All content below is taken in its entirety from the CDC Diphtheria, Tetanus, and Pertussis (DTaP) Vaccine Information Statement (VIS): www.cdc.gov/vaccines/hcp/vis/vis-statements/dtap.html
CDC review information for Diphtheria, Tetanus, and Pertussis (DTaP) VIS:
- Page last reviewed: June 13, 2014
- Page last updated: June 18, 2013
- Issue date of VIS: May 17, 2007
Content source: National Center for Immunization and Respiratory Diseases
Why get vaccinated?
Diphtheria, tetanus, and pertussis are serious diseases caused by bacteria. Diphtheria and pertussis are spread from person to person. Tetanus enters the body through cuts or wounds.
DIPHTHERIA causes a thick covering in the back of the throat.
It can lead to breathing problems, paralysis, heart failure, and even death.
TETANUS (Lockjaw) causes painful tightening of the muscles, usually all over the body.
It can lead to "locking" of the jaw so the victim cannot open his mouth or swallow. Tetanus leads to death in up to 2 out of 10 cases.
PERTUSSIS (Whooping Cough) causes coughing spells so bad that it is hard for infants to eat, drink, or breathe. These spells can last for weeks.
It can lead to pneumonia, seizures (jerking and staring spells), brain damage, and death.
Diphtheria, tetanus, and pertussis vaccine (DTaP) can help prevent these diseases. Most children who are vaccinated with DTaP will be protected throughout childhood. Many more children would get these diseases if we stopped vaccinating.
DTaP is a safer version of an older vaccine called DTP. DTP is no longer used in the United States.
Who should get DTaP vaccine and when?
Children should get 5 doses of DTaP vaccine, one dose at each of the following ages:
- 2 months
- 4 months
- 6 months
- 15 to 18 months
- 4 to 6 years
DTaP may be given at the same time as other vaccines.
Some children should not get DTaP vaccine or should wait.
- Children with minor illnesses, such as a cold, may be vaccinated. But children who are moderately or severely ill should usually wait until they recover before getting DTaP vaccine.
- Any child who had a life-threatening allergic reaction after a dose of DTaP should not get another dose.
- Any child who suffered a brain or nervous system disease within 7 days after a dose of DTaP should not get another dose.
- Talk with your doctor if your child:
- Had a seizure or collapsed after a dose of DTa
- Cried non-stop for 3 hours or more after a dose of DTaP
- Had a fever over 105°F (40.5°C) after a dose of DTaP
Ask your doctor for more information. Some of these children should not get another dose of pertussis vaccine, but may get a vaccine without pertussis, called DT.
Older children and adults
DTaP is not licensed for adolescents, adults, or children 7 years of age and older.
But older people still need protection. A vaccine called Tdap is similar to DTaP. A single dose of Tdap is recommended for people 11 through 64 years of age. Another vaccine, called Td, protects against tetanus and diphtheria, but not pertussis. It is recommended every 10 years. There are separate Vaccine Information Statements for these vaccines.
What are the risks from DTaP vaccine?
Getting diphtheria, tetanus, or pertussis disease is much riskier than getting DTaP vaccine.
However, a vaccine, like any medicine, is capable of causing serious problems, such as severe allergic reactions. The risk of DTaP vaccine causing serious harm, or death, is extremely small.
Mild problems (common)
- Fever (up to about 1 child in 4)
- Redness or swelling where the shot was given (up to about 1 child in 4)
- Soreness or tenderness where the shot was given (up to about 1 child in 4)
These problems occur more often after the 4th and 5th doses of the DTaP series than after earlier doses. Sometimes the 4th or 5th dose of DTaP vaccine is followed by swelling of the entire arm or leg in which the shot was given, lasting 1 to 7 days (up to about 1 child in 30).
Other mild problems include:
- Fussiness (up to about 1 child in 3)
- Tiredness or poor appetite (up to about 1 child in 10)
- Vomiting (up to about 1 child in 50)
These problems generally occur 1 to 3 days after the shot.
Moderate problems (uncommon)
- Seizure (jerking or staring) (about 1 child out of 14,000)
- Non-stop crying, for 3 hours or more (up to about 1 child out of 1,000)
- High fever, over 105°F (40.5°C) (about 1 child out of 16,000)
Severe problems (very rare)
- Serious allergic reaction (less than 1 out of a million doses)
- Several other severe problems have been reported after DTaP vaccine. These include:
- Long-term seizures, coma, or lowered consciousness
- Permanent brain damage
These are so rare it is hard to tell if they are caused by the vaccine.
Controlling fever is especially important for children who have had seizures, for any reason. It is also important if another family member has had seizures. You can reduce fever and pain by giving your child an aspirin-free pain reliever when the shot is given, and for the next 24 hours, following the package instructions.
What if there is a serious reaction?
What should I look for?
- Look for anything that concerns you, such as signs of a severe allergic reaction, very high fever, or behavior changes.
Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination.
What should I do?
- If you think it is a severe allergic reaction or other emergency that can't wait, call 9-1-1 or get the person to the nearest hospital. Otherwise, call your doctor.
- Afterward, the reaction should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your doctor might file this report, or you can do it yourself through the VAERS website or by calling 1-800-822-7967.
VAERS is only for reporting reactions. They do not give medical advice.
The National Vaccine Injury Compensation Program
The National Vaccine Injury Compensation Program (VICP) is a federal program that was created to compensate people who may have been injured by certain vaccines.
Persons who believe they may have been injured by a vaccine can learn about the program and about filing a claim by calling 1-800-338-2382 or visiting the VICP website.
How can I learn more?
- Ask your doctor.
- Contact your local or state health department -- www.cdc.gov/vaccines/imz-managers/awardee-imz-websites.html.
Contact the Centers for Disease Control and Prevention (CDC):
- Call 1-800-232-4636 (1-800-CDC-INFO)
- Visit CDC's vaccines website
Vaccine information statement: DTaP vaccine (Diphtheria, Tetanus, and Pertussis). Centers for Disease Control and Prevention Web site. www.cdc.gov/vaccines/hcp/vis/vis-statements/dtap.html. Accessed April 15, 2016.
Review Date 4/15/2016
Updated by: David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.