoli, F., and Ricciardiello, L. Chemoprevention of colorectal cancer: a role for ursodeoxycholic acid, folate and hormone replacement treatment? Best.Pract.Res Clin Gastroenterol. 2011;25(4-5):555-568. View abstract.
302. Vieitez, J. M., Garcia-Carbonero, R., Aparicio, J., Feliu, J., Gonzalez-Flores, E., Grande, E., Perez-Hoyos, T., Salud, A., Torres, E., Valero, M., Valladares-Ayerbes, M., and Diaz-Rubio, E. Recommendations and expert opinion on the adjuvant treatment of colon cancer in Spain. Clin Transl.Oncol. 2011;13:798-804. View abstract.
303. Morris, M. C. Nutritional determinants of cognitive aging and dementia. Proc.Nutr.Soc. 2012;71:1-13. View abstract.
304. Bao, Y., Michaud, D. S., Spiegelman, D., Albanes, D., Anderson, K. E., Bernstein, L., van den Brandt, P. A., English, D. R., Freudenheim, J. L., Fuchs, C. S., Giles, G. G., Giovannucci, E., Goldbohm, R. A., Hakansson, N., Horn-Ross, P. L., Jacobs, E. J., Kitahara, C. M., Marshall, J. R., Miller, A. B., Robien, K., Rohan, T. E., Schatzkin, A., Stevens, V. L., Stolzenberg-Solomon, R. Z., Virtamo, J., Wolk, A., Ziegler, R. G., and Smith-Warner, S. A. Folate intake and risk of pancreatic cancer: pooled analysis of prospective cohort studies. J.Natl.Cancer Inst. 12-21-2011;103:1840-1850. View abstract.
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408. Ma, E., Iwasaki, M., Junko, I., Hamada, G. S., Nishimoto, I. N., Carvalho, S. M., Motola, J., Jr., Laginha, F. M., and Tsugane, S. Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women. BMC.Cancer 2009;9:122. View abstract.
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412. Ericson, U., Sonestedt, E., Ivarsson, M. I., Gullberg, B., Carlson, J., Olsson, H., and Wirfalt, E. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmo Diet and Cancer cohort. Cancer Epidemiol.Biomarkers Prev. 2009;18:1101-1110. View abstract.
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415. Ntaios, G., Savopoulos, C., Karamitsos, D., Economou, I., Destanis, E., Chryssogonidis, I., Pidonia, I., Zebekakis, P., Polatides, C., Sion, M., Grekas, D., and Hatzitolios, A. The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial. Int.J.Cardiol. 8-6-2010;143:16-19. View abstract.
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424. Larsson, S. C., Bergkvist, L., and Wolk, A. Folate intake and risk of breast cancer by estrogen and progesterone receptor status in a Swedish cohort. Cancer Epidemiol.Biomarkers Prev. 2008;17:3444-3449. View abstract.
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427. Haberg, S. E., London, S. J., Stigum, H., Nafstad, P., and Nystad, W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis.Child 2009;94:180-184. View abstract.
428. Kalmbach, R. D., Choumenkovitch, S. F., Troen, A. P., Jacques, P. F., D'Agostino, R., and Selhub, J. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr 2008;138:2323-2327. View abstract.
429. Zhang, S. M., Cook, N. R., Albert, C. M., Gaziano, J. M., Buring, J. E., and Manson, J. E. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA 11-5-2008;300:2012-2021. View abstract.
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431. Prey, S. and Paul, C. Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review. Br J Dermatol. 2009;160:622-628. View abstract.
432. Aisen, P. S., Schneider, L. S., Sano, M., Diaz-Arrastia, R., van Dyck, C. H., Weiner, M. F., Bottiglieri, T., Jin, S., Stokes, K. T., Thomas, R. G., and Thal, L. J. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 10-15-2008;300:1774-1783. View abstract.
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434. Figueiredo, J. C., Levine, A. J., Grau, M. V., Barry, E. L., Ueland, P. M., Ahnen, D. J., Byers, T., Bresalier, R. S., Summers, R. W., Bond, J., McKeown-Eyssen, G. E., Sandler, R. S., Haile, R. W., and Baron, J. A. Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels. Cancer Epidemiol.Biomarkers Prev. 2008;17:2625-2631. View abstract.
435. Kendrick, J. and Chonchol, M. B. Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease. Nat.Clin Pract.Nephrol. 2008;4:672-681. View abstract.
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437. Duffy, C. M., Assaf, A., Cyr, M., Burkholder, G., Coccio, E., Rohan, T., McTiernan, A., Paskett, E., Lane, D., and Chetty, V. K. Alcohol and folate intake and breast cancer risk in the WHI Observational Study. Breast Cancer Res Treat. 2009;116:551-562. View abstract.
