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Gout is caused by increased production of uric acid. Uric acid crystals travel and accumulate in the joints, especially in the feet and legs, causing great pain and swelling.

Review Date 4/28/2015

Updated by: Gordon A. Starkebaum, MD, Professor of Medicine, Division of Rheumatology, University of Washington School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.