About 30 to 40% of people in the United States get an H. pylori infection. Most people get it as a child. H. pylori usually does not cause symptoms. But it can break down the inner protective coating in some people's stomachs and cause inflammation. This can lead to gastritis or a peptic ulcer.
Researchers aren't sure how H. pylori spreads. They think that it may spread by unclean food and water, or through contact with an infected person's saliva and other body fluids.
A peptic ulcer causes a dull or burning pain in your stomach, especially when you have an empty stomach. It lasts for minutes to hours, and it may come and go for several days or weeks. It may also cause other symptoms, such as bloating, nausea, and weight loss. If you have the symptoms of a peptic ulcer, your health care provider will check to see whether you have H. pylori. There are blood, breath, and stool tests to check for H. pylori. In some cases, you may need an upper endoscopy, often with a biopsy.
If you do have a peptic ulcer, the treatment is with a combination of antibiotics and acid-reducing medicines. You will need to be tested again after treatment to make sure the infection is gone.
There is no vaccine for H. pylori. Since H. pylori might spread through unclean food and water, you might be able to prevent it if you:
- Wash your hands after using the bathroom and before eating
- Eat properly prepared food
- Drink water from a clean, safe source
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
- Helicobacter pylori (Nemours Foundation)
- Definition and Facts for Peptic Ulcers (Stomach Ulcers) (National Institute of Diabetes and Digestive and Kidney Diseases)
- Helicobacter pylori and Cancer (National Cancer Institute) Also in Spanish
- ClinicalTrials.gov: Helicobacter Infections (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Altered Gut Microbiota and Short-Chain Fatty Acids After Vonoprazan-Amoxicillin Dual Therapy...
- Article: Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human...
- Article: Nitazoxanide-based therapeutic regimen as a novel treatment for Helicobacter pylori infection...
- Helicobacter Pylori Infections -- see more articles