438. Levine, A. J., Wallace, K., Tsang, S., Haile, R. W., Saibil, F., Ahnen, D., Cole, B. F., Barry, E. L., Munroe, D. J., Ali, I. U., Ueland, P., and Baron, J. A. MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. Cancer Epidemiol.Biomarkers Prev. 2008;17:2409-2415. View abstract.
439. Ebbing, M., Bleie, O., Ueland, P. M., Nordrehaug, J. E., Nilsen, D. W., Vollset, S. E., Refsum, H., Pedersen, E. K., and Nygard, O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 8-20-2008;300:795-804. View abstract.
440. Strozzi, G. P. and Mogna, L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol 2008;42 Suppl 3 Pt 2:S179-S184. View abstract.
441. Jaszewski, R., Misra, S., Tobi, M., Ullah, N., Naumoff, J. A., Kucuk, O., Levi, E., Axelrod, B. N., Patel, B. B., and Majumdar, A. P. Folic acid supplementation inhibits recurrence of colorectal adenomas: a randomized chemoprevention trial. World J Gastroenterol 7-28-2008;14:4492-4498. View abstract.
442. Hadler, M. C., Sigulem, D. M., Alves, Mde F., and Torres, V. M. Treatment and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiania, Goias State, Brazil: a randomized controlled trial. Cad.Saude Publica 2008;24 Suppl 2:S259-S271. View abstract.
443. Kabat, G. C., Miller, A. B., Jain, M., and Rohan, T. E. Dietary intake of selected B vitamins in relation to risk of major cancers in women. Br.J.Cancer 9-2-2008;99:816-821. View abstract.
444. Mao, G., Hong, X., Xing, H., Liu, P., Liu, H., Yu, Y., Zhang, S., Jiang, S., Wang, X., and Xu, X. Efficacy of folic acid and enalapril combined therapy on reduction of blood pressure and plasma glucose: a multicenter, randomized, double-blind, parallel-controlled, clinical trial. Nutrition 2008;24(11-12):1088-1096. View abstract.
445. Fioravanti, M., Ferrario, E., Massaia, M., Cappa, G., Rivolta, G., Grossi, E., and Buckley, A. E. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch.Gerontol.Geriatr. 1998;26:1-13. View abstract.
446. Chen, G., Song, X., Ji, Y., Zhang, L., Pei, L., Chen, J., Liu, J., Li, C., and Zheng, X. Prevention of NTDs with periconceptional multivitamin supplementation containing folic acid in China. Birth Defects Res A Clin Mol.Teratol. 2008;82:592-596. View abstract.
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448. Johnson, C. Y. and Little, J. Folate intake, markers of folate status and oral clefts: is the evidence converging? Int J Epidemiol. 2008;37:1041-1058. View abstract.
449. Ford, A. H., Flicker, L., Thomas, J., Norman, P., Jamrozik, K., and Almeida, O. P. Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial. J Clin.Psychiatry 2008;69:1203-1209. View abstract.
450. Kile, M. L. and Ronnenberg, A. G. Can folate intake reduce arsenic toxicity? Nutr Rev 2008;66:349-353. View abstract.
451. Szczurko, O. and Boon, H. S. A systematic review of natural health product treatment for vitiligo. BMC.Dermatol. 2008;8:2. View abstract.
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454. Kaisar, M. O., Isbel, N. M., and Johnson, D. W. Recent clinical trials of pharmacologic cardiovascular interventions in patients with chronic kidney disease. Rev Recent Clin Trials 2008;3:79-88. View abstract.
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456. Stockley, L. and Lund, V. Use of folic acid supplements, particularly by low-income and young women: a series of systematic reviews to inform public health policy in the UK. Public Health Nutr 2008;11:807-821. View abstract.
457. Potena, L., Grigioni, F., Masetti, M., Magnani, G., Coccolo, F., Fallani, F., Russo, A., Pizzuti, M., Scalone, A., Bianchi, I. G., and Branzi, A. Long-term effect of folic acid therapy in heart transplant recipients: follow-up analysis of a randomized study. Transplantation 4-27-2008;85:1146-1150. View abstract.
458. McNulty, H., Pentieva, K., Hoey, L., and Ward, M. Homocysteine, B-vitamins and CVD. Proc.Nutr Soc. 2008;67:232-237. View abstract.
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460. Sayed, A. R., Bourne, D., Pattinson, R., Nixon, J., and Henderson, B. Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. Birth Defects Res A Clin Mol.Teratol. 2008;82:211-216. View abstract.
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462. Ellis, J. M., Tan, H. K., Gilbert, R. E., Muller, D. P., Henley, W., Moy, R., Pumphrey, R., Ani, C., Davies, S., Edwards, V., Green, H., Salt, A., and Logan, S. Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial. BMJ 3-15-2008;336:594-597. View abstract.
