Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis, is a rare disease. It is a type of vasculitis, or inflammation of the blood vessels. The inflammation limits the flow of blood to important organs, causing damage. It can affect any organ, but it mainly affects the sinuses, nose, trachea (windpipe), lungs, and kidneys.
The cause of GPA is unknown. It can affect people at any age. Men and women are equally affected. It is more common in whites. Symptoms may include joint pain, weakness, tiredness, and cold symptoms such as a runny nose that doesn't get better. Doctors use blood tests, chest X-rays, and biopsies to diagnose GPA and rule out other causes of the symptoms.
Early treatment is important. Most people improve with medicines to slow or stop the inflammation.
NIH: National Institute of Allergy and Infectious Diseases
- ANCA / MPO / PR3 Antibodies Test (American Association for Clinical Chemistry)
- Cyclophosphamide (Cytoxan) (Johns Hopkins Vasculitis Center)
- ESR (Erythrocyte Sedimentation Rate) Test (American Association for Clinical Chemistry)
- Granulomatosis with Polyangiitis (Mayo Foundation for Medical Education and Research)
- Granulomatosis with Polyangiitis (GPA) (National Institute of Allergy and Infectious Diseases)
- Granulomatosis with Polyangiitis (GPA): Symptoms and Causes (Mayo Foundation for Medical Education and Research)
- Granulomatosis with Polyangiitis (Wegener's) (American College of Rheumatology)
- Wegener's Granulomatosis (Johns Hopkins Vasculitis Center)
- Genetics Home Reference: granulomatosis with polyangiitis (National Library of Medicine)
- ClinicalTrials.gov: Granulomatosis with Polyangiitis (National Institutes of Health)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Clinical overlap in proximal artery stenosis: two disorders or one?
- Article: Proximal pulmonary artery stenosis: a rare manifestation of granulomatosis with...
- Article: IMAGES IN CLINICAL MEDICINE. Gastrointestinal Complication of Granulomatosis with Polyangiitis.
- Granulomatosis with Polyangiitis -- see more articles