URL of this page: https://medlineplus.gov/druginfo/natural/875.html


What is it?

L-arginine is a chemical building block called "an amino acid." It is obtained from the diet and is necessary for the body to make proteins. L-arginine is found in red meat, poultry, fish, and dairy products. It can also be made in a laboratory and used as medicine.

L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain, high blood pressure, high cholesterol, heart surgery, recovery after heart transplant, heart attack, and coronary artery disease. L-arginine is also used for recurrent pain in the legs due to blocked arteries (intermittent claudication), decreased mental capacity in the elderly (senile dementia), erectile dysfunction (ED), altitude sickness, nitrate tolerance, diabetes, diabetic nerve pain, kidney toxicity from cyclosporine, kidney disease, tuberculosis, critical illness, head and neck cancer, obesity, ovary disease (polycystic ovary syndrome), pressure ulcers, respiratory infections, sickle cell disease, stress, and male infertility.

Some people use L-arginine for preventing the common cold, improving kidney function after a kidney transplant, high blood pressure during pregnancy (pre-eclampsia), improving athletic performance, boosting the immune system, and preventing inflammation and tissue death of the digestive tract in premature infants (necrotizing enterocolitis) and preventing slowing of growth of the baby within the uterus.

L-arginine is used in combination with a number of over-the-counter and prescription medications for various conditions. For example, L-arginine is used along with ibuprofen for migraine headaches; with conventional chemotherapy drugs for treating breast cancer; with other amino acids for treating weight loss in people with AIDS; and with fish oil and other supplements for reducing infections, improving wound healing, and shortening recovery time after surgery.

Some people apply L-arginine to the skin to speed wound healing, healing of small rips of the anus, and for increasing blood flow to cold hands and feet, especially in people with diabetes. It is also used as a cream for sexual problems in both men and women. Arginine has also been used for dental caries and dental hypersensitivity.

Finally, arginine has been injected into the vein for recurrent pain in the legs due to blocked arteries (intermittent claudication), reduced blood flow to the limbs (peripheral artery disease), for detecting growth hormone deficiency, disease due to defective mitochondria (mitochondrial encephalomyopathies), chest pain due to gastric problems, restenosis, kidney transplant, nutrition for the critically ill, metabolic acidosis, and increased blood pressure in the artery of the lungs (pulmonary hypertension) in newborns.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for L-ARGININE are as follows:

Possibly effective for...

  • Chest pain (angina). Taking L-arginine seems to decrease symptoms and improve exercise tolerance and quality of life in people with angina. However, L-arginine does not seem to help widen the blood vessels that are narrowed in angina.
  • Erectile dysfunction (ED). Taking 5 grams of L-arginine by mouth daily seems to improve sexual function in men with ED. Taking lower doses might not be effective. However, there is some early evidence that taking L-arginine with maritime pine bark extract and other ingredients, might improve the effectiveness of low-dose L-arginine for ED.
  • High blood pressure. There is early evidence that taking L-arginine by mouth can reduce blood pressure in healthy people, people with high blood pressure, and people with slightly high blood pressure with or without diabetes.
  • Inflammation and tissue death in the digestive tract in premature infants (necrotizing enterocolitis). Adding L-arginine to formula seems to prevent inflammation of the digestive tract in premature infants. A total of 5 premature infants need to receive arginine to prevent one instance of digestive tract inflammation.
  • Nitrate tolerance. Taking L-arginine by mouth seems to prevent nitrate tolerance in people taking nitroglycerin for chest pain (angina pectoris).
  • Leg pain associated with poor blood flow (peripheral arterial disease). Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. However, long-term use (up to 6 months) does not improve walking speed or distance in people with peripheral arterial disease.
  • Improving recovery after surgery. Taking L-arginine with ribonucleic acid (RNA) and eicosapentaenoic acid (EPA) before surgery or afterwards seems to help reduce the recovery time, reduce the number of infections, and improve wound healing after surgery.
  • High blood pressure during pregnancy (pre-eclampsia). Most research shows that L-arginine can reduce blood pressure in women with this condition. L-arginine might also prevent this condition in pregnant women.

Possibly ineffective for...

