Health Conditions Related to Genetic Changes
Leukocyte adhesion deficiency type 1
At least 90 mutations in the ITGB2 gene have been found to cause leukocyte adhesion deficiency type 1. This condition is characterized by severe, recurrent infections and delayed healing after injury. Many of the mutations that cause this condition change single protein building blocks (amino acids) in the β2 subunit and lead to the production of a β2 subunit that cannot bind with other subunits to form integrins. Rarely, defective β2 subunits are able to form integrins, but the integrins cannot bind ligands. Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. As a result, there is a decreased response to injury and foreign invaders, such as bacteria and fungi, resulting in frequent infections, delayed wound healing, and other signs and symptoms of leukocyte adhesion deficiency type 1.
More About This Health ConditionOther Names for This Gene
- CD11b/ CD18
- CD11c/CD18
- CD11d/CD18
- CD18
- complement receptor C3 beta-subunit
- complement receptor C3 subunit beta
- CR3
- integrin beta 2
- integrin beta chain, beta 2
- integrin beta-2
- integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
- LFA-1 (αLβ2)
- Mac-1 (αMβ2)
- p150/95 (αXβ2)
- αDβ2
Additional Information & Resources
Tests Listed in the Genetic Testing Registry
Scientific Articles on PubMed
Catalog of Genes and Diseases from OMIM
References
- Parvaneh N, Mamishi S, Rezaei A, Rezaei N, Tamizifar B, Parvaneh L, Sherkat R, Ghalehbaghi B, Kashef S, Chavoshzadeh Z, Isaeian A, Ashrafi F, Aghamohammadi A. Characterization of 11 new cases of leukocyte adhesion deficiency type 1 with seven novel mutations in the ITGB2 gene. J Clin Immunol. 2010 Sep;30(5):756-60. doi: 10.1007/s10875-010-9433-2. Epub 2010 Jun 12. Citation on PubMed
- Schmidt S, Moser M, Sperandio M. The molecular basis of leukocyte recruitment and its deficiencies. Mol Immunol. 2013 Aug;55(1):49-58. doi: 10.1016/j.molimm.2012.11.006. Epub 2012 Dec 17. Citation on PubMed
- van de Vijver E, Maddalena A, Sanal O, Holland SM, Uzel G, Madkaikar M, de Boer M, van Leeuwen K, Koker MY, Parvaneh N, Fischer A, Law SK, Klein N, Tezcan FI, Unal E, Patiroglu T, Belohradsky BH, Schwartz K, Somech R, Kuijpers TW, Roos D. Hematologically important mutations: leukocyte adhesion deficiency (first update). Blood Cells Mol Dis. 2012 Jan 15;48(1):53-61. doi: 10.1016/j.bcmd.2011.10.004. Epub 2011 Nov 30. Citation on PubMed or Free article on PubMed Central
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