463. Torrioli, M. G., Vernacotola, S., Peruzzi, L., Tabolacci, E., Mila, M., Militerni, R., Musumeci, S., Ramos, F. J., Frontera, M., Sorge, G., Marzullo, E., Romeo, G., Vallee, L., Veneselli, E., Cocchi, E., Garbarino, E., Moscato, U., Chiurazzi, P., D'Iddio, S., Calvani, M., and Neri, G. A double-blind, parallel, multicenter comparison of L-acetylcarnitine with placebo on the attention deficit hyperactivity disorder in fragile X syndrome boys. Am.J Med.Genet.A 4-1-2008;146:803-812. View abstract.
464. Clarke, R. B-vitamins and prevention of dementia. Proc Nutr Soc 2008;67:75-81. View abstract.
465. Suzuki, T., Matsuo, K., Hirose, K., Hiraki, A., Kawase, T., Watanabe, M., Yamashita, T., Iwata, H., and Tajima, K. One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 2008;29:356-362. View abstract.
466. Logan, R. F., Grainge, M. J., Shepherd, V. C., Armitage, N. C., and Muir, K. R. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 2008;134:29-38. View abstract.
467. Mann, J. F., Sheridan, P., McQueen, M. J., Held, C., Arnold, J. M., Fodor, G., Yusuf, S., and Lonn, E. M. Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease--results of the renal Hope-2 study. Nephrol.Dial.Transplant. 2008;23:645-653. View abstract.
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470. Zintzaras, E. Maternal gene polymorphisms involved in folate metabolism and risk of Down syndrome offspring: a meta-analysis. J Hum Genet. 2007;52:943-953. View abstract.
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474. de, Bree A., van Mierlo, L. A., and Draijer, R. Folic acid improves vascular reactivity in humans: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2007;86:610-617. View abstract.
475. Ericson, U., Sonestedt, E., Gullberg, B., Olsson, H., and Wirfalt, E. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. Am.J.Clin Nutr. 2007;86:434-443. View abstract.
476. Joyce, D. A., Will, R. K., Hoffman, D. M., Laing, B., and Blackbourn, S. J. Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid. Ann.Rheum.Dis. 1991;50:913-914. View abstract.
477. De, Wals P., Tairou, F., Van Allen, M. I., Uh, S. H., Lowry, R. B., Sibbald, B., Evans, J. A., Van den Hof, M. C., Zimmer, P., Crowley, M., Fernandez, B., Lee, N. S., and Niyonsenga, T. Reduction in neural-tube defects after folic acid fortification in Canada. N.Engl.J Med 7-12-2007;357:135-142. View abstract.
478. Dockerty, J. D., Herbison, P., Skegg, D. C., and Elwood, M. Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: a case-control study. BMC.Public Health 2007;7:136. View abstract.
479. Connelly, P. J., Prentice, N. P., Cousland, G., and Bonham, J. A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. Int J Geriatr Psychiatry 2008;23:155-160. View abstract.
480. Nanayakkara, P. W., van, Guldener C., ter Wee, P. M., Scheffer, P. G., van Ittersum, F. J., Twisk, J. W., Teerlink, T., van, Dorp W., and Stehouwer, C. D. Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study. Arch.Intern.Med. 6-25-2007;167:1262-1270. View abstract.
481. Raman, G., Tatsioni, A., Chung, M., Rosenberg, I. H., Lau, J., Lichtenstein, A. H., and Balk, E. M. Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function. J Nutr 2007;137:1789-1794. View abstract.
482. Gilbody, S., Lightfoot, T., and Sheldon, T. Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol.Community Health 2007;61:631-637. View abstract.
483. Cole, B. F., Baron, J. A., Sandler, R. S., Haile, R. W., Ahnen, D. J., Bresalier, R. S., McKeown-Eyssen, G., Summers, R. W., Rothstein, R. I., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Robertson, D. J., Beck, G. J., Bond, J. H., Byers, T., Mandel, J. S., Mott, L. A., Pearson, L. H., Barry, E. L., Rees, J. R., Marcon, N., Saibil, F., Ueland, P. M., and Greenberg, E. R. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 6-6-2007;297:2351-2359. View abstract.
484. Wang, X., Qin, X., Demirtas, H., Li, J., Mao, G., Huo, Y., Sun, N., Liu, L., and Xu, X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 6-2-2007;369:1876-1882. View abstract.
485. Pena, A. S., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., and Couper, J. Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care 2007;30:2122-2127. View abstract.
486. McNeill, G., Avenell, A., Campbell, M. K., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., and Vale, L. D. Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial. Nutr J 2007;6:10. View abstract.
487. Ray, J. G., Kearon, C., Yi, Q., Sheridan, P., and Lonn, E. Homocysteine-lowering therapy and risk for venous thromboembolism: a randomized trial. Ann.Intern.Med. 6-5-2007;146:761-767. View abstract.
488. Shirodaria, C., Antoniades, C., Lee, J., Jackson, C. E., Robson, M. D., Francis, J. M., Moat, S. J., Ratnatunga, C., Pillai, R., Refsum, H., Neubauer, S., and Channon, K. M. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 5-1-2007;115:2262-2270. View abstract.