  • Kidney disease. Most early research suggests that taking L-arginine by mouth or intravenously (by IV) does not improve kidney function in most people with kidney failure or kidney disease. However, taking L-arginine by mouth might improve kidney function and reverse anemia in elderly people with kidney disease-associated anemia.
  • Heart attack. Taking L-arginine does not seem to help prevent a heart attack. It also does not seem to be beneficial for treating a heart attack after it has occurs. In fact, there is concern that L-arginine might be harmful for people after a recent heart attack. Do not take L-arginine if you have had a recent heart attack.
  • Tuberculosis. Adding arginine to standard treatment for tuberculosis does not seem to help improve symptoms or clear the infection.
  • Wound healing. Taking L-arginine does not seem to improve wound healing.

Insufficient evidence to rate effectiveness for...

  • AIDS-related wasting. Taking L-arginine by mouth, along with hydroxymethylbutyrate (HMB) and glutamine, for 8 weeks seems to increase body weight and improve immune function in people with HIV/AIDS. However, taking L-arginine by mouth, along with omega-3 fatty acids and a balanced nutritional supplement, for 6 months does not improve body weight or fat mass, energy intake, or immune function in people who are HIV-positive.
  • Altitude sickness. Early research suggests that L-arginine does not reduce altitude sickness.
  • Anal fissures. There is inconsistent evidence about that effects of L-arginine for treating anal fissures. Applying a topical gel containing L-arginine for at least 12 weeks might heal anal fissures in people who do not respond to traditional care. However, applying L-arginine to the skin does not seem to be better than surgery for anal fissures.
  • Breast cancer. Early research shows that taking L-arginine before chemotherapy does not improve the response rate in people with breast cancer.
  • Heart failure. Taking L-arginine by mouth, together with conventional treatment, seems to improve kidney function in people with heart failure. However, it might not improve the ability to exercise, quality of life, or blood circulation. L-arginine should not be used in place of conventional treatment.
  • Coronary artery bypass graft (CABG) surgery. There is mixed evidence about the effects of L-arginine in protecting the heart during CABG. Some research suggests that giving L-arginine intravenously (by IV) may be helpful in people undergoing CABG. Other research shows that it does not help.
  • Clogged blood vessels (coronary artery disease). Early research suggests that taking L-arginine intravenously (by IV) before exercising can improve blood vessel function in people with coronary artery disease. However, it does not improve blood flow to the heart.
  • Critical illness (trauma). Research shows that taking L-arginine by mouth with glutamine, nucleotides, and omega-3 fatty acids reduces the recovery time, the need for help with breathing, and risk of infections in people who are critically ill. However, it does not reduce the risk of death.
  • Memory loss (dementia). Early research suggests that L-arginine might improve memory loss related to aging.
  • Cavities. Early research suggests that using a sugarless mint containing an arginine complex (CaviStat) for one year reduces the number of cavities in molars of children compared with sugarless mints that do not contain arginine.
  • Sensitive teeth. Early research suggests that using a toothpaste containing arginine, calcium, and fluoride reduces tooth sensitivity when used twice daily.
  • Diabetes. Taking L-arginine by mouth seems to improve blood sugar control in people with existing diabetes. However, it is unclear if arginine helps prevent people with pre-diabetes from developing diabetes.
  • Diabetic foot ulcers. Early research shows that applying L-arginine to the feet daily can improve circulation in people with diabetes, which might be helpful in preventing diabetic foot ulcers. However, if there is already an ulcer on the foot, injecting L-arginine under the skin near the ulcer does not seem to shorten healing time or lower the chance of needing an amputation in the future.
  • Nerve damage due to diabetes. Early research suggests that taking L-arginine daily for 3 months does not improve nerve damage related to diabetes.
  • Muscle problems in the esophagus. Early research suggests that taking L-arginine by mouth or as an infusion can reduces the number and intensity of chest pain attacks in people with chest pain that is not related to the heart.
  • Exercise performance. There is inconsistent evidence about the effects of L-arginine on exercise performance. Some evidence shows that taking 6 grams of L-arginine in a drink increases exercise time until becoming tired. Also taking arginine with grape seed extract appears to improve working ability in men and decreases their tiredness. However, taking arginine 6 grams once does not affect strength during exercise.
