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Taking medicines to treat tuberculosis

Tuberculosis (TB) is a contagious bacterial infection that involves the lungs, but may spread to other organs.

You may have a TB infection but no active disease or symptoms. This means the TB bacteria remain inactive (dormant) in a small area of your lungs. This type of infection may be present for years and is called latent TB. With latent TB:

  • You cannot spread TB to other people.
  • In some people, the bacteria can become active. If this happens, you may become sick, and you can pass the TB germs to someone else.
  • Even though you do not feel sick, you need to take medicines to treat latent TB for 6 to 9 months. This is the only way to make sure all of the TB bacteria in your body are killed.

When you have active TB, you may feel sick or have a cough, lose weight, feel tired, or have a fever or night sweats. With active TB:

  • You can pass TB to people around you. This includes people you live, work, or come in close contact with.
  • You need to take many medicines for TB for at least 6 months to rid your body of the TB bacteria. You should begin to feel better within a month of starting the medicines.
  • For the first 2 to 4 weeks after starting the medicines, you may need to stay home to avoid spreading TB to others. Ask your health care provider when it is OK to be around other people.
  • Your provider is required by law to report your TB to the local public health department.

Ask your provider if people you live or work with should be tested for TB.

How to Take the Medicines?

TB germs die very slowly. You need to take several different pills at different times of the day for 6 months or longer. The only way to get rid of the germs is to take your TB medicines the way your provider has instructed. This means taking all of your medicines every day.

If you do not take your TB medicines the right way, or stop taking the medicines early:

  • Your TB infection may become worse.
  • Your infection may become harder to treat. The drugs you are taking may no longer work. This is called drug-resistant TB.
  • You may need to take other medicines that cause more side effects and are less able to remove the infection.
  • You may spread the infection to others.

If your provider is worried that you may not be taking all the medicines as directed, they may arrange to have someone meet with you every day or a few times a week to watch you take your TB drugs. This is called directly observed therapy.

Side Effects and Other Problems

Women who may be pregnant, who are pregnant, or who are breastfeeding should talk to their provider before taking these medicines. If you are using birth control pills, ask your provider if your TB medicines can make birth control pills less effective.

Most people do not have very bad side effects from TB medicines. Problems to watch out for and tell your provider about include:

  • Achy joints
  • Bruising or easy bleeding
  • Fever
  • Poor appetite, or no appetite
  • Tingling or aches in your toes, fingers, or around your mouth
  • Upset stomach, nausea or vomiting, and stomach cramps or pain
  • Yellow skin or eyes
  • Urine is the color of tea or is orange (orange urine is normal with some of the medicines)

When to Call the Doctor

Call your provider if you have:

  • Any of the side effects listed above
  • New symptoms of active TB, such as cough, fever or night sweats, shortness of breath, or pain in the chest

Alternative Names

Tuberculosis - medicines; DOT; Directly observed therapy; TB - medicines


Ellner JJ. Tuberculosis. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 324.

Hopewell PC, Kato-Maeda M, Ernst JD. Tuberculosis. In: Broaddus VC, Mason RJ, Broaddus VC, Martin TR, et al, eds. Murray & Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 35.

Review Date 11/19/2015

Updated by: Denis Hadjiliadis, MD, MHS, Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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