489. Vianna, A. C., Mocelin, A. J., Matsuo, T., Morais-Filho, D., Largura, A., Delfino, V. A., Soares, A. E., and Matni, A. M. Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events. Hemodial.Int 2007;11:210-216. View abstract.
490. Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of pediatric cancers: a meta-analysis. Clin Pharmacol.Ther 2007;81:685-691. View abstract.
491. Moens, A. L., Claeys, M. J., Wuyts, F. L., Goovaerts, I., Van, Hertbruggen E., Wendelen, L. C., Van Hoof, V. O., and Vrints, C. J. Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol 2-15-2007;99:476-481. View abstract.
492. Haan, M. N., Miller, J. W., Aiello, A. E., Whitmer, R. A., Jagust, W. J., Mungas, D. M., Allen, L. H., and Green, R. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2007;85:511-517. View abstract.
493. Winkels, R. M., Brouwer, I. A., Siebelink, E., Katan, M. B., and Verhoef, P. Bioavailability of food folates is 80% of that of folic acid. Am J Clin Nutr 2007;85:465-473. View abstract.
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495. Larsson, S. C., Giovannucci, E., and Wolk, A. Folate and risk of breast cancer: a meta-analysis. J Natl Cancer Inst. 1-3-2007;99:64-76. View abstract.
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497. Clarke, R., Lewington, S., Sherliker, P., and Armitage, J. Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia. Curr Opin.Clin Nutr Metab Care 2007;10:32-39. View abstract.
498. Austen, S. K., Fassett, R. G., Geraghty, D. P., and Coombes, J. S. Folate supplementation fails to affect vascular function and carotid artery intima media thickness in cyclosporin A-treated renal transplant recipients. Clin Nephrol. 2006;66:373-379. View abstract.
499. Badovinac, R. L., Werler, M. M., Williams, P. L., Kelsey, K. T., and Hayes, C. Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Birth Defects Res A Clin Mol.Teratol. 2007;79:8-15. View abstract.
500. Sombolos, K., Papaioannou, A., Christidou, F., Natse, T., Bamichas, G., Gionanlis, L., Katsaris, G., and Progia, E. The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients. Int.Urol.Nephrol. 2006;38(3-4):725-730. View abstract.
501. Lewis, S. J., Harbord, R. M., Harris, R., and Smith, G. D. Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J Natl Cancer Inst. 11-15-2006;98:1607-1622. View abstract.
502. Melse-Boonstra, A., Verhoef, P., West, C. E., van Rhijn, J. A., van Breemen, R. B., Lasaroms, J. J., Garbis, S. D., Katan, M. B., and Kok, F. J. A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses. Am J Clin Nutr 2006;84:1128-1133. View abstract.
503. Berry-Kravis, E., Krause, S. E., Block, S. S., Guter, S., Wuu, J., Leurgans, S., Decle, P., Potanos, K., Cook, E., Salt, J., Maino, D., Weinberg, D., Lara, R., Jardini, T., Cogswell, J., Johnson, S. A., and Hagerman, R. Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. J Child Adolesc.Psychopharmacol 2006;16:525-540. View abstract.
504. Haider, B. A. and Bhutta, Z. A. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database.Syst.Rev 2006;:CD004905. View abstract.
505. Fernandez-Miranda, C., Yebra, M., Aranda, J. L., Gomez, P., Martinez, J., Nunez, V., and Gomez, de la Camara. Effect of folic acid treatment on carotid intima-media thickness of patients with coronary disease. Int J Cardiol 6-12-2007;118:345-349. View abstract.
506. Meijer, W. M., Werler, M. M., Louik, C., Hernandez-Diaz, S., de Jong-van den Berg LT, and Mitchell, A. A. Can folic acid protect against congenital heart defects in Down syndrome? Birth Defects Res A Clin Mol.Teratol. 2006;76:714-717. View abstract.
507. Larsson, S. C., Giovannucci, E., and Wolk, A. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 2006;131:1271-1283. View abstract.
508. Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006;28:680-689. View abstract.
509. Lajous, M., Romieu, I., Sabia, S., Boutron-Ruault, M. C., and Clavel-Chapelon, F. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes Control 2006;17:1209-1213. View abstract.
510. Hubner, R. A., Muir, K. R., Liu, J. F., Sellick, G. S., Logan, R. F., Grainge, M., Armitage, N., Chau, I., and Houlston, R. S. Folate metabolism polymorphisms influence risk of colorectal adenoma recurrence. Cancer Epidemiol.Biomarkers Prev. 2006;15:1607-1613. View abstract.
511. den, Heijer M., Willems, H. P., Blom, H. J., Gerrits, W. B., Cattaneo, M., Eichinger, S., Rosendaal, F. R., and Bos, G. M. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial. Blood 1-1-2007;109:139-144. View abstract.
