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CDKN1B gene

cyclin dependent kinase inhibitor 1B

Normal Function

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, where it plays a critical role in controlling cell growth and division. It helps regulate the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion. Specifically, p27 normally blocks cells from entering the phase of the cell cycle when DNA is copied (replicated) in preparation for cell division. By blocking cell cycle progression, p27 prevents cells from dividing too quickly or at the wrong time. Based on this function, p27 is described as a tumor suppressor protein. Studies suggest that p27 is also involved in controlling cell differentiation, which is the process by which cells mature to carry out specific functions.

Because p27 plays such a key role in controlling cell division, its activity is tightly regulated. Regulation can occur through modification of the p27 protein's structure, its interaction with other proteins, or its localization within the cell. For example, when p27 is held (sequestered) in the fluid that surrounds the nucleus (the cytoplasm) instead of being transported into the nucleus, the protein is unavailable to block cell cycle progression. Researchers believe that p27 may have other functions in the cytoplasm, but these functions have not been well described.

Health Conditions Related to Genetic Changes

Multiple endocrine neoplasia

At least eight mutations in the CDKN1B gene have been found to cause a relatively rare form of multiple endocrine neoplasia called type 4. Multiple endocrine neoplasia typically involves the development of tumors in two or more of the body's hormone-producing glands, called endocrine glands. These tumors can be noncancerous or cancerous. The most common endocrine glands affected in multiple endocrine neoplasia type 4 are the parathyroid glands and the pituitary gland, although additional endocrine glands and other organs can also be involved.

Most of the CDKN1B gene mutations that cause multiple endocrine neoplasia type 4 change single protein building blocks (amino acids) in the p27 protein. Some mutations impair the protein's ability to interact with regulatory proteins, while others lead to the production of an unstable version of p27 that is quickly broken down. Still other mutations prevent p27 from moving from the cytoplasm into the nucleus. All of these mutations reduce the amount of functional p27 that is available in the nucleus to regulate the cell cycle. Cells with a shortage of functional p27 can divide too quickly or in an uncontrolled way, forming a tumor. It is unclear why these tumors occur primarily in endocrine glands; studies suggest that certain endocrine cells may be particularly dependent on the p27 protein to control cell division.

More About This Health Condition

Other tumors

Mutations in the CDKN1B gene have also been found to cause tumors in single endocrine glands, such as the pituitary gland or the parathyroid glands. These mutations are described as somatic; they are not inherited and are present only in tumor cells. Somatic CDKN1B gene mutations have been identified in sporadic (nonfamilial) pituitary adenomas and in sporadic parathyroid adenomas, which are noncancerous tumors of the parathyroid glands. Like the mutations that cause multiple endocrine neoplasia type 4, these genetic changes reduce the amount of functional p27 available to control cell division. As a result, cells become more likely to divide abnormally and form a tumor.

Apart from multiple endocrine neoplasia, the CDKN1B gene is rarely mutated in cancerous tumors. However, changes in regulation that reduce the amount or function of the p27 protein in the nucleus are found in many types of cancer. A shortage of p27 has been associated with more aggressive tumors and a poorer prognosis.

Other Names for This Gene

  • CDKN4
  • cyclin-dependent kinase inhibitor 1B
  • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
  • KIP1
  • MEN1B
  • MEN4
  • P27KIP1

Additional Information & Resources

Tests Listed in the Genetic Testing Registry

Scientific Articles on PubMed

Catalog of Genes and Diseases from OMIM

Gene and Variant Databases


  • Costa-Guda J, Marinoni I, Molatore S, Pellegata NS, Arnold A. Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas. J Clin Endocrinol Metab. 2011 Apr;96(4):E701-6. doi: 10.1210/jc.2010-1338. Epub 2011 Feb 2. Citation on PubMed or Free article on PubMed Central
  • Lee M, Pellegata NS. Multiple endocrine neoplasia type 4. Front Horm Res. 2013;41:63-78. doi: 10.1159/000345670. Epub 2013 Mar 19. Citation on PubMed
  • Marinoni I, Pellegata NS. p27kip1: a new multiple endocrine neoplasia gene? Neuroendocrinology. 2011;93(1):19-28. doi: 10.1159/000320366. Epub 2010 Oct 27. Citation on PubMed
  • Molatore S, Pellegata NS. The MENX syndrome and p27: relationships with multiple endocrine neoplasia. Prog Brain Res. 2010;182:295-320. doi: 10.1016/S0079-6123(10)82013-8. Citation on PubMed
  • Pellegata NS, Quintanilla-Martinez L, Siggelkow H, Samson E, Bink K, Hofler H, Fend F, Graw J, Atkinson MJ. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15558-63. doi: 10.1073/pnas.0603877103. Epub 2006 Oct 9. Erratum In: Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19213. Citation on PubMed or Free article on PubMed Central
  • Pellegata NS. MENX and MEN4. Clinics (Sao Paulo). 2012;67 Suppl 1(Suppl 1):13-8. doi: 10.6061/clinics/2012(sup01)04. Citation on PubMed or Free article on PubMed Central
  • Tichomirowa MA, Lee M, Barlier A, Daly AF, Marinoni I, Jaffrain-Rea ML, Naves LA, Rodien P, Rohmer V, Faucz FR, Caron P, Estour B, Lecomte P, Borson-Chazot F, Penfornis A, Yaneva M, Guitelman M, Castermans E, Verhaege C, Wemeau JL, Tabarin A, Fajardo Montanana C, Delemer B, Kerlan V, Sadoul JL, Cortet Rudelli C, Archambeaud F, Zacharieva S, Theodoropoulou M, Brue T, Enjalbert A, Bours V, Pellegata NS, Beckers A. Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds. Endocr Relat Cancer. 2012 May 3;19(3):233-41. doi: 10.1530/ERC-11-0362. Print 2012 Jun. Citation on PubMed

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health.