Frequency
Farsightedness is a relatively common vision abnormality, although it is much less common than nearsightedness (myopia) or presbyopia. The prevalence of hyperopia decreases with age: most infants are farsighted at birth, but less than 4 percent of children have the condition at age 1. The prevalence continues to decrease into adulthood. Most cases are mild. For unknown reasons, farsightedness is reported more frequently among Native Americans, African Americans, and Pacific Islanders than in people of other backgrounds.
Causes
Farsightedness is a complex condition. Multiple genetic variations, each with a small effect, likely influence whether a person is farsighted. Few genes associated with the condition have been identified, and none of the identified genes appears to play a major role in the development of farsightedness. At least some of the genes that influence farsightedness play roles in eye development, particularly in determining the length of the eyeball from front to back (also known as the axial length). It is possible that environmental factors also contribute to a person's risk of being farsighted, but these have not been well-studied.
In many farsighted people, this vision problem is not part of a larger genetic syndrome. However, farsightedness (especially high hyperopia) can be a feature of other disorders with a genetic cause. Genetic conditions with farsightedness as a characteristic feature include microphthalmia, achromatopsia, aniridia, Leber congenital amaurosis, X-linked juvenile retinoschisis, Senior-Løken syndrome, Gorlin-Chaudhry-Moss syndrome, Down syndrome, and fragile X syndrome.
Inheritance
Farsightedness is a complex condition that usually does not have a clear pattern of inheritance. The risk of developing this condition is greater for first-degree relatives of affected individuals (such as siblings or children) as compared to the general public.
When farsightedness is a feature of a genetic syndrome, it follows the inheritance pattern of that syndrome.
Other Names for This Condition
- Far-sightedness
- Farsighted
- Hypermetropia
- Hyperopia
- Long-sighted
- Long-sightedness
Additional Information & Resources
Patient Support and Advocacy Resources
Clinical Trials
Catalog of Genes and Diseases from OMIM
Scientific Articles on PubMed
References
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- Jiang D, Yang Z, Li S, Xiao X, Jia X, Wang P, Guo X, Liu X, Zhang Q. Evaluation of PRSS56 in Chinese subjects with high hyperopia or primary angle-closure glaucoma. Mol Vis. 2013 Nov 7;19:2217-26. eCollection 2013. Citation on PubMed or Free article on PubMed Central
- Simpson CL, Wojciechowski R, Oexle K, Murgia F, Portas L, Li X, Verhoeven VJ, Vitart V, Schache M, Hosseini SM, Hysi PG, Raffel LJ, Cotch MF, Chew E, Klein BE, Klein R, Wong TY, van Duijn CM, Mitchell P, Saw SM, Fossarello M, Wang JJ; DCCT/EDIC Research Group; Polasek O, Campbell H, Rudan I, Oostra BA, Uitterlinden AG, Hofman A, Rivadeneira F, Amin N, Karssen LC, Vingerling JR, Doring A, Bettecken T, Bencic G, Gieger C, Wichmann HE, Wilson JF, Venturini C, Fleck B, Cumberland PM, Rahi JS, Hammond CJ, Hayward C, Wright AF, Paterson AD, Baird PN, Klaver CC, Rotter JI, Pirastu M, Meitinger T, Bailey-Wilson JE, Stambolian D. Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci. PLoS One. 2014 Sep 18;9(9):e107110. doi: 10.1371/journal.pone.0107110. eCollection 2014. Citation on PubMed or Free article on PubMed Central
- Xu Y, Guan L, Xiao X, Zhang J, Li S, Jiang H, Jia X, Yin Y, Guo X, Yang Z, Zhang Q. Identification of MFRP Mutations in Chinese Families with High Hyperopia. Optom Vis Sci. 2016 Jan;93(1):19-26. doi: 10.1097/OPX.0000000000000751. Citation on PubMed
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