512. Herrmann, W. Significance of hyperhomocysteinemia. Clin Lab 2006;52(7-8):367-374. View abstract.
513. Arber, N., Eagle, C. J., Spicak, J., Racz, I., Dite, P., Hajer, J., Zavoral, M., Lechuga, M. J., Gerletti, P., Tang, J., Rosenstein, R. B., Macdonald, K., Bhadra, P., Fowler, R., Wittes, J., Zauber, A. G., Solomon, S. D., and Levin, B. Celecoxib for the prevention of colorectal adenomatous polyps. N.Engl.J Med 8-31-2006;355:885-895. View abstract.
514. Bertagnolli, M. M., Eagle, C. J., Zauber, A. G., Redston, M., Solomon, S. D., Kim, K., Tang, J., Rosenstein, R. B., Wittes, J., Corle, D., Hess, T. M., Woloj, G. M., Boisserie, F., Anderson, W. F., Viner, J. L., Bagheri, D., Burn, J., Chung, D. C., Dewar, T., Foley, T. R., Hoffman, N., Macrae, F., Pruitt, R. E., Saltzman, J. R., Salzberg, B., Sylwestrowicz, T., Gordon, G. B., and Hawk, E. T. Celecoxib for the prevention of sporadic colorectal adenomas. N.Engl.J Med 8-31-2006;355:873-884. View abstract.
515. Morris, M. C., Evans, D. A., Schneider, J. A., Tangney, C. C., Bienias, J. L., and Aggarwal, N. T. Dietary folate and vitamins B-12 and B-6 not associated with incident Alzheimer's disease. J Alzheimers.Dis. 2006;9:435-443. View abstract.
516. Eussen, S. J., de Groot, L. C., Joosten, L. W., Bloo, R. J., Clarke, R., Ueland, P. M., Schneede, J., Blom, H. J., Hoefnagels, W. H., and van Staveren, W. A. Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial. Am.J Clin.Nutr 2006;84:361-370. View abstract.
517. Title, L. M., Ur, E., Giddens, K., McQueen, M. J., and Nassar, B. A. Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering. Vasc.Med 2006;11:101-109. View abstract.
518. Olthof, M. R., Bots, M. L., Katan, M. B., and Verhoef, P. Effect of folic acid and betaine supplementation on flow-mediated dilation: a randomized, controlled study in healthy volunteers. PLoS.Clin Trials 2006;1:e10. View abstract.
519. Klingler, M., Blaschitz, A., Campoy, C., Cano, A., Molloy, A. M., Scott, J. M., Dohr, G., Demmelmair, H., Koletzko, B., and Desoye, G. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. Br J Nutr 2006;96:182-190. View abstract.
520. Annerbo, S., Wahlund, L. O., and Lokk, J. The significance of thyroid-stimulating hormone and homocysteine in the development of Alzheimer's disease in mild cognitive impairment: a 6-year follow-up study. Am J Alzheimers.Dis.Other Demen. 2006;21:182-188. View abstract.
521. Pena-Rosas, J. P. and Viteri, F. E. Effects of routine oral iron supplementation with or without folic acid for women during pregnancy. Cochrane.Database.Syst.Rev 2006;3:CD004736. View abstract.
522. McKillop, D. J., McNulty, H., Scott, J. M., McPartlin, J. M., Strain, J. J., Bradbury, I., Girvan, J., Hoey, L., McCreedy, R., Alexander, J., Patterson, B. K., Hannon-Fletcher, M., and Pentieva, K. The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Am J Clin Nutr 2006;84:167-173. View abstract.
523. MacKenzie, K. E., Wiltshire, E. J., Gent, R., Hirte, C., Piotto, L., and Couper, J. J. Folate and vitamin B6 rapidly normalize endothelial dysfunction in children with type 1 diabetes mellitus. Pediatrics 2006;118:242-253. View abstract.
524. Chou, Y. C., Wu, M. H., Yu, J. C., Lee, M. S., Yang, T., Shih, H. L., Wu, T. Y., and Sun, C. A. Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan. Carcinogenesis 2006;27:2295-2300. View abstract.
525. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 7-20-1991;338:131-137. View abstract.
526. Righetti, M., Serbelloni, P., Milani, S., and Ferrario, G. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Blood Purif. 2006;24:379-386. View abstract.
527. Barrios, M. and Alliot, C. Venous thrombosis associated with pernicious anaemia. A report of two cases and review. Hematology. 2006;11:135-138. View abstract.
528. Laitinen, M. H., Ngandu, T., Rovio, S., Helkala, E. L., Uusitalo, U., Viitanen, M., Nissinen, A., Tuomilehto, J., Soininen, H., and Kivipelto, M. Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study. Dement.Geriatr Cogn Disord. 2006;22:99-107. View abstract.
529. Salim, A., Tan, E., Ilchyshyn, A., and Berth-Jones, J. Folic acid supplementation during treatment of psoriasis with methotrexate: a randomized, double-blind, placebo-controlled trial. Br J Dermatol. 2006;154:1169-1174. View abstract.
530. Solfrizzi, V., Colacicco, A. M., D'Introno, A., Capurso, C., Del, Parigi A., Capurso, S. A., Argentieri, G., Capurso, A., and Panza, F. Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging. Exp.Gerontol. 2006;41:619-627. View abstract.
531. Schernthaner, G. H., Plank, C., Minar, E., Bieglmayer, C., Koppensteiner, R., and Schernthaner, G. No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease. Eur J Clin Invest 2006;36:333-339. View abstract.
532. Iwama, T., Akasu, T., Utsunomiya, J., and Muto, T. Does a selective cyclooxygenase-2 inhibitor (tiracoxib) induce clinically sufficient suppression of adenomas in patients with familial adenomatous polyposis? A randomized double-blind placebo-controlled clinical trial. Int J Clin Oncol. 2006;11:133-139. View abstract.
533. Stolzenberg-Solomon, R. Z., Chang, S. C., Leitzmann, M. F., Johnson, K. A., Johnson, C., Buys, S. S., Hoover, R. N., and Ziegler, R. G. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am.J.Clin Nutr. 2006;83:895-904. View abstract.
534. Zoungas, S., McGrath, B. P., Branley, P., Kerr, P. G., Muske, C., Wolfe, R., Atkins, R. C., Nicholls, K., Fraenkel, M., Hutchison, B. G., Walker, R., and McNeil, J. J. Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial. J Am Coll Cardiol 3-21-2006;47:1108-1116. View abstract.
535. Shrubsole, M. J., Gao, Y. T., Cai, Q., Shu, X. O., Dai, Q., Jin, F., and Zheng, W. MTR and MTRR polymorphisms, dietary intake, and breast cancer risk. Cancer Epidemiol.Biomarkers Prev. 2006;15:586-588. View abstract.
536. Lajous, M., Lazcano-Ponce, E., Hernandez-Avila, M., Willett, W., and Romieu, I. Folate, vitamin B, and vitamin B intake and the risk of breast cancer among Mexican women. Cancer Epidemiol.Biomarkers Prev. 2006;15:443-448. View abstract.
537. Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C., and Genest, J., Jr. Homocysteine lowering with folic acid and B vitamins in vascular disease. N.Engl.J Med 4-13-2006;354:1567-1577. View abstract.
538. Labayle, D., Fischer, D., Vielh, P., Drouhin, F., Pariente, A., Bories, C., Duhamel, O., Trousset, M., and Attali, P. Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991;101:635-639. View abstract.
539. Lonn, E., Held, C., Arnold, J. M., Probstfield, J., McQueen, M., Micks, M., Pogue, J., Sheridan, P., Bosch, J., Genest, J., and Yusuf, S. Rationale, design and baseline characteristics of a large, simple, randomized trial of combined folic acid and vitamins B6 and B12 in high-risk patients: the Heart Outcomes Prevention Evaluation (HOPE)-2 trial. Can.J Cardiol 2006;22:47-53. View abstract.
540. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Am Heart J 2006;151:282-287. View abstract.
541. Lewis, S. J., Lawlor, D. A., Davey, Smith G., Araya, R., Timpson, N., Day, I. N., and Ebrahim, S. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol.Psychiatry 2006;11:352-360. View abstract.
542. Pastore, A., De, Angelis S., Casciani, S., Ruggia, R., Di, Giovamberardino G., Noce, A., Splendiani, G., Cortese, C., Federici, G., and Dessi', M. Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes. Clin Chem. 2006;52:145-148. View abstract.
543. Pathansali, R., Mangoni, A. A., Creagh-Brown, B., Lan, Z. C., Ngow, G. L., Yuan, X. F., Ouldred, E. L., Sherwood, R. A., Swift, C. G., and Jackson, S. H. Effects of folic acid supplementation on psychomotor performance and hemorheology in healthy elderly subjects. Arch Gerontol.Geriatr 2006;43:127-137. View abstract.
544. Rossi, E., Hung, J., Beilby, J. P., Knuiman, M. W., Divitini, M. L., and Bartholomew, H. Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia. Ann.Epidemiol. 2006;16:206-212. View abstract.
545. Stott, D. J., MacIntosh, G., Lowe, G. D., Rumley, A., McMahon, A. D., Langhorne, P., Tait, R. C., O'Reilly, D. S., Spilg, E. G., MacDonald, J. B., MacFarlane, P. W., and Westendorp, R. G. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am.J Clin.Nutr 2005;82:1320-1326. View abstract.
546. Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Pantieri, G., and Mariani, E. Conversion of mild cognitive impairment to dementia: predictive role of mild cognitive impairment subtypes and vascular risk factors. Dement.Geriatr Cogn Disord. 2006;21:51-58. View abstract.
