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F7 gene

coagulation factor VII

Normal Function

The F7 gene provides instructions for making a protein called coagulation factor VII. Coagulation factors are a group of related proteins that are involved in the coagulation system, which is a series of chemical reactions that form blood clots. After an injury, clots seal off blood vessels to stop bleeding and trigger blood vessel repair.

Coagulation factor VII is made primarily by cells in the liver. The protein circulates in the bloodstream in an inactive form until the coagulation system is turned on (activated) by an injury that damages blood vessels. Activated coagulation factor VII helps turn on other coagulation factors in turn. This step-wise process ultimately promotes the conversion of an important coagulation protein called fibrinogen into fibrin, which is the material that forms blood clots.

Health Conditions Related to Genetic Changes

Factor VII deficiency

Almost 300 mutations in the F7 gene have been found to cause a rare bleeding disorder called factor VII deficiency. This disorder commonly causes nosebleeds, easy bruising, bleeding of the gums, and prolonged or excessive bleeding following surgery or physical injury. In severe cases, life-threatening episodes of bleeding inside the skull or gastrointestinal tract can occur. Some affected individuals have no bleeding problems. The F7 gene mutations involved in this condition reduce the amount of coagulation factor VII in the bloodstream. A shortage of coagulation factor VII prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe. What determines the severity of the condition is unclear; it does not appear to be related to the amount of coagulation factor VII in the blood.

More About This Health Condition

Other Names for This Gene

  • FVII coagulation protein
  • proconvertin
  • serum prothrombin conversion accelerator
  • SPCA

Additional Information & Resources

Tests Listed in the Genetic Testing Registry

Scientific Articles on PubMed

Catalog of Genes and Diseases from OMIM

Gene and Variant Databases


  • Girolami A, Cosi E, Santarossa C, Ferrari S, Luigia Randi M. The Story of Serum Prothrombin Conversion Accelerator, Proconvertin, Stable Factor, Cothromboplastin, Prothrombin Accelerator or Autoprothrombin I, and Their Subsequent Merging into Factor VII. Semin Thromb Hemost. 2015 Jun;41(4):366-73. doi: 10.1055/s-0035-1549851. Epub 2015 May 14. Citation on PubMed
  • Herrmann FH, Wulff K, Auerswald G, Schulman S, Astermark J, Batorova A, Kreuz W, Pollmann H, Ruiz-Saez A, De Bosch N, Salazar-Sanchez L; Greifswald Factor FVII Deficiency Study Group. Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. Haemophilia. 2009 Jan;15(1):267-80. doi: 10.1111/j.1365-2516.2008.01910.x. Epub 2008 Oct 30. Citation on PubMed
  • Mariani G, Bernardi F. Factor VII Deficiency. Semin Thromb Hemost. 2009 Jun;35(4):400-6. doi: 10.1055/s-0029-1225762. Epub 2009 Jul 13. Citation on PubMed
  • Mariani G, Herrmann FH, Bernardi F, Schved JF, Auerswald G, Ingerslev J. Clinical manifestations, management, and molecular genetics in congenital factor VII deficiency: the International Registry on Congenital Factor VII Deficiency (IRF7). Blood. 2000 Jul 1;96(1):374. No abstract available. Citation on PubMed
  • Mariani G, Herrmann FH, Dolce A, Batorova A, Etro D, Peyvandi F, Wulff K, Schved JF, Auerswald G, Ingerslev J, Bernardi F; International Factor VII Deficiency Study Group. Clinical phenotypes and factor VII genotype in congenital factor VII deficiency. Thromb Haemost. 2005 Mar;93(3):481-7. doi: 10.1160/TH04-10-0650. Citation on PubMed

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.