  • Head and neck cancer. Supplementing a feeding tube with L-arginine does not seem to improve immune function, reduce tumor size, or improve healing in people with head and neck cancer.
  • Heart transplant. Early research suggests that taking L-arginine by mouth for 6 weeks increases walking distance and improves breathing in people with a heart transplant.
  • Infertility. There is inconsistent evidence about the effectiveness of L-arginine for infertility. Some early research suggests that taking 16 grams of L-arginine daily increases egg counts collected in women undergoing IVF. However, it does not seem to improve pregnancy rates. Other research suggests that taking L-arginine does not improve semen quality in men with unexplained infertility.
  • Bladder inflammation. Taking L-arginine by mouth seems to reduce pain and some symptoms of bladder inflammation, although improvements may take 3 months to occur. However, L-arginine does not seem to reduce the need to urinate at night or improve the frequency of urination.
  • Poor growth of fetus during pregnancy. Early research suggests that taking L-arginine during pregnancy can increase the birthweight of babies who show poor growth while still in their mother's womb. However, L-arginine does not seem to increase birthweight or reduce the risk of the baby dying if the baby has extremely poor growth while in the womb.
  • Mitochondrial encephalomyopathies (a group of disorders that lead to muscle and nervous system problems). There is some interest in using L-arginine to improve symptoms associated with MELAS (myoclonic epilepsy with lactic acidosis and stroke-like episodes) syndrome. Early research suggests that administering L-arginine intravenously (by IV) within one hour of stroke-like symptoms improves headaches, nausea, vomiting, blindness, and the appearance of bright spots in people with this condition.
  • Migraine headache. Taking L-arginine by mouth along with the painkiller ibuprofen seems to be effective for treating migraine headache. This combination sometimes starts to work within 30 minutes. However, it is hard to know how much of the pain relief is due to L-arginine, since ibuprofen can relieve migraine pain on its own.
  • Obesity. Early research suggests that taking a specific arginine supplement (NOW Foods, Bloomingdale, IL) 3 grams three times daily may decrease waist size and weight in women .
  • Ovarian disease (polycystic ovarian syndrome). Early research suggests that taking N-acetyl-cysteine and L-arginine daily for 6 months can improve menstrual function and reduces insulin resistance in people with polycystic ovarian syndrome.
  • Pressure ulcers. Taking L-arginine by mouth along with the painkiller ibuprofen seems to be effective for treating migraine headache. This combination sometimes starts to work within 30 minutes. However, it is hard to know how much of the pain relief is due to L-arginine, since ibuprofen can relieve migraine pain on its own.
  • Restricted blood flow (restenosis). Some research suggests that giving L-arginine during stent implantation followed by L-arginine supplementation by mouth for 2 weeks after stent implantation does not reduce the risk of restricted blood flow. However, other evidence suggests that administering L-arginine at the site of stent implantation may reduce artery wall thickening.
  • Kidney transplant. There is conflicting evidence about the effects of L-arginine for people with kidney transplants. It is unclear if it helps.
  • Respiratory infections. Early research suggests that taking L-arginine by mouth for 60 days prevents the recurrence of respiratory infections in children.
  • Sickle-cell disease. Early research suggests that taking L-arginine for 5 days might be useful for people with sickle cell disease who have high blood pressure in the lungs.
  • Stress. Some early research suggests that taking a combination of L-lysine and L-arginine for up to 10 days reduces stress and anxiety in healthy people and those prone to stress.
  • Prevention of the common cold.
  • Female sexual problems.
More evidence is needed to rate the effectiveness of L-arginine for these uses.

How does it work?

L-arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open wider for improved blood flow. L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body.

Are there safety concerns?

L-arginine is POSSIBLY SAFE for most people when taken appropriately by mouth, administered as a shot, or applied to the skin, short-term. It can cause some side effects such as abdominal pain, bloating, diarrhea, gout, blood abnormalities, allergies, airway inflammation, worsening of asthma, and low blood pressure.

