The creatinine clearance test helps provide information about how well the kidneys are working. The test compares the creatinine level in urine with the creatinine level in blood.
How to Prepare for the Test
Your health care provider may ask you to temporarily stop any medicines that may affect the test results. These include some antibiotics and stomach acid medicines. Be sure to tell your provider about all the medicines you take.
DO NOT stop taking any medicine before talking to your provider.
How the Test will Feel
The urine test involves only normal urination. There is no discomfort.
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
Creatinine is a chemical waste product of creatine. Creatine is a chemical the body makes to supply energy, mainly to muscles.
By comparing the creatinine level in urine with the creatinine level in blood, this test estimates the glomerular filtration rate (GFR). GFR is a measure of how well the kidneys are working, especially the kidneys' filtering units. These filtering units are called glomeruli.
Creatinine is removed, or cleared, from the body entirely by the kidneys. If kidney function is abnormal, creatinine level increases in the blood because less creatinine is released through the urine.
Clearance is often measured as milliliters per minute (mL/min) or milliliters per second (mL/s). Normal values are:
- Male: 97 to 137 mL/min (1.65 to 2.33 mL/s).
- Female: 88 to 128 mL/min (14.96 to 2.18 mL/s).
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor to