Health Conditions Related to Genetic Changes
Primary localized cutaneous amyloidosis
At least 13 mutations in the OSMR gene have been found to cause primary localized cutaneous amyloidosis (PLCA) type 1, an itchy skin condition in which clumps of abnormal proteins called amyloids build up in the skin. These mutations change single protein building blocks (amino acids) in OSMRβ. Most alter a region of the protein thought to interact with the other subunit of the OSM receptor type II or the IL-31 receptor and may impair formation of these receptors.
OSMR gene mutations reduce the chemical signals triggered by OSM and IL-31. Researchers speculate that this reduced signaling may make cells more likely to undergo apoptosis. Some studies suggest that apoptosis of skin cells releases abnormal proteins that form amyloids. It has been suggested that apoptosis is triggered by scratching the itchy skin, but the role of OSMR gene changes in skin itching is not clear.
More About This Health ConditionOther Names for This Gene
- IL-31 receptor subunit beta
- IL-31R subunit beta
- IL-31R-beta
- IL-31RB
- interleukin-31 receptor subunit beta
- oncostatin-M specific receptor beta subunit
- OSMRB
- PLCA1
Additional Information & Resources
Tests Listed in the Genetic Testing Registry
Scientific Articles on PubMed
Catalog of Genes and Diseases from OMIM
References
- Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, Odashiro M, Odashiro DN, Hans-Neto G, Hans NR, Holder MV, Bhogal BS, Hartshorne ST, Akiyama M, Shimizu H, McGrath JA. Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. Am J Hum Genet. 2008 Jan;82(1):73-80. doi: 10.1016/j.ajhg.2007.09.002. Citation on PubMed or Free article on PubMed Central
- Chang YT, Wong CK, Chow KC, Tsai CH. Apoptosis in primary cutaneous amyloidosis. Br J Dermatol. 1999 Feb;140(2):210-5. doi: 10.1111/j.1365-2133.1999.02651.x. Citation on PubMed
- Hermanns HM. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58. doi: 10.1016/j.cytogfr.2015.07.006. Epub 2015 Jul 3. Citation on PubMed
- Lin MW, Lee DD, Liu TT, Lin YF, Chen SY, Huang CC, Weng HY, Liu YF, Tanaka A, Arita K, Lai-Cheong J, Palisson F, Chang YT, Wong CK, Matsuura I, McGrath JA, Tsai SF. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 2010 Jan;18(1):26-32. doi: 10.1038/ejhg.2009.135. Citation on PubMed or Free article on PubMed Central
- Wali A, Liu L, Takeichi T, Jelani M, Rahman OU, Heng YK, Thng S, Lee J, Akiyama M, McGrath JA, Betz RC. Familial primary localized cutaneous amyloidosis results from either dominant or recessive mutations in OSMR. Acta Derm Venereol. 2015 Nov;95(8):1005-7. doi: 10.2340/00015555-2104. No abstract available. Citation on PubMed
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