Cytochrome b5 reductase is an enzyme in the blood. It controls the amount of iron in your red blood cells, and helps the cells carry the normal amount of oxygen.
Persons who do not have enough of this enzyme may develop a condition called methemoglobinemia.
Bunn FH. Approach to the anemias. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 158.
DeBaun MR, Frei-Jones MJ, Vichinsky EP. Hemoglobinopathies. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 462.
Price EA, Otis S, Schier S. Red blood cell enzymopathies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Elsevier; 2013:chap 42.
Review Date 2/12/2016
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.