What is HIV/AIDS?
HIV stands for human immunodeficiency virus. It harms your immune system by destroying CD4 cells. These are a type of white blood cells that fight infection. The loss of these cells makes it hard for your body to fight off infections and certain HIV-related cancers.
Without treatment, HIV can gradually destroy the immune system and advance to AIDS. AIDS stands for acquired immunodeficiency syndrome. It is the final stage of infection with HIV. Not everyone with HIV develops AIDS.
What is antiretroviral therapy (ART)?
The treatment of HIV/AIDS with medicines is called antiretroviral therapy (ART). It is recommended for everyone who has HIV. The medicines do not cure HIV infection, but they do make it a manageable chronic condition. They also reduce the risk of spreading the virus to others.
How do HIV/AIDS medicines work?
HIV/AIDS medicines reduce the amount of HIV (viral load) in your body, which helps by
- Giving your immune system a chance to recover. Even though there is still some HIV in your body, your immune system should be strong enough to fight off infections and certain HIV-related cancers.
- Reducing the risk that you will spread HIV to others
What are the types of HIV/AIDS medicines?
There are several different types of HIV/AIDS medicines. Some work by blocking or changing enzymes that HIV needs to make copies of itself. This prevents HIV from copying itself, which reduces the amount of HIV in the body. Several medicines do this:
- Nucleoside reverse transcriptase inhibitors (NRTIs) block the reverse transcriptase enzyme
- Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and later change the reverse transcriptase enzyme
- Integrase inhibitors block the integrase enzyme
- Protease inhibitors (PIs) block the protease enzyme
Some HIV/AIDS medicines interfere with HIV's ability to infect CD4 immune system cells:
- Fusion inhibitors block HIV from entering the cells
- CCR5 antagonists and post-attachment inhibitors block different molecules on the CD4 cells. To infect a cell, HIV has to bind to two types of molecules on the cell's surface. Blocking either of these molecules prevents HIV from entering the cells.
In some cases, people take more than one medicine:
- Pharmacokinetic enhancers boost the effectiveness of certain HIV/AIDS medicines. A pharmacokinetic enhancer slows the breakdown of the other medicine. This allows that medicine to stay in the body longer at a higher concentration.
- Multidrug combinations include a combination of two or more different HIV/AIDS medicines
When do I need to start taking HIV/AIDS medicines?
It's important to start taking HIV/AIDS medicines as soon as possible after your diagnosis, especially if you
- Are pregnant
- Have AIDS
- Have certain HIV-related illnesses and infections
- Have an early HIV infection (the first 6 months after infection with HIV)
What else do I need to know about taking HIV/AIDS medicines?
It's important to take your medicines every day, according to the instructions from your health care provider. If you miss doses or don't follow a regular schedule, your treatment may not work and the HIV virus may become resistant to the medicines.
HIV medicines can cause side effects. Most of these side effects are manageable, but a few can be serious. Tell your health care provider about any side effects you are having. Don't stop taking your medicine without first talking to your provider. He or she may give you tips on how to deal with the side effects. In some cases, your provider may decide to change your medicines.
- AIDSinfo Drug Database (AIDSinfo) Also in Spanish
- FDA-Approved HIV Medicines (AIDSinfo) Also in Spanish
- HIV and AIDS: Medicines to Help You (Food and Drug Administration)
- HIV Treatment: The Basics (AIDSinfo)
- HIV/AIDS Treatment (National Institute of Allergy and Infectious Diseases)
- Treatment for HIV (Department of Veterans Affairs)
- Are You Taking Medication as Prescribed? (Food and Drug Administration)
- CDC Vital Signs: HIV Care Saves Lives Also in Spanish
- Drug Dosing Toolkit (Department of Veterans Affairs)
- Drug Resistance (AIDSinfo) Also in Spanish
- Following an HIV Regimen: Steps to Take Before and After Starting HIV Medicines (AIDSinfo) Also in Spanish
- HIV Medication Adherence (AIDSinfo) Also in Spanish
- HIV Medicines and Side Effects (AIDSinfo) Also in Spanish
- HIV Resistance Testing (New Mexico AIDS Education and Training Center) Also in Spanish
- HIV Treatment Overview (AIDS.gov)
- Post-Exposure Prophylaxis (AIDS.gov)
- Post-Exposure Prophylaxis (PEP) (AIDSinfo) Also in Spanish
- Pre-Exposure Prophylaxis (PrEP) (AIDS.gov)
- PrEP (Pre-Exposure Prophylaxis) 101 (Centers for Disease Control and Prevention) Also in Spanish
- Recreational Drugs and HIV (New Mexico AIDS Education and Training Center) Also in Spanish
- Side Effects of HIV Medicines: HIV and Diabetes (AIDSinfo) Also in Spanish
- Side Effects of HIV Medicines: HIV and Hepatotoxicity (AIDSinfo) Also in Spanish
- Side Effects of HIV Medicines: HIV and Lactic Acidosis (AIDSinfo) Also in Spanish
- Side Effects of HIV Medicines: HIV and Lipodystrophy (AIDSinfo) Also in Spanish
- Side Effects of HIV Medicines: HIV and Osteoporosis (AIDSinfo) Also in Spanish
- Side Effects of HIV Medicines: HIV and Rash (AIDSinfo) Also in Spanish
- What to Start: Selecting a First HIV Regimen (AIDSinfo) Also in Spanish
- When to Start Antiretroviral Therapy (AIDSinfo)
- Antiretroviral Drugs Used in the Treatment of HIV Infection (Food and Drug Administration)
- HIV Treatment: What is a Drug Interaction? (AIDSinfo) Also in Spanish
- What is an Investigational HIV Drug? (AIDSinfo) Also in Spanish
- Drugs That Fight HIV-1 (AIDSinfo) - PDF
- ClinicalTrials.gov: Anti-HIV Agents (National Institutes of Health)
- ClinicalTrials.gov: Antiretroviral Therapy, Highly Active (National Institutes of Health)
- ClinicalTrials.gov: Pre-Exposure Prophylaxis (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: DOLAMA study: Effectiveness, safety and pharmacoeconomic analysis of dual therapy with...
- Article: Safety and efficacy of elvitegravir, dolutegravir, and raltegravir in a real-world...
- Article: Longitudinal virological outcomes and factors associated with virological failure in behaviorally...
- HIV/AIDS Medicines -- see more articles