Special precautions & warnings:

Pregnancy and breast-feeding: L-arginine is POSSIBLY SAFE when taken by mouth appropriately for a short-term during pregnancy. Not enough is known about using L-arginine long-term in pregnancy or during breast-feeding. Stay on the safe side and avoid use.

Children: L-arginine is POSSIBLY SAFE when used by mouth in premature infants in appropriate doses. However, L-arginine is POSSIBLY UNSAFE when used in high doses. Doses that are too high can cause serious side effects including death in children.

Allergies or asthma: L-arginine can cause an allergic response or make swelling in the airways worse. If you are prone to allergies or asthma and decide to take L-arginine, use it with caution.

Cirrhosis: L-arginine should be used with caution in people with cirrhosis.

Guanidinoacetate methyltransferase deficiency: People with this inherited condition are unable to convert arginine and other similar chemicals into creatine. To prevent complications associated with this condition, these people should not take arginine.

Herpes: There is a concern that L-arginine might make herpes worse. There is some evidence that L-arginine is needed for the herpes virus to multiply.

Low blood pressure: L-arginine might lower blood pressure. This could be a problem if you already have low blood pressure.

Recent heart attack: There is a concern that L-arginine might increase the risk of death after a heart attack, especially in older people. If you have had a heart attack recently, don't take L-arginine.

Kidney disease: L-arginine has caused high potassium levels when used by people with kidney disease. In some cases, this has resulted in a potentially life-threatening irregular heartbeat.

Surgery: L-arginine might affect blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop taking L-arginine at least 2 weeks before a scheduled surgery.

Are there interactions with medications?

Do not take this combination.
Medications for high blood pressure (Antihypertensive drugs)
L-arginine seems to decrease blood pressure. Taking L-arginine along with medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Be cautious with this combination.
Medications for diabetes (Antidiabetes drugs)
L-arginine seems to decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking L-arginine along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications for high blood pressure (ACE inhibitors)
L-arginine seems to decrease blood pressure. Taking L-arginine along with certain medications for high blood pressure, called ACE inhibitors might cause your blood pressure to go too low. Also, ACE inhibitors can increase potassium levels. L-arginine may also increase potassium levels. Taking L-arginine with ACE inhibitors might cause potassium levels to become too high.

Some ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik).
Medications for high blood pressure (Angiotensin receptor blockers (ARBs))
L-arginine seems to decrease blood pressure. Taking L-arginine along with medications for high blood pressure might cause your blood pressure to go too low.

The ARBs include losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), candesartan (Atacand), telmisartan (Micardis), and eprosartan (Teveten).
Medications for high blood pressure (Isoproterenol)
L-arginine seems to decrease blood pressure. Isoproterenol is a drug that is used to lower blood pressure. Taking L-arginine along with isoproterenol might cause your blood pressure to go too low.
Medications that increase blood flow to the heart (Nitrates)
L-arginine increases blood flow. Taking L-arginine with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness.

Some of these medications that increase blood flow to the heart include nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat), and isosorbide (Imdur, Isordil, Sorbitrate).
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
L-arginine seems to slow blood clotting. Taking L-arginine along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Sildenafil (Viagra)
Sildenafil (Viagra) can lower blood pressure. L-arginine can also lower blood pressure. Taking sildenafil (Viagra) and L-arginine together might cause the blood pressure to go too low. Blood pressure that is too low can cause dizziness and other side effects.
Water pills (Potassium-sparing diuretics)
L-arginine might increase potassium levels in the body. Some "water pills" might also increase potassium in the body. In theory, taking L-arginine along with some "water pills" might cause too much potassium to be in the body. Some water pills include amiloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium).

Some "water pills" that increase potassium in the body include spironolactone (Aldactone), triamterene (Dyrenium), and amiloride (Midamor).

