Hypophosphatemia is a low level of phosphorus in the blood.
The following may cause hypophosphatemia:
- Certain medicines, including insulin, acetazolamide, foscarnet, imatinib, intravenous iron, niacin, pentamidine, sorafenib, and tenofovir
- Fanconi syndrome
- Fat malabsorption in the gastrointestinal tract
- Hyperparathyroidism (overactive parathyroid gland)
- Too little vitamin D
Symptoms may include:
- Bone pain
- Muscle weakness
Exams and Tests
Your health care provider will examine you.
The following tests may be done:
- Kidney function tests
- Vitamin D blood test
Exam and testing may show:
- Anemia due to too many red blood cells being destroyed (hemolytic anemia)
- Heart muscle damage (cardiomyopathy)
Treatment depends on the cause. Phosphate can be given by mouth or through a vein (IV).
How well you do depends on what has caused the condition.
When to Contact a Medical Professional
Call your provider if you have muscle weakness or confusion.
Low blood phosphate; Phosphate - low; Hyperparathyroidism - low phosphate
Chonchol M, Smogorzewski MJ, Stubbs, JR, Yu ASL. Disorders of calcium, magnesium, and phosphate balance. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 18.
Klemm KM, Klein MJ, Zhang Y. Biochemical markers of bone metabolism. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 16.
Review Date 10/31/2021
Updated by: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.