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Gout is caused by increased production of uric acid. Uric acid crystals accumulate in the joints, especially in the feet and legs, causing great pain and swelling.

Review Date 4/24/2017

Updated by: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.