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood pressure
L-arginine seems to lower blood pressure. Using it along with other herbs and supplements that have this same effect might increase the risk of blood pressure dropping too low in some people. Some of these products include andrographis, casein peptides, cat's claw, coenzyme Q-10, fish oil, L-arginine, lycium, stinging nettle, theanine, and others.
Herbs and supplements that might lower blood sugar
L-arginine seems to lower blood sugar. Using it along with other herbs and supplements that have the same effect might cause blood sugar to become too low in some people. Some of these products include devil's claw, fenugreek, guar gum, Panax ginseng, Siberian ginseng, and others.
Herbs and supplements that might slow blood clotting
Using L-arginine along with herbs that can slow blood clotting could increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginkgo, Panax ginseng, red clover, turmeric, and others.
L-arginine can cause an organ in the body called the pancreas to release a hormone called glucagon. Glucagon comes to the rescue when blood sugar levels are too low. Glucagon makes the liver convert stored sugar to useable sugar that is released into the bloodstream. Using L-arginine along with xylitol can keep L-arginine from stimulating the pancreas to release glucagon.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

  • For chest pain associated with coronary artery disease (angina pectoris): 3-6 grams three times per day for up to one month.
  • For preventing the loss of the effectiveness of nitroglycerin in relieving pain in people with chest pain due to coronary artery disease (angina pectoris): 700 mg four times daily.
  • For organic erectile dysfunction (ED): 5 grams per day. Taking lower doses might not be effective.
  • For high blood pressure: 4-24 grams per day for 2-24 weeks.
  • For preventing inflammation of the digestive tract in premature infants: 261 mg/kg added to oral feedings daily for the first 28 days of life.
  • For reducing pain when walking in people with a disease called peripheral arterial disease: 6 grams for up to 8 weeks.
  • For preventing high blood pressure during pregnancy: 3 grams daily for 3 weeks. Two bars of a medical food (Heart Bars) with arginine 6.6 grams and antioxidant vitamins daily starting at 14-32 weeks gestation and continuing until delivery. 4 grams arginine (Bioarginina, Damor, Italy) daily for 10-12 weeks.
  • For reducing pain when walking in people with a disease called peripheral arterial disease: 6 grams for up to 8 weeks.

Other names

2-Amino-5-(diaminomethylidene amino) pentanoic acid, 2-Amino-5-guanidinopentanoic Acid, (2S)-2-Amino-5-{[amino (imino) methyl]amino}pentanoic Acid, (S)-2-Amino-5- Guanidinopentanoic Acid, Acide 2-Amino-5-Guanidinopentanoïque, Arg, Arginine, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine HCl, Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginina, L-Arginine Ethyl Ester Dichloride, L-Arginine HCl, L-Arginine Hexanoate, L-Arginine Hydrochloride, L-Arginine Ketoisocaproic Acid, L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R-Gene 10.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