547. Huang, T. L., Zandi, P. P., Tucker, K. L., Fitzpatrick, A. L., Kuller, L. H., Fried, L. P., Burke, G. L., and Carlson, M. C. Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4. Neurology 11-8-2005;65:1409-1414. View abstract.
548. Tjonneland, A., Christensen, J., Olsen, A., Stripp, C., Nissen, S. B., Overvad, K., and Thomsen, B. L. Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. Eur.J.Clin Nutr. 2006;60:280-286. View abstract.
549. Mooijaart, S. P., Gussekloo, J., Frolich, M., Jolles, J., Stott, D. J., Westendorp, R. G., and de Craen, A. J. Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus study. Am J Clin Nutr 2005;82:866-871. View abstract.
550. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am.J Clin.Nutr 2005;82:806-812. View abstract.
551. Bailey, L. B. Do low doses of folic acid result in maximum lowering of homocysteine? Am.J Clin.Nutr 2005;82:717-718. View abstract.
552. Huemer, M., Ausserer, B., Graninger, G., Hubmann, M., Huemer, C., Schlachter, K., Tscharre, A., Ulmer, H., and Simma, B. Hyperhomocysteinemia in children treated with antiepileptic drugs is normalized by folic acid supplementation. Epilepsia 2005;46:1677-1683. View abstract.
553. Kuo, H. K., Sorond, F. A., Chen, J. H., Hashmi, A., Milberg, W. P., and Lipsitz, L. A. The role of homocysteine in multisystem age-related problems: a systematic review. J Gerontol.A Biol.Sci Med Sci 2005;60:1190-1201. View abstract.
554. Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., and Licastro, F. Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr 2005;82:636-643. View abstract.
555. Liem, A., Reynierse-Buitenwerf, G. H., Zwinderman, A. H., Jukema, J. W., and van Veldhuisen, D. J. Secondary prevention with folic acid: results of the Goes extension study. Heart 2005;91:1213-1214. View abstract.
556. Potena, L., Grigioni, F., Magnani, G., Ortolani, P., Coccolo, F., Sassi, S., Kessels, K., Marrozzini, C., Marzocchi, A., Carigi, S., Musuraca, A. C., Russo, A., Magelli, C., and Branzi, A. Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study. Am.J Transplant. 2005;5:2258-2264. View abstract.
557. Baglietto, L., English, D. R., Gertig, D. M., Hopper, J. L., and Giles, G. G. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. BMJ 10-8-2005;331:807. View abstract.
558. Virdis, A., Ghiadoni, L., Versari, D., Salvetti, G., Pinto, S., Favilla, S., Taddei, S., and Salvetti, A. Is Hyperhomocyst(e)inemia a humoral predictor of coronary heart disease? Curr Pharm Des 2005;11:2187-2197. View abstract.
559. Williams, C., Kingwell, B. A., Burke, K., McPherson, J., and Dart, A. M. Folic acid supplementation for 3 wk reduces pulse pressure and large artery stiffness independent of MTHFR genotype. Am J Clin Nutr 2005;82:26-31. View abstract.
560. Cook, N. R., Lee, I. M., Gaziano, J. M., Gordon, D., Ridker, P. M., Manson, J. E., Hennekens, C. H., and Buring, J. E. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 7-6-2005;294:47-55. View abstract.
561. Cronin, S., Furie, K. L., and Kelly, P. J. Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis. Stroke 2005;36:1581-1587. View abstract.
562. Till, U., Rohl, P., Jentsch, A., Till, H., Muller, A., Bellstedt, K., Plonne, D., Fink, H. S., Vollandt, R., Sliwka, U., Herrmann, F. H., Petermann, H., and Riezler, R. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12. Atherosclerosis 2005;181:131-135. View abstract.
563. Carrero, J. J., Lopez-Huertas, E., Salmeron, L. M., Baro, L., and Ros, E. Daily supplementation with (n-3) PUFAs, oleic acid, folic acid, and vitamins B-6 and E increases pain-free walking distance and improves risk factors in men with peripheral vascular disease. J.Nutr. 2005;135:1393-1399. View abstract.
564. Garcia-Closas, R., Castellsague, X., Bosch, X., and Gonzalez, C. A. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int.J.Cancer 11-20-2005;117:629-637. View abstract.
565. Lewerin, C., Matousek, M., Steen, G., Johansson, B., Steen, B., and Nilsson-Ehle, H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. Am.J Clin.Nutr 2005;81:1155-1162. View abstract.
566. Sachdev, P. S., Parslow, R. A., Lux, O., Salonikas, C., Wen, W., Naidoo, D., Christensen, H., and Jorm, A. F. Relationship of homocysteine, folic acid and vitamin B12 with depression in a middle-aged community sample. Psychol.Med 2005;35:529-538. View abstract.
567. Felkner, M., Suarez, L., Hendricks, K., and Larsen, R. Implementation and outcomes of recommended folic acid supplementation in Mexican-American women with prior neural tube defect-affected pregnancies. Prev.Med 2005;40:867-871. View abstract.
