In a person with Alzheimer disease, neurofibrillary tangles and plaques develop causing both structural and chemical problems in the brain. Alzheimer disease appears to disconnect areas of the brain that normally work together.
Review Date 1/19/2018
Updated by: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School of Rowan University/Cooper University Hospital, Camden, NJ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.