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  156. Boger, R. H., Sullivan, L. M., Schwedhelm, E., Wang, T. J., Maas, R., Benjamin, E. J., Schulze, F., Xanthakis, V., Benndorf, R. A., and Vasan, R. S. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 3-31-2009;119:1592-1600. View abstract.
  157. Little, J. A., Hauser, K. P., Martyr, S. E., Harris, A., Maric, I., Morris, C. R., Suh, J. H., Taylor, J., Castro, O., Machado, R., Kato, G., and Gladwin, M. T. Hematologic, biochemical, and cardiopulmonary effects of L-arginine supplementation or phosphodiesterase 5 inhibition in patients with sickle cell disease who are on hydroxyurea therapy. Eur.J Haematol. 2009;82:315-321. View abstract.
  158. Takasaki, A., Tamura, H., Miwa, I., Taketani, T., Shimamura, K., and Sugino, N. Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium. Fertil.Steril. 2010;93:1851-1858. View abstract.
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  162. Stanislavov, R., Nikolova, V., and Rohdewald, P. Improvement of seminal parameters with Prelox: a randomized, double-blind, placebo-controlled, cross-over trial. Phytother.Res 2009;23:297-302. View abstract.
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  166. Gad, M. Z., El-Mesallamy, H. O., and Sanad, E. F. hsCRP, sICAM-1 and TAFI in hemodialysis patients: linking inflammation and hypofibrinolysis to cardiovascular events. Kidney Blood Press Res 2008;31:391-397. View abstract.
  167. Napoli, C., Farzati, B., Sica, V., Iannuzzi, E., Coppola, G., Silvestroni, A., Balestrieri, M. L., Florio, A., and Matarazzo, A. Beneficial effects of autologous bone marrow cell infusion and antioxidants/L-arginine in patients with chronic critical limb ischemia. Eur.J Cardiovasc.Prev.Rehabil. 2008;15:709-718. View abstract.
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  170. Fons, C., Sempere, A., Arias, A., Lopez-Sala, A., Poo, P., Pineda, M., Mas, A., Vilaseca, M. A., Salomons, G. S., Ribes, A., Artuch, R., and Campistol, J. Arginine supplementation in four patients with X-linked creatine transporter defect. J Inherit.Metab Dis 2008;31:724-728. View abstract.
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  172. Settergren, M., Bohm, F., Malmstrom, R. E., Channon, K. M., and Pernow, J. L-arginine and tetrahydrobiopterin protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis 2009;204:73-78. View abstract.
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  175. Klek, S., Kulig, J., Sierzega, M., Szybinski, P., Szczepanek, K., Kubisz, A., Kowalczyk, T., Gach, T., Pach, R., and Szczepanik, A. M. The impact of immunostimulating nutrition on infectious complications after upper gastrointestinal surgery: a prospective, randomized, clinical trial. Ann.Surg. 2008;248:212-220. View abstract.
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  178. Chilosi, A., Leuzzi, V., Battini, R., Tosetti, M., Ferretti, G., Comparini, A., Casarano, M., Moretti, E., Alessandri, M. G., Bianchi, M. C., and Cioni, G. Treatment with L-arginine improves neuropsychological disorders in a child with creatine transporter defect. Neurocase. 2008;14:151-161. View abstract.
  179. Tuchman, M., Lee, B., Lichter-Konecki, U., Summar, M. L., Yudkoff, M., Cederbaum, S. D., Kerr, D. S., Diaz, G. A., Seashore, M. R., Lee, H. S., McCarter, R. J., Krischer, J. P., and Batshaw, M. L. Cross-sectional multicenter study of patients with urea cycle disorders in the United States. Mol.Genet.Metab 2008;94:397-402. View abstract.
  180. Chung, H. T., Choi, B. M., Kwon, Y. G., and Kim, Y. M. Interactive relations between nitric oxide (NO) and carbon monoxide (CO): heme oxygenase-1/CO pathway is a key modulator in NO-mediated antiapoptosis and anti-inflammation. Methods Enzymol. 2008;441:329-338. View abstract.
  181. Yeo, T. W., Lampah, D. A., Gitawati, R., Tjitra, E., Kenangalem, E., Granger, D. L., Weinberg, J. B., Lopansri, B. K., Price, R. N., Celermajer, D. S., Duffull, S. B., and Anstey, N. M. Safety profile of L-arginine infusion in moderately severe falciparum malaria. PLoS.One. 2008;3:e2347. View abstract.
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  183. Acevedo, A. M., Montero, M., Rojas-Sanchez, F., Machado, C., Rivera, L. E., Wolff, M., and Kleinberg, I. Clinical evaluation of the ability of CaviStat in a mint confection to inhibit the development of dental caries in children. J Clin.Dent. 2008;19:1-8. View abstract.
