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MAT1A gene

methionine adenosyltransferase 1A
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Normal Function

The MAT1A gene provides instructions for producing the enzyme methionine adenosyltransferase. The enzyme is produced from the MAT1A gene in two forms, designated alpha and beta. The alpha form, called a homotetramer, is made up of four identical protein subunits. The beta form, called a homodimer, is made up of two of the same protein subunits. Both forms of the enzyme are found in the liver.

Both the alpha and beta forms of methionine adenosyltransferase help break down a protein building block (amino acid) called methionine. The enzyme starts the reaction that converts methionine to S-adenosylmethionine, also called AdoMet or SAMe. AdoMet is involved in transferring methyl groups, consisting of a carbon atom and three hydrogen atoms, to other compounds, a process called transmethylation. Transmethylation is important in many cellular processes. These include determining whether the instructions in a particular segment of DNA are carried out, regulating reactions involving proteins and lipids, and controlling the processing of chemicals that relay signals in the nervous system (neurotransmitters).

Health Conditions Related to Genetic Changes

Hypermethioninemia

Approximately 15 mutations in the MAT1A gene have been found to reduce the activity of the methionine adenosyltransferase enzyme. Most of these mutations substitute one amino acid for another amino acid in the enzyme, causing it to process methionine less efficiently. Other mutations introduce a premature stop signal in the instructions for making the methionine adenosyltransferase enzyme. As a result, a shortened, nonfunctional enzyme is produced. A reduction in methionine adenosyltransferase function results in a buildup of methionine in the body and less efficient AdoMet production, and in severe cases can cause neurological problems.

More About This Health Condition

Other Names for This Gene

  • MAT
  • MATA1
  • methionine adenosyltransferase I, alpha
  • METK1_HUMAN
  • S-adenosylmethionine synthetase 1
  • SAMS
  • SAMS, liver-specific
  • SAMS1

Additional Information & Resources

Tests Listed in the Genetic Testing Registry

Scientific Articles on PubMed

Catalog of Genes and Diseases from OMIM

Research Resources

References

  • Biochemistry (fifth edition, 2002): Methionine Metabolism
  • Chamberlin ME, Ubagai T, Mudd SH, Thomas J, Pao VY, Nguyen TK, Levy HL, Greene C, Freehauf C, Chou JY. Methionine adenosyltransferase I/III deficiency: novel mutations and clinical variations. Am J Hum Genet. 2000 Feb;66(2):347-55. Citation on PubMed or Free article on PubMed Central
  • Chien YH, Chiang SC, Huang A, Hwu WL. Spectrum of hypermethioninemia in neonatal screening. Early Hum Dev. 2005 Jun;81(6):529-33. Epub 2004 Dec 19. Citation on PubMed
  • Chou JY. Molecular genetics of hepatic methionine adenosyltransferase deficiency. Pharmacol Ther. 2000 Jan;85(1):1-9. Review. Citation on PubMed
  • Smythies JR, Gottfries CG, Regland B. Disturbances of one-carbon metabolism in neuropsychiatric disorders: a review. Biol Psychiatry. 1997 Jan 15;41(2):230-3. Review. Citation on PubMed
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