568. Lopez-Camelo, J. S., Orioli, I. M., da Graca, Dutra M., Nazer-Herrera, J., Rivera, N., Ojeda, M. E., Canessa, A., Wettig, E., Fontannaz, A. M., Mellado, C., and Castilla, E. E. Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile. Am.J.Med.Genet.A 6-1-2005;135:120-125. View abstract.
569. Ranganathan, L. N. and Ramaratnam, S. Vitamins for epilepsy. Cochrane.Database.Syst.Rev 2005;:CD004304. View abstract.
570. Brattstrom, L., Lindgren, A., Israelsson, B., Malinow, M. R., Norrving, B., Upson, B., and Hamfelt, A. Hyperhomocysteinaemia in stroke: prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 1992;22:214-221. View abstract.
571. Charles, D. H., Ness, A. R., Campbell, D., Smith, G. D., Whitley, E., and Hall, M. H. Folic acid supplements in pregnancy and birth outcome: re-analysis of a large randomised controlled trial and update of Cochrane review. Paediatr.Perinat.Epidemiol. 2005;19:112-124. View abstract.
572. Mangoni, A. A., Sherwood, R. A., Asonganyi, B., Swift, C. G., Thomas, S., and Jackson, S. H. Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes. Am J Hypertens. 2005;18(2 Pt 1):220-226. View abstract.
573. Chen, J., Gammon, M. D., Chan, W., Palomeque, C., Wetmur, J. G., Kabat, G. C., Teitelbaum, S. L., Britton, J. A., Terry, M. B., Neugut, A. I., and Santella, R. M. One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer. Cancer Res 2-15-2005;65:1606-1614. View abstract.
574. Ziegler, S., Mittermayer, F., Plank, C., Minar, E., Wolzt, M., and Schernthaner, G. H. Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease. J Clin Endocrinol.Metab 2005;90:2175-2178. View abstract.
575. Lekakis, J. P., Papamichael, C. M., Papaioannou, T. G., Dagre, A. G., Stamatelopoulos, K. S., Tryfonopoulos, D., Protogerou, A. D., Stamatelopoulos, S. F., and Mavrikakis, M. Oral folic acid enhances endothelial function in patients with hypercholesterolaemia receiving statins. Eur J Cardiovasc.Prev.Rehabil 2004;11:416-420. View abstract.
576. Connor, S. L., Ojeda, L. S., Sexton, G., Weidner, G., and Connor, W. E. Diets lower in folic acid and carotenoids are associated with the coronary disease epidemic in Central and Eastern Europe. J Am Diet Assoc 2004;104:1793-1799. View abstract.
577. Spoelstra-de, M. A., Brouwer, C. B., Terheggen, F., Bollen, J. M., Stehouwer, C. D., and Smulders, Y. M. No effect of folic acid on markers of endothelial dysfunction or inflammation in patients with type 2 diabetes mellitus and mild hyperhomocysteinaemia. Neth.J Med 2004;62:246-253. View abstract.
578. Czeizel, A. E., Dobo, M., and Vargha, P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Res A Clin Mol.Teratol. 2004;70:853-861. View abstract.
579. Sanjoaquin, M. A., Allen, N., Couto, E., Roddam, A. W., and Key, T. J. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer 2-20-2005;113:825-828. View abstract.
580. Deol, P. S., Barnes, T. A., Dampier, K., John, Pasi K., Oppenheimer, C., and Pavord, S. R. The effects of folic acid supplements on coagulation status in pregnancy. Br.J.Haematol. 2004;127:204-208. View abstract.
581. Schmiegel, W., Pox, C., and Kroesen, A. [Ulcerative colitis. Cancer prevention]. Z Gastroenterol 2004;42:1014-1018. View abstract.
582. Liu, S., West, R., Randell, E., Longerich, L., O'connor, K. S., Scott, H., Crowley, M., Lam, A., Prabhakaran, V., and McCourt, C. A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects. BMC.Pregnancy.Childbirth. 9-27-2004;4:20. View abstract.
583. Ramos, M. I., Allen, L. H., Haan, M. N., Green, R., and Miller, J. W. Plasma folate concentrations are associated with depressive symptoms in elderly Latina women despite folic acid fortification. Am J Clin Nutr 2004;80:1024-1028. View abstract.
584. Carlsson, C. M., Pharo, L. M., Aeschlimann, S. E., Mitchell, C., Underbakke, G., and Stein, J. H. Effects of multivitamins and low-dose folic acid supplements on flow-mediated vasodilation and plasma homocysteine levels in older adults. Am Heart J 2004;148:E11. View abstract.
585. Hvas, A. M., Juul, S., Lauritzen, L., Nexo, E., and Ellegaard, J. No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study. J Affect.Disord. 2004;81:269-273. View abstract.
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