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  187. Mhanni, A. A., Chan, A., Collison, M., Seifert, B., Lehotay, D. C., Sokoro, A., Huynh, H. Q., and Greenberg, C. R. Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHH) presenting with acute fulminant hepatic failure. J Pediatr Gastroenterol.Nutr. 2008;46:312-315. View abstract.
  188. Ruel, M., Beanlands, R. S., Lortie, M., Chan, V., Camack, N., deKemp, R. A., Suuronen, E. J., Rubens, F. D., DaSilva, J. N., Sellke, F. W., Stewart, D. J., and Mesana, T. G. Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial. J Thorac.Cardiovasc.Surg. 2008;135:762-70, 770. View abstract.
  189. Hackett, A., Gillard, J., and Wilcken, B. n of 1 trial for an ornithine transcarbamylase deficiency carrier. Mol.Genet.Metab 2008;94:157-161. View abstract.
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  198. Siasos, G., Tousoulis, D., Vlachopoulos, C., Antoniades, C., Stefanadi, E., Ioakeimidis, N., Andreou, I., Zisimos, K., Papavassiliou, A. G., and Stefanadis, C. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. Int.J Cardiol 6-6-2008;126:394-399. View abstract.
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  231. Gosselink, M. P., Darby, M., Zimmerman, D. D., Gruss, H. J., and Schouten, W. R. Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients. Dis Colon Rectum 2005;48:832-837. View abstract.
  232. Baecker, N., Boese, A., Schoenau, E., Gerzer, R., and Heer, M. L-arginine, the natural precursor of NO, is not effective for preventing bone loss in postmenopausal women. J Bone Miner.Res 2005;20:471-479. View abstract.
  233. Koga, Y., Akita, Y., Nishioka, J., Yatsuga, S., Povalko, N., Tanabe, Y., Fujimoto, S., and Matsuishi, T. L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology 2-22-2005;64:710-712. View abstract.
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  237. Grasemann, H., Grasemann, C., Kurtz, F., Tietze-Schillings, G., Vester, U., and Ratjen, F. Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study. Eur.Respir.J 2005;25:62-68. View abstract.
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  239. Xiao, X. M. and Li, L. P. L-Arginine treatment for asymmetric fetal growth restriction. Int.J Gynaecol.Obstet. 2005;88:15-18. View abstract.
  240. Kernohan, A. F., McIntyre, M., Hughes, D. M., Tam, S. W., Worcel, M., and Reid, J. L. An oral yohimbine/L-arginine combination (NMI 861) for the treatment of male erectile dysfunction: a pharmacokinetic, pharmacodynamic and interaction study with intravenous nitroglycerine in healthy male subjects. Br J Clin.Pharmacol. 2005;59:85-93. View abstract.
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  243. Kiziltepe, U., Tunctan, B., Eyileten, Z. B., Sirlak, M., Arikbuku, M., Tasoz, R., Uysalel, A., and Ozyurda, U. Efficiency of L-arginine enriched cardioplegia and non-cardioplegic reperfusion in ischemic hearts. Int.J Cardiol 2004;97:93-100. View abstract.
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  247. George, J., Shmuel, S. B., Roth, A., Herz, I., Izraelov, S., Deutsch, V., Keren, G., and Miller, H. L-arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in patients undergoing angioplasty. Atherosclerosis 2004;174:323-327. View abstract.
  248. Dudek, D., Legutko, J., Heba, G., Bartus, S., Partyka, L., Huk, I., Dembinska-Kiec, A., Kaluza, G. L., and Dubiel, J. S. L-arginine supplementation does not inhibit neointimal formation after coronary stenting in human beings: an intravascular ultrasound study. Am Heart J 2004;147:E12. View abstract.
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  251. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82:413-417. View abstract.
  252. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724. View abstract.
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  254. Houwing, R. H., Rozendaal, M., Wouters-Wesseling, W., Beulens, J. W., Buskens, E., and Haalboom, J. R. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin.Nutr. 2003;22:401-405. View abstract.
  255. McGovern, M. M., Wasserstein, M. P., Aron, A., and Perrine, S. P. Biochemical effect of intravenous arginine butyrate in X-linked adrenoleukodystrophy. J Pediatr 2003;142:709-713. View abstract.
  256. Dallinger, S., Sieder, A., Strametz, J., Bayerle-Eder, M., Wolzt, M., and Schmetterer, L. Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans. Am J Physiol Endocrinol.Metab 2003;284:E1106-E1111. View abstract.
  257. Abdelhamed, A. I., Reis, S. E., Sane, D. C., Brosnihan, K. B., Preli, R. B., and Herrington, D. M. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J 2003;145:E15. View abstract.
  258. Sydow, K., Schwedhelm, E., Arakawa, N., Bode-Boger, S. M., Tsikas, D., Hornig, B., Frolich, J. C., and Boger, R. H. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovasc.Res 2003;57:244-252. View abstract.
  259. Miller, H. I., Dascalu, A., Rassin, T. A., Wollman, Y., Chernichowsky, T., and Iaina, A. Effects of an acute dose of L-arginine during coronary angiography in patients with chronic renal failure: a randomized, parallel, double-blind clinical trial. Am J Nephrol. 2003;23:91-95. View abstract.
  260. Braga, M., Gianotti, L., Vignali, A., and Carlo, V. D. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery 2002;132:805-814. View abstract.
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  263. Lekakis, J. P., Papathanassiou, S., Papaioannou, T. G., Papamichael, C. M., Zakopoulos, N., Kotsis, V., Dagre, A. G., Stamatelopoulos, K., Protogerou, A., and Stamatelopoulos, S. F. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int.J Cardiol 2002;86(2-3):317-323. View abstract.
  264. Song, J. X., Qing, S. H., Huang, X. C., and Qi, D. L. Effect of parenteral nutrition with L-arginine supplementation on postoperative immune function in patients with colorectal cancer. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22:545-547. View abstract.
  265. Bennett-Richards, K. J., Kattenhorn, M., Donald, A. E., Oakley, G. R., Varghese, Z., Bruckdorfer, K. R., Deanfield, J. E., and Rees, L. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int. 2002;62:1372-1378. View abstract.
  266. Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., and Lonsdorfer, J. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int.J Sports Med. 2002;23:403-407. View abstract.
  267. Cassone, Faldetta M., Laurenti, O., Desideri, G., Bravi, M. C., De, Luca O., Marinucci, M. C., De, Mattia G., and Ferri, C. L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Diabetologia 2002;45:1120-1127. View abstract.
  268. van den Meiracker, A. H., van der Linde, N. A., Broere, A., Derkx, F. H., and Boomsma, F. Effects of L-arginine and L-NAME on the renal function in hypertensive and normotensive subjects. Nephron 2002;91:444-451. View abstract.
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  272. Schramm, L., La, M., Heidbreder, E., Hecker, M., Beckman, J. S., Lopau, K., Zimmermann, J., Rendl, J., Reiners, C., Winderl, S., Wanner, C., and Schmidt, H. H. L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int. 2002;61:1423-1432. View abstract.
  273. Carrier, M., Pellerin, M., Perrault, L. P., Bouchard, D., Page, P., Searle, N., and Lavoie, J. Cardioplegic arrest with L-arginine improves myocardial protection: results of a prospective randomized clinical trial. Ann.Thorac.Surg. 2002;73:837-841. View abstract.
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  275. Suzuki, T., Hayase, M., Hibi, K., Hosokawa, H., Yokoya, K., Fitzgerald, P. J., Yock, P. G., Cooke, J. P., Suzuki, T., and Yeung, A. C. Effect of local delivery of L-arginine on in-stent restenosis in humans. Am J Cardiol 2-15-2002;89:363-367. View abstract.
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  277. Bello, E., Caramelo, C., Martell, N., Alcazar, J. M., Gonzalez, J., Lopez, M. D., Ruilope, L. M., Gonzalez, F. R., Rovira, A. M., Gazapo, R., Soldevilla, M. J., and Casado, S. Impairment of renal vasodilation with l-arginine is related to more severe disease in untreated hypertensive patients. Hypertension 2001;38:907-912. View abstract.
  278. Mantovani, F., Patelli, E., Colombo, F., Pozzoni, F., Confalonieri, S., and Pisani, E. [Erectile dysfunction after non-nerve sparing radical pelvic surgery. Therapeutical experience with sildenafil and L-arginine evaluated by Buckling test]. Minerva Med. 2001;92:285-287. View abstract.
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  280. Piatti, P. M., Monti, L. D., Valsecchi, G., Magni, F., Setola, E., Marchesi, F., Galli-Kienle, M., Pozza, G., and Alberti, K. G. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 2001;24:875-880. View abstract.
  281. Angdin, M., Settergren, G., Liska, J., and Astudillo, R. No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass. Acta Anaesthesiol.Scand. 2001;45:441-448. View abstract.
  282. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir.Crit Care Med. 2001;163:887-891. View abstract.
  283. van Bokhorst-De Van Der Schueren, MA, Quak, J. J., von Blomberg-van der Flier BM, Kuik, D. J., Langendoen, S. I., Snow, G. B., Green, C. J., and van Leeuwen, P. A. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am.J Clin.Nutr 2001;73:323-332. View abstract.
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Last reviewed - 08/08/2017