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Midline venous catheters - infants

A midline venous catheter is a long (3 to 8 inches, or 7 to 20 centimeters) thin, soft plastic tube that is put into a small vein. This article addresses midline catheters in infants.



A midline venous catheter is used when an infant needs IV fluids or medicine over a long period of time. Regular IVs only last for 1 to 3 days and need to be replaced often. Midline catheters can stay in for 2 to 4 weeks.

Midline catheters are now often used in place of:

Because midline catheters do not reach beyond the armpit, they are considered safer. However, there may be some IV medicines that cannot be delivered through a midline catheter. Also, routine blood draws are not advised from a midline catheter, as opposed to the more central types of venous catheters.


A midline catheter is inserted into a vein in the arm, leg, or, occasionally, scalp of the infant.

The health care provider will:

  • Place the infant on the examination table
  • Receive help from other trained staff who will help calm and comfort the infant
  • Numb the area where the catheter will be placed
  • Clean the infant's skin with a germ-killing medicine (antiseptic)
  • Make a small surgical cut and place a hollow needle into a small vein in the arm, leg, or scalp
  • Place the midline catheter through the needle into a larger vein and remove the needle
  • Bandage the area where catheter has been placed


Risks of midline venous catheterization:

  • Infection. The risk is small, but increases the longer the midline catheter stays in place.
  • Bleeding and bruising at the site of insertion.
  • Inflammation of the vein (phlebitis).
  • Movement of the catheter out of place, even out of the vein.
  • Fluid leaking from the catheter into the tissues may lead to swelling and redness.
  • Breaking of the catheter inside the vein (very rare).

Alternative Names

Medial venous catheter - infants; MVC - infants; Midline catheter - infants; ML catheter - infants; ML - infants


Centers for Disease Control and Prevention. Summary of recommendations: guidelines for the prevention of intravascular catheter-related infections (2011). Updated October 2017. Accessed November 30, 2022.

Chenoweth KB, Guo J-W, Chan B. The extended dwell peripheral intravenous catheter is an alternative method of NICU intravenous access. Adv Neonatal Care. 2018;18(4):295-301. PMID: 29847401

Witt SH, Carr CM, Krywko DM. Indwelling vascular access devices: emergency access and management. In: Roberts JR, Custalow CB, Thomsen TW, eds. Roberts and Hedges' Clinical Procedures in Emergency Medicine and Acute Care. 7th ed. Philadelphia, PA: Elsevier; 2019:chap 24.

Review Date 7/19/2022

Updated by: Kimberly G. Lee, MD, MSc, IBCLC, Clinical Professor of Pediatrics, Division of Neonatology, Medical University of South Carolina, Charleston, SC. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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