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SLITRK1 gene

SLIT and NTRK like family member 1

Normal Function

The SLITRK1 gene provides instructions for making a protein that is a member of the SLITRK family. Proteins in this family are found in the brain, where they play a role in the growth and development of nerve cells. The SLITRK1 protein may help guide the growth of specialized extensions (axons and dendrites) that allow each nerve cell to communicate with nearby cells.

Health Conditions Related to Genetic Changes

Tourette syndrome

Mutations involving the SLITRK1 gene have been identified in a small number of people with Tourette syndrome. One of these mutations, written as del1264C, deletes a single DNA building block (base pair) from the gene. This mutation leads to the production of an abnormally short, nonfunctional version of the SLITRK1 protein. Another mutation changes a single base pair in a region of DNA near the gene. This change probably interferes with production of the SLITRK1 protein. Although the SLITRK1 gene is active in areas of the brain known to be involved in Tourette syndrome, it is unclear how mutations in or near the gene lead to the behavioral features of this condition. Because mutations have been reported in so few people with Tourette syndrome, the association of the SLITRK1 gene with this disorder has not been confirmed.

More About This Health Condition

Other Names for This Gene

  • KIAA0918
  • KIAA1910
  • leucine rich repeat containing 12
  • LRRC12
  • SLIT and NTRK-like family, member 1
  • slit and trk like 1 protein
  • slit and trk like gene 1

Additional Information & Resources

Tests Listed in the Genetic Testing Registry

Scientific Articles on PubMed

Catalog of Genes and Diseases from OMIM

Gene and Variant Databases


  • Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State MW. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005 Oct 14;310(5746):317-20. doi: 10.1126/science.1116502. Citation on PubMed
  • Aruga J, Yokota N, Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. Gene. 2003 Oct 2;315:87-94. doi: 10.1016/s0378-1119(03)00715-7. Citation on PubMed
  • Deng H, Le WD, Xie WJ, Jankovic J. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. Acta Neurol Scand. 2006 Dec;114(6):400-2. doi: 10.1111/j.1600-0404.2006.00706.x. Citation on PubMed
  • Grados MA, Walkup JT. A new gene for Tourette's syndrome: a window into causal mechanisms? Trends Genet. 2006 Jun;22(6):291-3. doi: 10.1016/j.tig.2006.04.003. Epub 2006 May 4. Citation on PubMed
  • Olson S. Medicine. Teenager's odd chromosome points to possible Tourette syndrome gene. Science. 2005 Oct 14;310(5746):211. doi: 10.1126/science.310.5746.211a. No abstract available. Citation on PubMed

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.